Citation
Bucossi, Serena, et al. "Copper in Alzheimer's Disease: a Meta-analysis of Serum,plasma, and Cerebrospinal Fluid Studies." Journal of Alzheimer's Disease : JAD, vol. 24, no. 1, 2011, pp. 175-85.
Bucossi S, Ventriglia M, Panetta V, et al. Copper in Alzheimer's disease: a meta-analysis of serum,plasma, and cerebrospinal fluid studies. J Alzheimers Dis. 2011;24(1):175-85.
Bucossi, S., Ventriglia, M., Panetta, V., Salustri, C., Pasqualetti, P., Mariani, S., Siotto, M., Rossini, P. M., & Squitti, R. (2011). Copper in Alzheimer's disease: a meta-analysis of serum,plasma, and cerebrospinal fluid studies. Journal of Alzheimer's Disease : JAD, 24(1), 175-85. https://doi.org/10.3233/JAD-2010-101473
Bucossi S, et al. Copper in Alzheimer's Disease: a Meta-analysis of Serum,plasma, and Cerebrospinal Fluid Studies. J Alzheimers Dis. 2011;24(1):175-85. PubMed PMID: 21187586.
TY - JOUR
T1 - Copper in Alzheimer's disease: a meta-analysis of serum,plasma, and cerebrospinal fluid studies.
AU - Bucossi,Serena,
AU - Ventriglia,Mariacarla,
AU - Panetta,Valentina,
AU - Salustri,Carlo,
AU - Pasqualetti,Patrizio,
AU - Mariani,Stefania,
AU - Siotto,Mariacristina,
AU - Rossini,Paolo Maria,
AU - Squitti,Rosanna,
PY - 2010/12/29/entrez
PY - 2010/12/29/pubmed
PY - 2012/3/7/medline
SP - 175
EP - 85
JF - Journal of Alzheimer's disease : JAD
JO - J Alzheimers Dis
VL - 24
IS - 1
N2 - There is an ongoing debate on the involvement of systemic copper (Cu) dysfunctions in Alzheimer's disease (AD), and clinical studies comparing Cu levels in serum, plasma, and cerebrospinal fluid (CSF) of AD patients with those of healthy controls have delivered non-univocal and often conflicting results. In an attempt to evaluate whether Cu should be considered a potential marker of AD, we applied meta-analysis to a selection of 26 studies published in the literature. Meta-analysis is a quantitative method that combines the results of independent reports to distinguish between small effects and no effects, random variations, variations in sample used, or in different analytical approaches. The subjects' sample obtained by merging studies was a pooled total of 761 AD subjects and 664 controls for serum Cu studies, 205 AD subjects and 167 controls for plasma Cu, and of 116 AD subjects and 129 controls for CSF Cu. Our meta-analysis of serum data showed that AD patients have higher levels of serum Cu than healthy controls. Plasma data did not allow conclusions, due to their high heterogeneity, but the meta-analysis of the combined serum and plasma studies confirmed higher Cu levels in AD. The analysis of CSF data, instead, revealed no difference between AD patients and controls.
SN - 1875-8908
UR - https://www.unboundmedicine.com/medline/citation/21187586/Copper_in_Alzheimer's_disease:_a_meta_analysis_of_serumplasma_and_cerebrospinal_fluid_studies_
L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2010-101473
DB - PRIME
DP - Unbound Medicine
ER -