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Diabetes is an inflammatory disease: evidence from traditional Chinese medicines.
Diabetes Obes Metab. 2011 Apr; 13(4):289-301.DO

Abstract

Diabetes is usually associated with inflammation. Inflammation contributes to the development of diabetes. Traditional Chinese medicines (TCM) play an important role in lowering blood glucose and controlling inflammation. Many studies show that TCM with hypoglycaemic effects, for example Radix Astragali, Radix Rehmanniae, Radix Trichosanthis, Panax Ginseng, Fructus Schisandrae, Radix Ophiopogonis, Rhizoma Anemarrhenae, Radix Puerariae, Fructus Lycii, Poria, Rhizoma Coptidis, Rhizoma Dioscoreae, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Semen Trigonellae, Momordica charantia, Allium sativum, Opuntia stricta, Aloe vera, Cortex Cinnamomi, Rhizoma Curcumae Longae, and so on, have nearly independent anti-inflammatory action. Antihyperglycaemic compounds, for example berberine, puerarin, quercetin, ferulic acid, astragaloside IV, curcumin, epigallocatechin gallate, resveratrol, tetrandrine, glycyrrhizin, emodin and baicalin, used in TCM also have anti-inflammatory effects. These studies suggest that TCM might exert hypoglycaemic effects that are partly mediated by the anti-inflammatory mechanisms. However, small amounts of TCM with potent anti-inflammatory action does not have any hypoglycaemic effect. This indirectly indicates that diabetes may be a low-grade inflammatory disease and potent regulation of inflammatory mediators may not be required. Studies of TCM add new evidences, which indicate that diabetes may be an inflammatory disease and slight or moderate inhibition of inflammation might be useful to prevent the development of diabetes. Through this review, we aim to develop more perspectives to indicate that diabetes may be an inflammatory disease and diverse TCM may share a common antidiabetic property: anti-inflammatory action. Further studies should focus on and validate inflammation-regulating targets of TCM that may be involved in inhibiting the development of diabetes.

Authors+Show Affiliations

Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21205111

Citation

Xie, W, and L Du. "Diabetes Is an Inflammatory Disease: Evidence From Traditional Chinese Medicines." Diabetes, Obesity & Metabolism, vol. 13, no. 4, 2011, pp. 289-301.
Xie W, Du L. Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. Diabetes Obes Metab. 2011;13(4):289-301.
Xie, W., & Du, L. (2011). Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. Diabetes, Obesity & Metabolism, 13(4), 289-301. https://doi.org/10.1111/j.1463-1326.2010.01336.x
Xie W, Du L. Diabetes Is an Inflammatory Disease: Evidence From Traditional Chinese Medicines. Diabetes Obes Metab. 2011;13(4):289-301. PubMed PMID: 21205111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. AU - Xie,W, AU - Du,L, PY - 2011/1/6/entrez PY - 2011/1/6/pubmed PY - 2011/6/18/medline SP - 289 EP - 301 JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab VL - 13 IS - 4 N2 - Diabetes is usually associated with inflammation. Inflammation contributes to the development of diabetes. Traditional Chinese medicines (TCM) play an important role in lowering blood glucose and controlling inflammation. Many studies show that TCM with hypoglycaemic effects, for example Radix Astragali, Radix Rehmanniae, Radix Trichosanthis, Panax Ginseng, Fructus Schisandrae, Radix Ophiopogonis, Rhizoma Anemarrhenae, Radix Puerariae, Fructus Lycii, Poria, Rhizoma Coptidis, Rhizoma Dioscoreae, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Semen Trigonellae, Momordica charantia, Allium sativum, Opuntia stricta, Aloe vera, Cortex Cinnamomi, Rhizoma Curcumae Longae, and so on, have nearly independent anti-inflammatory action. Antihyperglycaemic compounds, for example berberine, puerarin, quercetin, ferulic acid, astragaloside IV, curcumin, epigallocatechin gallate, resveratrol, tetrandrine, glycyrrhizin, emodin and baicalin, used in TCM also have anti-inflammatory effects. These studies suggest that TCM might exert hypoglycaemic effects that are partly mediated by the anti-inflammatory mechanisms. However, small amounts of TCM with potent anti-inflammatory action does not have any hypoglycaemic effect. This indirectly indicates that diabetes may be a low-grade inflammatory disease and potent regulation of inflammatory mediators may not be required. Studies of TCM add new evidences, which indicate that diabetes may be an inflammatory disease and slight or moderate inhibition of inflammation might be useful to prevent the development of diabetes. Through this review, we aim to develop more perspectives to indicate that diabetes may be an inflammatory disease and diverse TCM may share a common antidiabetic property: anti-inflammatory action. Further studies should focus on and validate inflammation-regulating targets of TCM that may be involved in inhibiting the development of diabetes. SN - 1463-1326 UR - https://www.unboundmedicine.com/medline/citation/21205111/Diabetes_is_an_inflammatory_disease:_evidence_from_traditional_Chinese_medicines_ L2 - https://doi.org/10.1111/j.1463-1326.2010.01336.x DB - PRIME DP - Unbound Medicine ER -