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Does B12 deficiency lead to lack of treatment response to conventional antidepressants?

Abstract

We present two cases of treatment-resistant depression that improved with recognition and correction of the underlying medical etiology of vitamin B12 deficiency. Supplementations of vitamin B12 to the same antidepressant regimen that the patient had not responded earlier led to response. Two male subjects who were vegetarians presented with long-standing histories of depression and had not responded to three adequate trials of antidepressants. Upon investigation, the authors found that the subjects had low vitamin B12 levels. Both cases improved with supplementation of vitamin B12. Subjects with depression who do not respond to conventional antidepressants should be evaluated for nutritional factors.

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  • Authors+Show Affiliations

    ,

    Ms. Kate is Junior Resident is from the Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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    Source

    Pub Type(s)

    Case Reports

    Language

    eng

    PubMed ID

    21191533

    Citation

    Kate, Natasha, et al. "Does B12 Deficiency Lead to Lack of Treatment Response to Conventional Antidepressants?" Psychiatry (Edgmont (Pa. : Township)), vol. 7, no. 11, 2010, pp. 42-4.
    Kate N, Grover S, Agarwal M. Does B12 deficiency lead to lack of treatment response to conventional antidepressants? Psychiatry (Edgmont). 2010;7(11):42-4.
    Kate, N., Grover, S., & Agarwal, M. (2010). Does B12 deficiency lead to lack of treatment response to conventional antidepressants? Psychiatry (Edgmont (Pa. : Township)), 7(11), pp. 42-4.
    Kate N, Grover S, Agarwal M. Does B12 Deficiency Lead to Lack of Treatment Response to Conventional Antidepressants. Psychiatry (Edgmont). 2010;7(11):42-4. PubMed PMID: 21191533.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Does B12 deficiency lead to lack of treatment response to conventional antidepressants? AU - Kate,Natasha, AU - Grover,Sandeep, AU - Agarwal,Munish, PY - 2010/12/31/entrez PY - 2010/12/31/pubmed PY - 2010/12/31/medline KW - Depression KW - Vitamin B12 deficiency KW - treatment resistance SP - 42 EP - 4 JF - Psychiatry (Edgmont (Pa. : Township)) JO - Psychiatry (Edgmont) VL - 7 IS - 11 N2 - We present two cases of treatment-resistant depression that improved with recognition and correction of the underlying medical etiology of vitamin B12 deficiency. Supplementations of vitamin B12 to the same antidepressant regimen that the patient had not responded earlier led to response. Two male subjects who were vegetarians presented with long-standing histories of depression and had not responded to three adequate trials of antidepressants. Upon investigation, the authors found that the subjects had low vitamin B12 levels. Both cases improved with supplementation of vitamin B12. Subjects with depression who do not respond to conventional antidepressants should be evaluated for nutritional factors. SN - 1555-5194 UR - https://www.unboundmedicine.com/medline/citation/21191533/Does_B12_deficiency_lead_to_lack_of_treatment_response_to_conventional_antidepressants L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21191533/ DB - PRIME DP - Unbound Medicine ER -