Tags

Type your tag names separated by a space and hit enter

[Effect of CGRP receptor antagonist CGRP8-37 on nociceptive response, NOS expression and NO content in the dorsal horn of spinal cord during formalin-induced inflammatory pain in rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2004 Aug; 20(3):291-5.ZY

Abstract

AIM

To study the effect of CGRP receptor antagonist CGRP8-37 on nociceptive response and expression of nitric oxide synthase (NOS) and content of nitric oxide (NO) in the dorsal horn of the spinal cord of rats during formalin-induced inflammatory pain.

METHODS

Using formalin injection into right hind paw induced inflammatory pain. Counting the times of flinching reflex was used to observe the degree of spontaneous pain. NADPH-d histochemistry was used to observe the changes of NOS expression. The content of NO was observed by measuring the contents of nitrate/nitrite (NO3- / NO2-).

RESULTS

spontaneous pain behavioral was elicited by formalin injection. The NOS expression and NO content significantly increased in the spinal cord at 24 h after formalin injection. Intrathecal injection of CGRP8-37 could significantly inhibit the response of spontaneous pain and the increases of NOS expression and NO content induced by formalin injection.

CONCLUSION

The activation of CGRP receptors enhances NOS expression and NO production in the dorsal horn of the spinal cord during formalin-induced inflammatory pain.

Authors+Show Affiliations

Li TN
Department of Pathophysiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Li QJ
No affiliation info available
Li WB
No affiliation info available
Sun XC
No affiliation info available
Li SQ
No affiliation info available

MeSH

AnimalsCalcitonin Gene-Related PeptideCalcitonin Gene-Related Peptide Receptor AntagonistsFormaldehydeNitric OxideNitric Oxide SynthasePainPeptide FragmentsRatsRats, Sprague-DawleySpinal Cord

Pub Type(s)

Journal Article

Language

chi

PubMed ID

21192428

Citation

Li, Tong-nan, et al. "[Effect of CGRP Receptor Antagonist CGRP8-37 On Nociceptive Response, NOS Expression and NO Content in the Dorsal Horn of Spinal Cord During Formalin-induced Inflammatory Pain in Rats]." Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology, vol. 20, no. 3, 2004, pp. 291-5.
Li TN, Li QJ, Li WB, et al. [Effect of CGRP receptor antagonist CGRP8-37 on nociceptive response, NOS expression and NO content in the dorsal horn of spinal cord during formalin-induced inflammatory pain in rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2004;20(3):291-5.
Li, T. N., Li, Q. J., Li, W. B., Sun, X. C., & Li, S. Q. (2004). [Effect of CGRP receptor antagonist CGRP8-37 on nociceptive response, NOS expression and NO content in the dorsal horn of spinal cord during formalin-induced inflammatory pain in rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology, 20(3), 291-5.
Li TN, et al. [Effect of CGRP Receptor Antagonist CGRP8-37 On Nociceptive Response, NOS Expression and NO Content in the Dorsal Horn of Spinal Cord During Formalin-induced Inflammatory Pain in Rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2004;20(3):291-5. PubMed PMID: 21192428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of CGRP receptor antagonist CGRP8-37 on nociceptive response, NOS expression and NO content in the dorsal horn of spinal cord during formalin-induced inflammatory pain in rats]. AU - Li,Tong-nan, AU - Li,Qing-jun, AU - Li,Wen-bin, AU - Sun,Xiao-cai, AU - Li,Shu-qin, PY - 2011/1/1/entrez PY - 2004/8/1/pubmed PY - 2012/12/12/medline SP - 291 EP - 5 JF - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology JO - Zhongguo Ying Yong Sheng Li Xue Za Zhi VL - 20 IS - 3 N2 - AIM: To study the effect of CGRP receptor antagonist CGRP8-37 on nociceptive response and expression of nitric oxide synthase (NOS) and content of nitric oxide (NO) in the dorsal horn of the spinal cord of rats during formalin-induced inflammatory pain. METHODS: Using formalin injection into right hind paw induced inflammatory pain. Counting the times of flinching reflex was used to observe the degree of spontaneous pain. NADPH-d histochemistry was used to observe the changes of NOS expression. The content of NO was observed by measuring the contents of nitrate/nitrite (NO3- / NO2-). RESULTS: spontaneous pain behavioral was elicited by formalin injection. The NOS expression and NO content significantly increased in the spinal cord at 24 h after formalin injection. Intrathecal injection of CGRP8-37 could significantly inhibit the response of spontaneous pain and the increases of NOS expression and NO content induced by formalin injection. CONCLUSION: The activation of CGRP receptors enhances NOS expression and NO production in the dorsal horn of the spinal cord during formalin-induced inflammatory pain. SN - 1000-6834 UR - https://www.unboundmedicine.com/medline/citation/21192428/[Effect_of_CGRP_receptor_antagonist_CGRP8_37_on_nociceptive_response_NOS_expression_and_NO_content_in_the_dorsal_horn_of_spinal_cord_during_formalin_induced_inflammatory_pain_in_rats]_ L2 - https://medlineplus.gov/pain.html DB - PRIME DP - Unbound Medicine ER -