Tags

Type your tag names separated by a space and hit enter

Improvement of cutaneous sensitivity in diabetic peripheral neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate.
Rev Neurol Dis 2010; 7(4):132-9RN

Abstract

Studies of monotherapy with L-methylfolate, methylcobalamin, or pyridoxal 5'-phosphate suggest that these B vitamins may reverse both the symptoms and the pathophysiology of diabetic peripheral neuropathy (DPN). The efficacy of oral-combination L-methylfolate, 3 mg; methylcobalamin, 2 mg; and pyridoxal 5'-phosphate, 35 mg (LMF-MC-PP) in restoring cutaneous sensitivity in patients with type 2 diabetes with DPN was evaluated in 20 type 2 diabetic patients who were given LMF-MC-PP twice daily for 4 weeks and then once daily for an additional 48 weeks. Statistically significant improvement in 1-point (tactile) and 2-point (discriminatory) static testing at the right and left great toe and heel in the patients was observed in all 3 follow-up periods: 1) baseline to 6 months, 2) baseline to 1 year, and 3) 6 months to 1 year. The greatest improvement occurred between baseline and 1 year of treatment. Treatment with oral LMF-MC-PP appears to promote restoration of lost cutaneous sensation in DPN.

Authors+Show Affiliations

Carolina Musculoskeletal Institute, Aiken, SC, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21206429

Citation

Walker, Mackie J., et al. "Improvement of Cutaneous Sensitivity in Diabetic Peripheral Neuropathy With Combination L-methylfolate, Methylcobalamin, and Pyridoxal 5'-phosphate." Reviews in Neurological Diseases, vol. 7, no. 4, 2010, pp. 132-9.
Walker MJ, Morris LM, Cheng D. Improvement of cutaneous sensitivity in diabetic peripheral neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate. Rev Neurol Dis. 2010;7(4):132-9.
Walker, M. J., Morris, L. M., & Cheng, D. (2010). Improvement of cutaneous sensitivity in diabetic peripheral neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate. Reviews in Neurological Diseases, 7(4), pp. 132-9.
Walker MJ, Morris LM, Cheng D. Improvement of Cutaneous Sensitivity in Diabetic Peripheral Neuropathy With Combination L-methylfolate, Methylcobalamin, and Pyridoxal 5'-phosphate. Rev Neurol Dis. 2010;7(4):132-9. PubMed PMID: 21206429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement of cutaneous sensitivity in diabetic peripheral neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate. AU - Walker,Mackie J,Jr AU - Morris,Lauren M, AU - Cheng,Dunlei, PY - 2011/1/6/entrez PY - 2011/1/6/pubmed PY - 2011/10/1/medline SP - 132 EP - 9 JF - Reviews in neurological diseases JO - Rev Neurol Dis VL - 7 IS - 4 N2 - Studies of monotherapy with L-methylfolate, methylcobalamin, or pyridoxal 5'-phosphate suggest that these B vitamins may reverse both the symptoms and the pathophysiology of diabetic peripheral neuropathy (DPN). The efficacy of oral-combination L-methylfolate, 3 mg; methylcobalamin, 2 mg; and pyridoxal 5'-phosphate, 35 mg (LMF-MC-PP) in restoring cutaneous sensitivity in patients with type 2 diabetes with DPN was evaluated in 20 type 2 diabetic patients who were given LMF-MC-PP twice daily for 4 weeks and then once daily for an additional 48 weeks. Statistically significant improvement in 1-point (tactile) and 2-point (discriminatory) static testing at the right and left great toe and heel in the patients was observed in all 3 follow-up periods: 1) baseline to 6 months, 2) baseline to 1 year, and 3) 6 months to 1 year. The greatest improvement occurred between baseline and 1 year of treatment. Treatment with oral LMF-MC-PP appears to promote restoration of lost cutaneous sensation in DPN. SN - 1949-4378 UR - https://www.unboundmedicine.com/medline/citation/21206429/Improvement_of_cutaneous_sensitivity_in_diabetic_peripheral_neuropathy_with_combination_L_methylfolate_methylcobalamin_and_pyridoxal_5'_phosphate_ L2 - https://medlineplus.gov/diabeticnerveproblems.html DB - PRIME DP - Unbound Medicine ER -