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Alteration of the endocannabinoid system in mouse brain during prion disease.
Neuroscience 2011; 177:292-7N

Abstract

Prion diseases are neurodegenerative disorders characterized by deposition of the pathological prion protein (PrPsc) within the brain of affected humans and animals. Microglial cell activation is a common feature of prion diseases; alterations of various neurotransmitter systems and neurotransmission have been also reported. Owing to its ability to modulate both neuroimmune responses and neurotransmission, it was of interest to study the brain endocannabinoid system in a prion-infected mouse model. The production of the endocannabinoid, 2-arachidonoyglycerol (2-AG), was enhanced 10 weeks post-infection, without alteration of the other endocannabinoid, anandamide. The CB2 receptor expression was up-regulated in brains of prion-infected mice as early as 10 weeks and up to 32 weeks post-infection whereas the mRNAs of other cannabinoid receptors (CBRs) remain unchanged. The observed alterations of the endocannabinoid system were specific for prion infection since no significant changes were observed in the brain of prion-resistant mice, that is, mice devoid of the Prnp gene. Our study highlights important alterations of the endocannabinoid system during early stages of the disease long before the clinical signs of the disease.

Authors+Show Affiliations

Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, CNR Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli (NA), Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21195746

Citation

Petrosino, S, et al. "Alteration of the Endocannabinoid System in Mouse Brain During Prion Disease." Neuroscience, vol. 177, 2011, pp. 292-7.
Petrosino S, Ménard B, Zsürger N, et al. Alteration of the endocannabinoid system in mouse brain during prion disease. Neuroscience. 2011;177:292-7.
Petrosino, S., Ménard, B., Zsürger, N., Di Marzo, V., & Chabry, J. (2011). Alteration of the endocannabinoid system in mouse brain during prion disease. Neuroscience, 177, pp. 292-7. doi:10.1016/j.neuroscience.2010.12.046.
Petrosino S, et al. Alteration of the Endocannabinoid System in Mouse Brain During Prion Disease. Neuroscience. 2011 Mar 17;177:292-7. PubMed PMID: 21195746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alteration of the endocannabinoid system in mouse brain during prion disease. AU - Petrosino,S, AU - Ménard,B, AU - Zsürger,N, AU - Di Marzo,V, AU - Chabry,J, Y1 - 2010/12/31/ PY - 2010/11/17/received PY - 2010/12/22/revised PY - 2010/12/24/accepted PY - 2011/1/4/entrez PY - 2011/1/5/pubmed PY - 2012/1/20/medline SP - 292 EP - 7 JF - Neuroscience JO - Neuroscience VL - 177 N2 - Prion diseases are neurodegenerative disorders characterized by deposition of the pathological prion protein (PrPsc) within the brain of affected humans and animals. Microglial cell activation is a common feature of prion diseases; alterations of various neurotransmitter systems and neurotransmission have been also reported. Owing to its ability to modulate both neuroimmune responses and neurotransmission, it was of interest to study the brain endocannabinoid system in a prion-infected mouse model. The production of the endocannabinoid, 2-arachidonoyglycerol (2-AG), was enhanced 10 weeks post-infection, without alteration of the other endocannabinoid, anandamide. The CB2 receptor expression was up-regulated in brains of prion-infected mice as early as 10 weeks and up to 32 weeks post-infection whereas the mRNAs of other cannabinoid receptors (CBRs) remain unchanged. The observed alterations of the endocannabinoid system were specific for prion infection since no significant changes were observed in the brain of prion-resistant mice, that is, mice devoid of the Prnp gene. Our study highlights important alterations of the endocannabinoid system during early stages of the disease long before the clinical signs of the disease. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/21195746/abstract/Alteration_of_the_Endocannabi L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(10)01651-9 DB - PRIME DP - Unbound Medicine ER -