Tags

Type your tag names separated by a space and hit enter

Pandemic influenza A/H1N1 vaccine administered sequentially or simultaneously with seasonal influenza vaccine to HIV-infected children and adolescents.
Vaccine 2011; 29(8):1677-82V

Abstract

In order to evaluate the immunogenicity, safety and tolerability of the 2009 A/H1N1 MF59-adjuvanted influenza vaccine administered sequentially or simultaneously with seasonal virosomal-adjuvanted influenza vaccine to HIV-infected children and adolescents, 36 HIV-infected children and adolescents, and 36 age- and gender-matched healthy controls were randomised 1:1 to receive the pandemic vaccine upon enrollment and the seasonal vaccine one month later, or to receive the pandemic and seasonal vaccines simultaneously upon enrollment. Seroconversion and seroprotection rates against the pandemic influenza A/H1N1 virus were 100% two months after vaccine administration in both groups, regardless of the sequence of administration. Geometric mean titres against pandemic and seasonal antigens were significantly higher when the seasonal and pandemic vaccines were administered simultaneously than when the seasonal vaccine was administered alone. Local and systemic reactions were mild and not increased by simultaneous administration. In conclusion, the 2009 pandemic influenza A/H1N1 MF59-adjuvanted vaccine is as immunogenic, safe and well tolerated in HIV-infected children and adolescents as in healthy controls. Its simultaneous administration with virosomal-adjuvanted seasonal antigens seems to increase immune response to both pandemic and seasonal viruses with the same safety profile as that of the pandemic vaccine alone. However, because this finding cannot be clearly explained by an immunological viewpoint, further studies are needed to clarify the reasons of its occurrence.

Authors+Show Affiliations

Department of Maternal and Pediatric Sciences, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21199699

Citation

Esposito, Susanna, et al. "Pandemic Influenza A/H1N1 Vaccine Administered Sequentially or Simultaneously With Seasonal Influenza Vaccine to HIV-infected Children and Adolescents." Vaccine, vol. 29, no. 8, 2011, pp. 1677-82.
Esposito S, Tagliaferri L, Daleno C, et al. Pandemic influenza A/H1N1 vaccine administered sequentially or simultaneously with seasonal influenza vaccine to HIV-infected children and adolescents. Vaccine. 2011;29(8):1677-82.
Esposito, S., Tagliaferri, L., Daleno, C., Valzano, A., Picciolli, I., Tel, F., ... Principi, N. (2011). Pandemic influenza A/H1N1 vaccine administered sequentially or simultaneously with seasonal influenza vaccine to HIV-infected children and adolescents. Vaccine, 29(8), pp. 1677-82. doi:10.1016/j.vaccine.2010.12.047.
Esposito S, et al. Pandemic Influenza A/H1N1 Vaccine Administered Sequentially or Simultaneously With Seasonal Influenza Vaccine to HIV-infected Children and Adolescents. Vaccine. 2011 Feb 11;29(8):1677-82. PubMed PMID: 21199699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pandemic influenza A/H1N1 vaccine administered sequentially or simultaneously with seasonal influenza vaccine to HIV-infected children and adolescents. AU - Esposito,Susanna, AU - Tagliaferri,Laura, AU - Daleno,Cristina, AU - Valzano,Antonia, AU - Picciolli,Irene, AU - Tel,Francesca, AU - Prunotto,Giulia, AU - Serra,Domenico, AU - Galeone,Carlotta, AU - Plebani,Anna, AU - Principi,Nicola, Y1 - 2011/01/01/ PY - 2010/09/20/received PY - 2010/11/29/revised PY - 2010/12/14/accepted PY - 2011/1/5/entrez PY - 2011/1/5/pubmed PY - 2011/4/20/medline SP - 1677 EP - 82 JF - Vaccine JO - Vaccine VL - 29 IS - 8 N2 - In order to evaluate the immunogenicity, safety and tolerability of the 2009 A/H1N1 MF59-adjuvanted influenza vaccine administered sequentially or simultaneously with seasonal virosomal-adjuvanted influenza vaccine to HIV-infected children and adolescents, 36 HIV-infected children and adolescents, and 36 age- and gender-matched healthy controls were randomised 1:1 to receive the pandemic vaccine upon enrollment and the seasonal vaccine one month later, or to receive the pandemic and seasonal vaccines simultaneously upon enrollment. Seroconversion and seroprotection rates against the pandemic influenza A/H1N1 virus were 100% two months after vaccine administration in both groups, regardless of the sequence of administration. Geometric mean titres against pandemic and seasonal antigens were significantly higher when the seasonal and pandemic vaccines were administered simultaneously than when the seasonal vaccine was administered alone. Local and systemic reactions were mild and not increased by simultaneous administration. In conclusion, the 2009 pandemic influenza A/H1N1 MF59-adjuvanted vaccine is as immunogenic, safe and well tolerated in HIV-infected children and adolescents as in healthy controls. Its simultaneous administration with virosomal-adjuvanted seasonal antigens seems to increase immune response to both pandemic and seasonal viruses with the same safety profile as that of the pandemic vaccine alone. However, because this finding cannot be clearly explained by an immunological viewpoint, further studies are needed to clarify the reasons of its occurrence. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21199699/Pandemic_influenza_A/H1N1_vaccine_administered_sequentially_or_simultaneously_with_seasonal_influenza_vaccine_to_HIV_infected_children_and_adolescents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(10)01820-7 DB - PRIME DP - Unbound Medicine ER -