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Natural history of HIV infection in former plasma donors in rural China.
Front Med China. 2010 Sep; 4(3):346-50.FM

Abstract

Patients infected through commercial blood-selling practices (former plasma donors, FPDs) in China represent a unique patient population compared to individuals infected through sexual contact or intravenous drug use. FPDs all have an approximate time of human immunodeficiency virus (HIV) infection during the mid-1990s. Few studies about the natural history of HIV infection in these patients were performed. The current study focuses on characterizing the duration of asymptomatic infection as well as the time to disease and mortality of infected FPDs in China. A retrospective cohort study was conducted based on data collected from 5484 HIV-1 infected FPDs in Shangcai county, Henan province. Kaplan-Meier analysis was applied to estimate the asymptomatic duration from the time of infection to the onset of AIDS as well as the survival period from the onset of AIDS to the time of death. The estimated median asymptomatic phase was about 9.21 years, which is similar to that reported in other developing countries in Africa. The estimated median life span after the onset of symptoms was about 9.91 months, which is notably shorter than life spans reported elsewhere. This is the first large-scale retrospective study on the natural history of HIV infection in FPDs in rural China. The findings not only provide valuable insight into an understudied population, but should also serve as an important reference for patient management and care.

Authors+Show Affiliations

Key Laboratory of AIDS Immunology, Ministry of Health, the First Hospital, China Medical University, Shenyang, 110001, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21191843

Citation

Zhang, Min, et al. "Natural History of HIV Infection in Former Plasma Donors in Rural China." Frontiers of Medicine in China, vol. 4, no. 3, 2010, pp. 346-50.
Zhang M, Shang H, Wang Z, et al. Natural history of HIV infection in former plasma donors in rural China. Front Med China. 2010;4(3):346-50.
Zhang, M., Shang, H., Wang, Z., Cui, W. G., & Hu, Q. H. (2010). Natural history of HIV infection in former plasma donors in rural China. Frontiers of Medicine in China, 4(3), 346-50. https://doi.org/10.1007/s11684-010-0102-x
Zhang M, et al. Natural History of HIV Infection in Former Plasma Donors in Rural China. Front Med China. 2010;4(3):346-50. PubMed PMID: 21191843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Natural history of HIV infection in former plasma donors in rural China. AU - Zhang,Min, AU - Shang,Hong, AU - Wang,Zhe, AU - Cui,Wei-Guo, AU - Hu,Qing-Hai, Y1 - 2010/08/12/ PY - 2010/06/03/received PY - 2010/06/12/accepted PY - 2010/12/31/entrez PY - 2010/12/31/pubmed PY - 2011/5/14/medline SP - 346 EP - 50 JF - Frontiers of medicine in China JO - Front Med China VL - 4 IS - 3 N2 - Patients infected through commercial blood-selling practices (former plasma donors, FPDs) in China represent a unique patient population compared to individuals infected through sexual contact or intravenous drug use. FPDs all have an approximate time of human immunodeficiency virus (HIV) infection during the mid-1990s. Few studies about the natural history of HIV infection in these patients were performed. The current study focuses on characterizing the duration of asymptomatic infection as well as the time to disease and mortality of infected FPDs in China. A retrospective cohort study was conducted based on data collected from 5484 HIV-1 infected FPDs in Shangcai county, Henan province. Kaplan-Meier analysis was applied to estimate the asymptomatic duration from the time of infection to the onset of AIDS as well as the survival period from the onset of AIDS to the time of death. The estimated median asymptomatic phase was about 9.21 years, which is similar to that reported in other developing countries in Africa. The estimated median life span after the onset of symptoms was about 9.91 months, which is notably shorter than life spans reported elsewhere. This is the first large-scale retrospective study on the natural history of HIV infection in FPDs in rural China. The findings not only provide valuable insight into an understudied population, but should also serve as an important reference for patient management and care. SN - 1673-7458 UR - https://www.unboundmedicine.com/medline/citation/21191843/Natural_history_of_HIV_infection_in_former_plasma_donors_in_rural_China. L2 - http://www.diseaseinfosearch.org/result/9735 DB - PRIME DP - Unbound Medicine ER -