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Modulation of leptin levels by oxidized linoleic acid: a connection to atherosclerosis?
J Med Food. 2011 Apr; 14(4):441-3.JM

Abstract

The objective of the study was to determine the effects of oxidized linoleic acid (Ox-LA) on plasma leptin and to determine the relationship between plasma leptin levels and atherosclerosis in animals treated with Ox-LA. Low-density lipoprotein (LDL) receptor knockout (LDL r(-/-)) mice were fed a high fat diet with or without Ox-LA for 11 weeks. Plasma leptin levels in the high fat group consuming Ox-LA were significantly higher (14,052 ± 601 pg/mL vs. 10,950 ± 541 pg/mL; P < .01) compared to the group receiving the high fat diet alone. There was a highly significant correlation between the plasma leptin levels and aortic atherosclerotic lesions. From this we conclude that chronic exposure to dietary Ox-LA increases the plasma levels of leptin in LDL r(-/-) mice on a high fat diet. Considering our previous finding that dietary Ox-LA increased atherosclerosis, the current findings emphasize the need to reduce dietary intake of oxidized fat.

Authors+Show Affiliations

Division of Nutrition, School of Health Professions, Georgia State University, Atlanta, Georgia, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21186986

Citation

Penumetcha, Meera, et al. "Modulation of Leptin Levels By Oxidized Linoleic Acid: a Connection to Atherosclerosis?" Journal of Medicinal Food, vol. 14, no. 4, 2011, pp. 441-3.
Penumetcha M, Merchant N, Parthasarathy S. Modulation of leptin levels by oxidized linoleic acid: a connection to atherosclerosis? J Med Food. 2011;14(4):441-3.
Penumetcha, M., Merchant, N., & Parthasarathy, S. (2011). Modulation of leptin levels by oxidized linoleic acid: a connection to atherosclerosis? Journal of Medicinal Food, 14(4), 441-3. https://doi.org/10.1089/jmf.2010.0059
Penumetcha M, Merchant N, Parthasarathy S. Modulation of Leptin Levels By Oxidized Linoleic Acid: a Connection to Atherosclerosis. J Med Food. 2011;14(4):441-3. PubMed PMID: 21186986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of leptin levels by oxidized linoleic acid: a connection to atherosclerosis? AU - Penumetcha,Meera, AU - Merchant,Nadya, AU - Parthasarathy,Sampath, Y1 - 2010/12/27/ PY - 2010/12/29/entrez PY - 2010/12/29/pubmed PY - 2011/7/13/medline SP - 441 EP - 3 JF - Journal of medicinal food JO - J Med Food VL - 14 IS - 4 N2 - The objective of the study was to determine the effects of oxidized linoleic acid (Ox-LA) on plasma leptin and to determine the relationship between plasma leptin levels and atherosclerosis in animals treated with Ox-LA. Low-density lipoprotein (LDL) receptor knockout (LDL r(-/-)) mice were fed a high fat diet with or without Ox-LA for 11 weeks. Plasma leptin levels in the high fat group consuming Ox-LA were significantly higher (14,052 ± 601 pg/mL vs. 10,950 ± 541 pg/mL; P < .01) compared to the group receiving the high fat diet alone. There was a highly significant correlation between the plasma leptin levels and aortic atherosclerotic lesions. From this we conclude that chronic exposure to dietary Ox-LA increases the plasma levels of leptin in LDL r(-/-) mice on a high fat diet. Considering our previous finding that dietary Ox-LA increased atherosclerosis, the current findings emphasize the need to reduce dietary intake of oxidized fat. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/21186986/Modulation_of_leptin_levels_by_oxidized_linoleic_acid:_a_connection_to_atherosclerosis L2 - https://www.liebertpub.com/doi/10.1089/jmf.2010.0059?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -