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Longitudinal association between IGFBP-1 levels and parameters of the metabolic syndrome in obese children before and after weight loss.
Int J Pediatr Obes. 2011 Aug; 6(3-4):236-43.IJ

Abstract

BACKGROUND

Insulin-like growth factor binding protein 1 (IGFBP-1) is a marker of insulin resistance. We hypothesized that IGFBP-1 is associated with the metabolic syndrome (MetS), which is related to insulin resistance.

METHODS

We examined 51 obese Caucasian children (mean age 12.1 ? 2.3, 55% male, mean body mass index [BMI] 31.8 ? 4.8 kg/m(2)). Anthropometrical markers, pubertal stage, hepatic ultrasound, waist circumference, blood pressure, fasting serum IGFBP-1, IGFBP-3, IGF-I, adiponectin, leptin, transaminases, glucose, insulin, triglycerides, and HDL-cholesterol concentrations were determined at onset and the end of the one-year lifestyle intervention.

RESULTS

In contrast to IGF-I and IGFBP-3, IGFBP-1 correlated significantly to most parameters of the MetS in cross-sectional (waist circumference: r = -0.45, triglycerides: r = -0.29; insulin: r = -0.31; HOMA: r = -0.30) and longitudinal analyses (? triglycerides: r = ?0.22; ? Insulin: r = ?0.25; ? HOMA: r = ?0.62). The association between changes of HOMA and changes of IGFBP-1 was stronger than the associations between changes of leptin or adiponectin, and changes of HOMA. The risk for the MetS was inversely related to IGFBP-1 levels (odds ratio:-0.05 per additional IGFBP-1 unit; 95% confidence interval: -0.08 up to -0.02; p = 0.019) in a multiple logistic regression analyses adjusted to BMI, pubertal stage, age, and gender. The nine obese children with the MetS had significantly lower IGFBP-1 levels (1.6 ? 1.3 ngm/l) than the 42 obese children without the MetS (4.0 ? 3.8 ng/ml). The eleven obese children with fatty liver assessed by ultrasound had significantly lower IGFBP-1 levels (1.5 ? 1.3 ngm/l) than the 40 obese children without fatty liver (4.2 ? 4.1 ng/ml).

CONCLUSION

The strong relationships between IGFBP-1, insulin resistance, and the MetS suggest that IGFBP-1 might be a promising marker for these entities in obesity. This study is registered at clinicaltrials.gov (NCT00435734).

Authors+Show Affiliations

Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke , Germany. T.Reinehr@kinderklinik-datteln.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

21198359

Citation

Reinehr, Thomas, et al. "Longitudinal Association Between IGFBP-1 Levels and Parameters of the Metabolic Syndrome in Obese Children Before and After Weight Loss." International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity, vol. 6, no. 3-4, 2011, pp. 236-43.
Reinehr T, Kleber M, Toschke AM, et al. Longitudinal association between IGFBP-1 levels and parameters of the metabolic syndrome in obese children before and after weight loss. Int J Pediatr Obes. 2011;6(3-4):236-43.
Reinehr, T., Kleber, M., Toschke, A. M., Woelfle, J., & Roth, C. L. (2011). Longitudinal association between IGFBP-1 levels and parameters of the metabolic syndrome in obese children before and after weight loss. International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity, 6(3-4), 236-43. https://doi.org/10.3109/17477166.2010.544739
Reinehr T, et al. Longitudinal Association Between IGFBP-1 Levels and Parameters of the Metabolic Syndrome in Obese Children Before and After Weight Loss. Int J Pediatr Obes. 2011;6(3-4):236-43. PubMed PMID: 21198359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal association between IGFBP-1 levels and parameters of the metabolic syndrome in obese children before and after weight loss. AU - Reinehr,Thomas, AU - Kleber,Michaela, AU - Toschke,Andre Michael, AU - Woelfle,Joachim, AU - Roth,Christian L, Y1 - 2011/01/03/ PY - 2011/1/5/entrez PY - 2011/1/5/pubmed PY - 2011/11/15/medline SP - 236 EP - 43 JF - International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity JO - Int J Pediatr Obes VL - 6 IS - 3-4 N2 - BACKGROUND: Insulin-like growth factor binding protein 1 (IGFBP-1) is a marker of insulin resistance. We hypothesized that IGFBP-1 is associated with the metabolic syndrome (MetS), which is related to insulin resistance. METHODS: We examined 51 obese Caucasian children (mean age 12.1 ? 2.3, 55% male, mean body mass index [BMI] 31.8 ? 4.8 kg/m(2)). Anthropometrical markers, pubertal stage, hepatic ultrasound, waist circumference, blood pressure, fasting serum IGFBP-1, IGFBP-3, IGF-I, adiponectin, leptin, transaminases, glucose, insulin, triglycerides, and HDL-cholesterol concentrations were determined at onset and the end of the one-year lifestyle intervention. RESULTS: In contrast to IGF-I and IGFBP-3, IGFBP-1 correlated significantly to most parameters of the MetS in cross-sectional (waist circumference: r = -0.45, triglycerides: r = -0.29; insulin: r = -0.31; HOMA: r = -0.30) and longitudinal analyses (? triglycerides: r = ?0.22; ? Insulin: r = ?0.25; ? HOMA: r = ?0.62). The association between changes of HOMA and changes of IGFBP-1 was stronger than the associations between changes of leptin or adiponectin, and changes of HOMA. The risk for the MetS was inversely related to IGFBP-1 levels (odds ratio:-0.05 per additional IGFBP-1 unit; 95% confidence interval: -0.08 up to -0.02; p = 0.019) in a multiple logistic regression analyses adjusted to BMI, pubertal stage, age, and gender. The nine obese children with the MetS had significantly lower IGFBP-1 levels (1.6 ? 1.3 ngm/l) than the 42 obese children without the MetS (4.0 ? 3.8 ng/ml). The eleven obese children with fatty liver assessed by ultrasound had significantly lower IGFBP-1 levels (1.5 ? 1.3 ngm/l) than the 40 obese children without fatty liver (4.2 ? 4.1 ng/ml). CONCLUSION: The strong relationships between IGFBP-1, insulin resistance, and the MetS suggest that IGFBP-1 might be a promising marker for these entities in obesity. This study is registered at clinicaltrials.gov (NCT00435734). SN - 1747-7174 UR - https://www.unboundmedicine.com/medline/citation/21198359/Longitudinal_association_between_IGFBP_1_levels_and_parameters_of_the_metabolic_syndrome_in_obese_children_before_and_after_weight_loss_ DB - PRIME DP - Unbound Medicine ER -