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Alterations in plasma amino acid levels in chronic pancreatitis.
JOP. 2011 Jan 05; 12(1):11-8.JOP

Abstract

CONTEXT

Dietary proteins and amino acids can modulate pancreatic function.

OBJECTIVE

Our aim was to estimate the levels of plasma amino acids in chronic pancreatitis patients and study their relationship with disease characteristics as well as exocrine and endocrine insufficiency.

PATIENTS

One hundred and seventy-five consecutive adult patients with chronic pancreatitis: 84 patients with alcoholic chronic pancreatitis and 91 patients with tropical chronic pancreatitis. One hundred and thirteen healthy controls were also studied.

DESIGN

Prospective study.

MAIN OUTCOME MEASURES

Disease characteristics and imaging features were recorded. Plasma-free amino acid levels were estimated using reverse-phase high-performance liquid chromatography. Polyclonal antibody ELISA was used to assess pancreatic fecal elastase-1.

RESULTS

The majority of the plasma free amino acid levels decreased in chronic pancreatitis patients whereas glutamate, glycine, proline and lysine were elevated as compared to the controls. Multivariate logistic regression analysis revealed that the decrease in branched chain amino acid concentration was significantly associated with the presence of diabetes and low fecal elastase-1. In addition, a significant positive correlation was observed between branched chain amino acids and pancreatic elastase-1 (rs=0.724, P<0.001).

CONCLUSION

Reductions of plasma amino acid levels are seen in chronic pancreatitis, particularly sulphur containing amino acids and branched chain amino acids. Selective amino acid deficiencies seem to correlate with exocrine and endocrine insufficiency.

Authors+Show Affiliations

Departments of Gastroenterology, Physiology and Biochemistry, Amrita Institute of Medical Sciences, Cochin, Kerala, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21206095

Citation

Girish, Banavara Narasimhamurthy, et al. "Alterations in Plasma Amino Acid Levels in Chronic Pancreatitis." JOP : Journal of the Pancreas, vol. 12, no. 1, 2011, pp. 11-8.
Girish BN, Rajesh G, Vaidyanathan K, et al. Alterations in plasma amino acid levels in chronic pancreatitis. JOP. 2011;12(1):11-8.
Girish, B. N., Rajesh, G., Vaidyanathan, K., & Balakrishnan, V. (2011). Alterations in plasma amino acid levels in chronic pancreatitis. JOP : Journal of the Pancreas, 12(1), 11-8.
Girish BN, et al. Alterations in Plasma Amino Acid Levels in Chronic Pancreatitis. JOP. 2011 Jan 5;12(1):11-8. PubMed PMID: 21206095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations in plasma amino acid levels in chronic pancreatitis. AU - Girish,Banavara Narasimhamurthy, AU - Rajesh,Gopalakrishna, AU - Vaidyanathan,Kannan, AU - Balakrishnan,Vallath, Y1 - 2011/01/05/ PY - 2011/1/6/entrez PY - 2011/1/6/pubmed PY - 2011/4/29/medline SP - 11 EP - 8 JF - JOP : Journal of the pancreas JO - JOP VL - 12 IS - 1 N2 - CONTEXT: Dietary proteins and amino acids can modulate pancreatic function. OBJECTIVE: Our aim was to estimate the levels of plasma amino acids in chronic pancreatitis patients and study their relationship with disease characteristics as well as exocrine and endocrine insufficiency. PATIENTS: One hundred and seventy-five consecutive adult patients with chronic pancreatitis: 84 patients with alcoholic chronic pancreatitis and 91 patients with tropical chronic pancreatitis. One hundred and thirteen healthy controls were also studied. DESIGN: Prospective study. MAIN OUTCOME MEASURES: Disease characteristics and imaging features were recorded. Plasma-free amino acid levels were estimated using reverse-phase high-performance liquid chromatography. Polyclonal antibody ELISA was used to assess pancreatic fecal elastase-1. RESULTS: The majority of the plasma free amino acid levels decreased in chronic pancreatitis patients whereas glutamate, glycine, proline and lysine were elevated as compared to the controls. Multivariate logistic regression analysis revealed that the decrease in branched chain amino acid concentration was significantly associated with the presence of diabetes and low fecal elastase-1. In addition, a significant positive correlation was observed between branched chain amino acids and pancreatic elastase-1 (rs=0.724, P<0.001). CONCLUSION: Reductions of plasma amino acid levels are seen in chronic pancreatitis, particularly sulphur containing amino acids and branched chain amino acids. Selective amino acid deficiencies seem to correlate with exocrine and endocrine insufficiency. SN - 1590-8577 UR - https://www.unboundmedicine.com/medline/citation/21206095/Alterations_in_plasma_amino_acid_levels_in_chronic_pancreatitis_ L2 - http://www.serena.unina.it/index.php/jop/article/view/3377/3657 DB - PRIME DP - Unbound Medicine ER -