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Influence of blood glucose on heart rate and cardiac autonomic function. The DESIR study.
Diabet Med. 2011 Apr; 28(4):440-9.DM

Abstract

OBJECTIVES

To evaluate in a general population, the relationships between dysglycaemia, insulin resistance and metabolic variables, and heart rate, heart rate recovery and heart rate variability.

METHODS

Four hundred and forty-seven participants in the Data from an Epidemiological Study on the Insulin Resistance syndrome (DESIR) study were classified according to glycaemic status over the preceding 9 years. All were free of self-reported cardiac antecedents and were not taking drugs which alter heart rate. During five consecutive periods: rest, deep breathing, recovery, rest and lying to standing, heart rate and heart rate varability were evaluated and compared by ANCOVA and trend tests across glycaemic classes. Spearman correlation coefficients quantified the relations between cardio-metabolic risk factors, heart rate and heart rate varability.

RESULTS

Heart rate differed between glycaemic groups, except during deep breathing. Between rest and deep-breathing periods, patients with diabetes had a lower increase in heart rate than others (P(trend) < 0.01); between deep breathing and recovery, the heart rate of patients with diabetes continued to increase, for others, heart rate decreased (P(trend) < 0.009). Heart rate was correlated with capillary glucose and triglycerides during the five test periods. Heart rate variability differed according to glycaemic status, especially during the recovery period. After age, sex and BMI adjustment, heart rate variability was correlated with triglycerides at two test periods. Change in heart rate between recovery and deep breathing was negatively correlated with heart rate variability at rest, (r=-0.113, P < 0.05): lower resting heart rate variability was associated with heart rate acceleration.

CONCLUSIONS

Heart rate, but not heart rate variability, was associated with glycaemic status and capillary glucose. After deep breathing, heart rate recovery was altered in patients with known diabetes and was associated with reduced heart rate variability. Being overweight was a major correlate of heart rate variability.

Authors+Show Affiliations

Department of Endocrinology-Diabetology-Nutrition, Paris-Nord University, Jean Verdier Hospital, Bondy, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21204961

Citation

Valensi, P, et al. "Influence of Blood Glucose On Heart Rate and Cardiac Autonomic Function. the DESIR Study." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 28, no. 4, 2011, pp. 440-9.
Valensi P, Extramiana F, Lange C, et al. Influence of blood glucose on heart rate and cardiac autonomic function. The DESIR study. Diabet Med. 2011;28(4):440-9.
Valensi, P., Extramiana, F., Lange, C., Cailleau, M., Haggui, A., Maison Blanche, P., Tichet, J., & Balkau, B. (2011). Influence of blood glucose on heart rate and cardiac autonomic function. The DESIR study. Diabetic Medicine : a Journal of the British Diabetic Association, 28(4), 440-9. https://doi.org/10.1111/j.1464-5491.2010.03222.x
Valensi P, et al. Influence of Blood Glucose On Heart Rate and Cardiac Autonomic Function. the DESIR Study. Diabet Med. 2011;28(4):440-9. PubMed PMID: 21204961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of blood glucose on heart rate and cardiac autonomic function. The DESIR study. AU - Valensi,P, AU - Extramiana,F, AU - Lange,C, AU - Cailleau,M, AU - Haggui,A, AU - Maison Blanche,P, AU - Tichet,J, AU - Balkau,B, AU - ,, PY - 2011/1/6/entrez PY - 2011/1/6/pubmed PY - 2011/6/24/medline SP - 440 EP - 9 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 28 IS - 4 N2 - OBJECTIVES: To evaluate in a general population, the relationships between dysglycaemia, insulin resistance and metabolic variables, and heart rate, heart rate recovery and heart rate variability. METHODS: Four hundred and forty-seven participants in the Data from an Epidemiological Study on the Insulin Resistance syndrome (DESIR) study were classified according to glycaemic status over the preceding 9 years. All were free of self-reported cardiac antecedents and were not taking drugs which alter heart rate. During five consecutive periods: rest, deep breathing, recovery, rest and lying to standing, heart rate and heart rate varability were evaluated and compared by ANCOVA and trend tests across glycaemic classes. Spearman correlation coefficients quantified the relations between cardio-metabolic risk factors, heart rate and heart rate varability. RESULTS: Heart rate differed between glycaemic groups, except during deep breathing. Between rest and deep-breathing periods, patients with diabetes had a lower increase in heart rate than others (P(trend) < 0.01); between deep breathing and recovery, the heart rate of patients with diabetes continued to increase, for others, heart rate decreased (P(trend) < 0.009). Heart rate was correlated with capillary glucose and triglycerides during the five test periods. Heart rate variability differed according to glycaemic status, especially during the recovery period. After age, sex and BMI adjustment, heart rate variability was correlated with triglycerides at two test periods. Change in heart rate between recovery and deep breathing was negatively correlated with heart rate variability at rest, (r=-0.113, P < 0.05): lower resting heart rate variability was associated with heart rate acceleration. CONCLUSIONS: Heart rate, but not heart rate variability, was associated with glycaemic status and capillary glucose. After deep breathing, heart rate recovery was altered in patients with known diabetes and was associated with reduced heart rate variability. Being overweight was a major correlate of heart rate variability. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/21204961/Influence_of_blood_glucose_on_heart_rate_and_cardiac_autonomic_function__The_DESIR_study_ L2 - https://doi.org/10.1111/j.1464-5491.2010.03222.x DB - PRIME DP - Unbound Medicine ER -