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Thyroperoxidase, thyroglobulin, Na(+)/I(-) symporter, pendrin in thyroid autoimmunity.
Front Biosci (Landmark Ed). 2011 Jan 01; 16:783-802.FB

Abstract

The autoimmune thyroid diseases (AITD), Graves' disease (GD) and Hashimoto's thyroiditis (HT) are most common endocrine disorders in humans. Both disorders are characterized by lymphocytic infiltration of the thyroid gland and the production of autoantibodies (aAb) against proteins that are thyroid-specific or expressed predominantly in the thyroid. The three main autoantigens are thyroperoxidase (TPO), thyroglobulin (Tg), and thyrotropin hormone receptor. Recently, the thyroidal iodide transporters Na+/I- symporter (NIS) and pendrin have also been identified as novel antigens in AITD. TPO-aAb and Tg-aAb are hallmarks of AITD, whereas the pathological and clinical relevance of NIS and pendrin aAb are still uncertain. To gain a greater understanding of the pathogenic mechanism(s) of autoimmune thyroid diseases at the molecular level, further characterisation of the autoantigens is required in order to shed light on why and how these molecules are seen by the immune system. This review summarizes current knowledge regarding the patho-physiological function and immunogenic response to the proteins TPO, Tg, NIS, and pendrin.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, Medical Center of Postgraduate Education, 99/103 Marymoncka Street, 01-813 Warsaw, Poland. barbarac@cmkp.edu.pl

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21196203

Citation

Czarnocka, Barbara. "Thyroperoxidase, Thyroglobulin, Na(+)/I(-) Symporter, Pendrin in Thyroid Autoimmunity." Frontiers in Bioscience (Landmark Edition), vol. 16, 2011, pp. 783-802.
Czarnocka B. Thyroperoxidase, thyroglobulin, Na(+)/I(-) symporter, pendrin in thyroid autoimmunity. Front Biosci (Landmark Ed). 2011;16:783-802.
Czarnocka, B. (2011). Thyroperoxidase, thyroglobulin, Na(+)/I(-) symporter, pendrin in thyroid autoimmunity. Frontiers in Bioscience (Landmark Edition), 16, 783-802.
Czarnocka B. Thyroperoxidase, Thyroglobulin, Na(+)/I(-) Symporter, Pendrin in Thyroid Autoimmunity. Front Biosci (Landmark Ed). 2011 Jan 1;16:783-802. PubMed PMID: 21196203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyroperoxidase, thyroglobulin, Na(+)/I(-) symporter, pendrin in thyroid autoimmunity. A1 - Czarnocka,Barbara, Y1 - 2011/01/01/ PY - 2011/1/4/entrez PY - 2011/1/5/pubmed PY - 2011/4/22/medline SP - 783 EP - 802 JF - Frontiers in bioscience (Landmark edition) JO - Front Biosci (Landmark Ed) VL - 16 N2 - The autoimmune thyroid diseases (AITD), Graves' disease (GD) and Hashimoto's thyroiditis (HT) are most common endocrine disorders in humans. Both disorders are characterized by lymphocytic infiltration of the thyroid gland and the production of autoantibodies (aAb) against proteins that are thyroid-specific or expressed predominantly in the thyroid. The three main autoantigens are thyroperoxidase (TPO), thyroglobulin (Tg), and thyrotropin hormone receptor. Recently, the thyroidal iodide transporters Na+/I- symporter (NIS) and pendrin have also been identified as novel antigens in AITD. TPO-aAb and Tg-aAb are hallmarks of AITD, whereas the pathological and clinical relevance of NIS and pendrin aAb are still uncertain. To gain a greater understanding of the pathogenic mechanism(s) of autoimmune thyroid diseases at the molecular level, further characterisation of the autoantigens is required in order to shed light on why and how these molecules are seen by the immune system. This review summarizes current knowledge regarding the patho-physiological function and immunogenic response to the proteins TPO, Tg, NIS, and pendrin. SN - 1093-4715 UR - https://www.unboundmedicine.com/medline/citation/21196203/Thyroperoxidase_thyroglobulin_Na_+_/I____symporter_pendrin_in_thyroid_autoimmunity_ L2 - https://www.bioscience.org/2011/v16/af/3720/fulltext.htm DB - PRIME DP - Unbound Medicine ER -