Tags

Type your tag names separated by a space and hit enter

Dopaminergic mechanisms of reinstatement of MDMA-seeking behaviour in rats.
Br J Pharmacol. 2011 Apr; 162(8):1770-80.BJ

Abstract

BACKGROUND AND PURPOSE

Animal models of drug-seeking suggest that exposure to cues associated with self-administered drugs and drug primes might precipitate relapse via activation of central dopaminergic substrates.

EXPERIMENTAL APPROACH

The effects of priming injections of dopamine and 5-HT agonists on drug-seeking and effects of dopamine antagonists on methylenedioxymethamphetamine (MDMA)-produced potentiation of drug-seeking following extinguished MDMA self-administration were examined.

KEY RESULTS

Drug-seeking was produced by exposure to a light stimulus that had been paired with self-administered MDMA infusions and this effect was potentiated by experimenter-administered injections of the dopamine D(2) -like receptor agonist, quinpirole, the indirect agonist, amphetamine and the uptake inhibitor, GBR 12909. Drug-seeking was not elicited by the dopamine D(1) -like receptor agonist, SKF 81297 or the non-selective agonist, apomorphine. The 5-HT receptor agonists DOI or mCPP also failed to elicit drug-seeking. The 5-HT uptake inhibitor, clomipramine, attenuated drug-seeking produced by the MDMA-associated stimulus but failed to alter the potentiated response produced by GBR 12909. The D(1) receptor antagonist, SCH 23390 or the D(2) receptor antagonist, eticlopride attenuated the potentiation of drug-seeking produced by MDMA.

CONCLUSIONS AND IMPLICATIONS

These data provide evidence of dopaminergic mechanisms in drug-seeking following extinction of MDMA self-administration. Because tissue levels of 5-HT were significantly decreased following MDMA self-administration, we suggest that MDMA begins to preferentially activate dopaminergic substrates to potentiate the drug-seeking response.

Authors+Show Affiliations

Victoria University of Wellington, School of Psychology, Wellington, New Zealand. susan.schenk@vuw.ac.nzNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21198550

Citation

Schenk, S, et al. "Dopaminergic Mechanisms of Reinstatement of MDMA-seeking Behaviour in Rats." British Journal of Pharmacology, vol. 162, no. 8, 2011, pp. 1770-80.
Schenk S, Gittings D, Colussi-Mas J. Dopaminergic mechanisms of reinstatement of MDMA-seeking behaviour in rats. Br J Pharmacol. 2011;162(8):1770-80.
Schenk, S., Gittings, D., & Colussi-Mas, J. (2011). Dopaminergic mechanisms of reinstatement of MDMA-seeking behaviour in rats. British Journal of Pharmacology, 162(8), 1770-80. https://doi.org/10.1111/j.1476-5381.2010.01193.x
Schenk S, Gittings D, Colussi-Mas J. Dopaminergic Mechanisms of Reinstatement of MDMA-seeking Behaviour in Rats. Br J Pharmacol. 2011;162(8):1770-80. PubMed PMID: 21198550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopaminergic mechanisms of reinstatement of MDMA-seeking behaviour in rats. AU - Schenk,S, AU - Gittings,D, AU - Colussi-Mas,J, PY - 2011/1/5/entrez PY - 2011/1/5/pubmed PY - 2011/7/19/medline SP - 1770 EP - 80 JF - British journal of pharmacology JO - Br. J. Pharmacol. VL - 162 IS - 8 N2 - BACKGROUND AND PURPOSE: Animal models of drug-seeking suggest that exposure to cues associated with self-administered drugs and drug primes might precipitate relapse via activation of central dopaminergic substrates. EXPERIMENTAL APPROACH: The effects of priming injections of dopamine and 5-HT agonists on drug-seeking and effects of dopamine antagonists on methylenedioxymethamphetamine (MDMA)-produced potentiation of drug-seeking following extinguished MDMA self-administration were examined. KEY RESULTS: Drug-seeking was produced by exposure to a light stimulus that had been paired with self-administered MDMA infusions and this effect was potentiated by experimenter-administered injections of the dopamine D(2) -like receptor agonist, quinpirole, the indirect agonist, amphetamine and the uptake inhibitor, GBR 12909. Drug-seeking was not elicited by the dopamine D(1) -like receptor agonist, SKF 81297 or the non-selective agonist, apomorphine. The 5-HT receptor agonists DOI or mCPP also failed to elicit drug-seeking. The 5-HT uptake inhibitor, clomipramine, attenuated drug-seeking produced by the MDMA-associated stimulus but failed to alter the potentiated response produced by GBR 12909. The D(1) receptor antagonist, SCH 23390 or the D(2) receptor antagonist, eticlopride attenuated the potentiation of drug-seeking produced by MDMA. CONCLUSIONS AND IMPLICATIONS: These data provide evidence of dopaminergic mechanisms in drug-seeking following extinction of MDMA self-administration. Because tissue levels of 5-HT were significantly decreased following MDMA self-administration, we suggest that MDMA begins to preferentially activate dopaminergic substrates to potentiate the drug-seeking response. SN - 1476-5381 UR - https://www.unboundmedicine.com/medline/citation/21198550/Dopaminergic_mechanisms_of_reinstatement_of_MDMA_seeking_behaviour_in_rats_ L2 - https://doi.org/10.1111/j.1476-5381.2010.01193.x DB - PRIME DP - Unbound Medicine ER -