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Association between Helicobacter pylori infection and pancreatic cancer. A cumulative meta-analysis.
JOP. 2011 Jan 05; 12(1):26-31.JOP

Abstract

CONTEXT

Infection with Helicobacter pylori (H. pylori) has been implicated in the etiopathogenesis of various malignant conditions. Notwithstanding, its etiological association with pancreatic cancer remains inconclusive. Studies focusing on the relationship between H. pylori infection and pancreatic cancer risk have yielded conflicting results.

OBJECTIVE

The aim of this study was to obtain a reliable estimate of the risk of H. pylori infection in causing pancreatic cancer, by performing a meta-analysis of the existing observational studies evaluating the association. METHODS/STATISTICS: Observational studies comparing the prevalence of H. pylori infection in patients with pancreatic cancer and healthy controls, conducted in adult populations and published in all languages, were identified through systematic search in the MEDLINE and EMBASE up to April 2010. H. pylori infection was confirmed by serological testing using an antigen-specific enzyme-linked immunosorbent assay. Pooled adjusted odds ratios (AOR) and associated 95% confidence intervals (CI) were obtained by using a DerSimonian and Laird random-effects model.

RESULTS

Six studies involving a total of 2,335 patients met our eligibility criteria. A significant association between H. pylori seropositivity and development of pancreatic cancer (AOR 1.38, 95% CI: 1.08-1.75; P=0.009) was seen. No significant association was seen on pooled analysis of the three studies assessing the relationship between cytotoxin-associated gene A (CagA) positivity and pancreatic cancer. A cumulative meta-analysis suggested a reducing, albeit statistically significant association as the evidence was accumulated.

CONCLUSIONS

The pooled data suggests an association between infection with H. pylori and the development of pancreatic cancer. Further research is needed to confirm our findings.

Authors+Show Affiliations

Department of Internal Medicine, University of Connecticut Medical Center, Farmington, CT, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

21206097

Citation

Trikudanathan, Guru, et al. "Association Between Helicobacter Pylori Infection and Pancreatic Cancer. a Cumulative Meta-analysis." JOP : Journal of the Pancreas, vol. 12, no. 1, 2011, pp. 26-31.
Trikudanathan G, Philip A, Dasanu CA, et al. Association between Helicobacter pylori infection and pancreatic cancer. A cumulative meta-analysis. JOP. 2011;12(1):26-31.
Trikudanathan, G., Philip, A., Dasanu, C. A., & Baker, W. L. (2011). Association between Helicobacter pylori infection and pancreatic cancer. A cumulative meta-analysis. JOP : Journal of the Pancreas, 12(1), 26-31.
Trikudanathan G, et al. Association Between Helicobacter Pylori Infection and Pancreatic Cancer. a Cumulative Meta-analysis. JOP. 2011 Jan 5;12(1):26-31. PubMed PMID: 21206097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Helicobacter pylori infection and pancreatic cancer. A cumulative meta-analysis. AU - Trikudanathan,Guru, AU - Philip,Aby, AU - Dasanu,Constantin A, AU - Baker,William L, Y1 - 2011/01/05/ PY - 2011/1/6/entrez PY - 2011/1/6/pubmed PY - 2011/4/29/medline SP - 26 EP - 31 JF - JOP : Journal of the pancreas JO - JOP VL - 12 IS - 1 N2 - CONTEXT: Infection with Helicobacter pylori (H. pylori) has been implicated in the etiopathogenesis of various malignant conditions. Notwithstanding, its etiological association with pancreatic cancer remains inconclusive. Studies focusing on the relationship between H. pylori infection and pancreatic cancer risk have yielded conflicting results. OBJECTIVE: The aim of this study was to obtain a reliable estimate of the risk of H. pylori infection in causing pancreatic cancer, by performing a meta-analysis of the existing observational studies evaluating the association. METHODS/STATISTICS: Observational studies comparing the prevalence of H. pylori infection in patients with pancreatic cancer and healthy controls, conducted in adult populations and published in all languages, were identified through systematic search in the MEDLINE and EMBASE up to April 2010. H. pylori infection was confirmed by serological testing using an antigen-specific enzyme-linked immunosorbent assay. Pooled adjusted odds ratios (AOR) and associated 95% confidence intervals (CI) were obtained by using a DerSimonian and Laird random-effects model. RESULTS: Six studies involving a total of 2,335 patients met our eligibility criteria. A significant association between H. pylori seropositivity and development of pancreatic cancer (AOR 1.38, 95% CI: 1.08-1.75; P=0.009) was seen. No significant association was seen on pooled analysis of the three studies assessing the relationship between cytotoxin-associated gene A (CagA) positivity and pancreatic cancer. A cumulative meta-analysis suggested a reducing, albeit statistically significant association as the evidence was accumulated. CONCLUSIONS: The pooled data suggests an association between infection with H. pylori and the development of pancreatic cancer. Further research is needed to confirm our findings. SN - 1590-8577 UR - https://www.unboundmedicine.com/medline/citation/21206097/Association_between_Helicobacter_pylori_infection_and_pancreatic_cancer__A_cumulative_meta_analysis_ L2 - http://www.serena.unina.it/index.php/jop/article/view/3379/3659 DB - PRIME DP - Unbound Medicine ER -