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Damaging role of neutrophil elastase in the elastic fiber and basement membrane in human emphysematous lung.
Chin Med J (Engl). 1990 Jul; 103(7):588-94.CM

Abstract

The immunolocalization of human neutrophil elastase (HNE) in the alveolar interstitium of 6 patients with emphysema was investigated by immunochemical electron microscopy. The results showed that HNE is localized in the azurophil granules of neutrophils, and extracellularly on the elastic fibers of alveolar interstitium and basement membranes of epithelium and endothelium. The damage of elastic fibers and basement membranes could be observed. The HNE level of the alveolar interstitium was obviously elevated and closely related to the severity of emphysematous lesions as shown by measuring the mean linear intercept (MLI) in 4 emphysematous lungs with chronic bronchitis (r = 0.84). This suggests that HNE might play an important role in the pathogenesis of emphysema. Although enlarged airspace and increased MLI data were observed in 2 patients, one with asthma and the other, an elderly patient, without lung diseases, the HNE level of alveolar interstitium is much less than that of the other 4 chronic obstructive pulmonary disease patients. This implies that the mechanism of the the airspace enlargement occurring in the 2 patients may be different from that of others. These findings support the hypothesis of elastase-antielastase imbalance on the pathogenesis of pulmonary emphysema.

Authors+Show Affiliations

Ge YM
Peking Union Medical College Hospital, Beijing.
Zhu YJ
No affiliation info available
Luo WC
No affiliation info available
Gong YH
No affiliation info available
Zhang XQ
No affiliation info available

MeSH

AdultBasement MembraneElastic TissueFemaleHumansLungMaleMiddle AgedNeutrophilsPancreatic ElastasePulmonary Emphysema

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2119977

Citation

Ge, Y M., et al. "Damaging Role of Neutrophil Elastase in the Elastic Fiber and Basement Membrane in Human Emphysematous Lung." Chinese Medical Journal, vol. 103, no. 7, 1990, pp. 588-94.
Ge YM, Zhu YJ, Luo WC, et al. Damaging role of neutrophil elastase in the elastic fiber and basement membrane in human emphysematous lung. Chin Med J (Engl). 1990;103(7):588-94.
Ge, Y. M., Zhu, Y. J., Luo, W. C., Gong, Y. H., & Zhang, X. Q. (1990). Damaging role of neutrophil elastase in the elastic fiber and basement membrane in human emphysematous lung. Chinese Medical Journal, 103(7), 588-94.
Ge YM, et al. Damaging Role of Neutrophil Elastase in the Elastic Fiber and Basement Membrane in Human Emphysematous Lung. Chin Med J (Engl). 1990;103(7):588-94. PubMed PMID: 2119977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Damaging role of neutrophil elastase in the elastic fiber and basement membrane in human emphysematous lung. AU - Ge,Y M, AU - Zhu,Y J, AU - Luo,W C, AU - Gong,Y H, AU - Zhang,X Q, PY - 1990/7/1/pubmed PY - 1990/7/1/medline PY - 1990/7/1/entrez SP - 588 EP - 94 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 103 IS - 7 N2 - The immunolocalization of human neutrophil elastase (HNE) in the alveolar interstitium of 6 patients with emphysema was investigated by immunochemical electron microscopy. The results showed that HNE is localized in the azurophil granules of neutrophils, and extracellularly on the elastic fibers of alveolar interstitium and basement membranes of epithelium and endothelium. The damage of elastic fibers and basement membranes could be observed. The HNE level of the alveolar interstitium was obviously elevated and closely related to the severity of emphysematous lesions as shown by measuring the mean linear intercept (MLI) in 4 emphysematous lungs with chronic bronchitis (r = 0.84). This suggests that HNE might play an important role in the pathogenesis of emphysema. Although enlarged airspace and increased MLI data were observed in 2 patients, one with asthma and the other, an elderly patient, without lung diseases, the HNE level of alveolar interstitium is much less than that of the other 4 chronic obstructive pulmonary disease patients. This implies that the mechanism of the the airspace enlargement occurring in the 2 patients may be different from that of others. These findings support the hypothesis of elastase-antielastase imbalance on the pathogenesis of pulmonary emphysema. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/2119977/Damaging_role_of_neutrophil_elastase_in_the_elastic_fiber_and_basement_membrane_in_human_emphysematous_lung_ DB - PRIME DP - Unbound Medicine ER -