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25-hydroxyvitamin D deficiency in kidney transplant recipients.
Iran J Kidney Dis. 2011 Jan; 5(1):57-62.IJ

Abstract

INTRODUCTION.

After kidney transplantation, patients appear to have vitamin D deficiency due to the use of immunosuppressive treatment and prevention of sunlight. This study was designed to determine vitamin D serum levels in kidney transplant patients in comparison with healthy individuals. MATERIALS AND

METHODS.

Forty-six kidney transplant patients with a creatinine clearance greater than 60 mL/min and 46 healthy individuals with normal kidney function were tested for serum levels of calcium, phosphorus, 25-hydroxyvitamin D, and parathyroid hormone at the end of the summer.

RESULTS.

Thirty-one participants were men and 15 were women in each group. The mean age was 41.0 ± 14.2 years in kidney transplant recipients and 41.4 ± 13.7 years in the control group. Inadequate serum 25-hydroxyvitamin D was seen in 93.5% of the transplant patients and in 89.1% of the controls. There was a 26.1% [corrected] vitamin D insufficiency (20 ng/mL to 30 ng/mL) and a 67.4% [corrected] deficiency (lower than 20 ng/mL) in the patients, and these rates were 21.7% [corrected] and 67.4% [corrected] in the control group, respectively. There was no significant difference between the two groups.

CONCLUSIONS.

Vitamin D deficiency is prevalent in kidney transplant patients. Lack of a significant difference between our two groups may be attributable to the high prevalence of vitamin D deficiency in general population and the use of vitamin D supplementation in transplant patients. Indeed, adequate doses of vitamin D in these patients are undetermined. They may need higher doses for normalization of serum vitamin D and metabolic requirements.

Authors+Show Affiliations

Department of Nephrology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21189437

Citation

Taziki, Omolbanin, et al. "25-hydroxyvitamin D Deficiency in Kidney Transplant Recipients." Iranian Journal of Kidney Diseases, vol. 5, no. 1, 2011, pp. 57-62.
Taziki O, Espahbodi F, Alizadeh Forutan M, et al. 25-hydroxyvitamin D deficiency in kidney transplant recipients. Iran J Kidney Dis. 2011;5(1):57-62.
Taziki, O., Espahbodi, F., Alizadeh Forutan, M., & Kashi, Z. (2011). 25-hydroxyvitamin D deficiency in kidney transplant recipients. Iranian Journal of Kidney Diseases, 5(1), 57-62.
Taziki O, et al. 25-hydroxyvitamin D Deficiency in Kidney Transplant Recipients. Iran J Kidney Dis. 2011;5(1):57-62. PubMed PMID: 21189437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 25-hydroxyvitamin D deficiency in kidney transplant recipients. AU - Taziki,Omolbanin, AU - Espahbodi,Fatemeh, AU - Alizadeh Forutan,Maryam, AU - Kashi,Zahra, PY - 2010/04/07/received PY - 2010/09/21/accepted PY - 2010/12/30/entrez PY - 2010/12/30/pubmed PY - 2011/6/29/medline SP - 57 EP - 62 JF - Iranian journal of kidney diseases JO - Iran J Kidney Dis VL - 5 IS - 1 N2 - INTRODUCTION. After kidney transplantation, patients appear to have vitamin D deficiency due to the use of immunosuppressive treatment and prevention of sunlight. This study was designed to determine vitamin D serum levels in kidney transplant patients in comparison with healthy individuals. MATERIALS AND METHODS. Forty-six kidney transplant patients with a creatinine clearance greater than 60 mL/min and 46 healthy individuals with normal kidney function were tested for serum levels of calcium, phosphorus, 25-hydroxyvitamin D, and parathyroid hormone at the end of the summer. RESULTS. Thirty-one participants were men and 15 were women in each group. The mean age was 41.0 ± 14.2 years in kidney transplant recipients and 41.4 ± 13.7 years in the control group. Inadequate serum 25-hydroxyvitamin D was seen in 93.5% of the transplant patients and in 89.1% of the controls. There was a 26.1% [corrected] vitamin D insufficiency (20 ng/mL to 30 ng/mL) and a 67.4% [corrected] deficiency (lower than 20 ng/mL) in the patients, and these rates were 21.7% [corrected] and 67.4% [corrected] in the control group, respectively. There was no significant difference between the two groups. CONCLUSIONS. Vitamin D deficiency is prevalent in kidney transplant patients. Lack of a significant difference between our two groups may be attributable to the high prevalence of vitamin D deficiency in general population and the use of vitamin D supplementation in transplant patients. Indeed, adequate doses of vitamin D in these patients are undetermined. They may need higher doses for normalization of serum vitamin D and metabolic requirements. SN - 1735-8582 UR - https://www.unboundmedicine.com/medline/citation/21189437/25_hydroxyvitamin_D_deficiency_in_kidney_transplant_recipients_ L2 - http://www.ijkd.org/index.php/ijkd/article/view/353/256 DB - PRIME DP - Unbound Medicine ER -