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Immunohistochemical analysis of claudin expression in pancreatic cystic tumors.
Oncol Rep. 2011 Apr; 25(4):971-8.OR

Abstract

Aberrant expression of the claudin family of proteins has been reported in many human cancers, including pancreatic ductal carcinoma. Intraductal papillary mucinous neoplasms of the pancreas (IPMN) and mucinous cystic neoplasms (MCN) are considered precancerous lesions that are able to progress towards pancreatic ductal adenocarcinoma. We analyzed the expression of several claudin family members using surgical IPMN and MCN specimens to clarify the relationships between claudin expression and clinicopathological features. Twenty-nine and 25 consecutive cases of IPMN and MCN were selected and the expression of claudin-2, -4 and -18 was analyzed by immunohistochemistry. In addition, IPMN and MCN histological grade as well as IPMN subtypes were analyzed in relation to claudin expression. The 29 cases of IPMN comprised of 3 (10.3%) adenomas, 18 (62.1%) borderline malignancies and 8 (27.6%) carcinomas. The 25 cases of MCN comprised of 13 (52%) adenomas, 5 (20%) borderline malignancies and 7 (28%) carcinomas. Claudin-2, -4 and -18 showed strong expression both in IPMN and MCN, with the exception of claudin-4 in MCN. The expression grades of claudin-2 in both IPMN and MCN became weaker with increased histological grade. On the other hand, the expression grades of claudin-4 and -18 became stronger with increased histological grade in both IPMN and MCN. With regard to histological subtype, claudin-4 expression was the strongest in pancreatobiliary type IPMN, and claudin-18 expression was the strongest in gastric type IPMN. The distinct expression patterns of claudin-2, -4 and -18 suggest that claudins may serve as useful molecular markers for tumor differentiation and progression in IPMN and MCN.

Authors+Show Affiliations

Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21206985

Citation

Lee, Jin Ha, et al. "Immunohistochemical Analysis of Claudin Expression in Pancreatic Cystic Tumors." Oncology Reports, vol. 25, no. 4, 2011, pp. 971-8.
Lee JH, Kim KS, Kim TJ, et al. Immunohistochemical analysis of claudin expression in pancreatic cystic tumors. Oncol Rep. 2011;25(4):971-8.
Lee, J. H., Kim, K. S., Kim, T. J., Hong, S. P., Song, S. Y., Chung, J. B., & Park, S. W. (2011). Immunohistochemical analysis of claudin expression in pancreatic cystic tumors. Oncology Reports, 25(4), 971-8. https://doi.org/10.3892/or.2011.1132
Lee JH, et al. Immunohistochemical Analysis of Claudin Expression in Pancreatic Cystic Tumors. Oncol Rep. 2011;25(4):971-8. PubMed PMID: 21206985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical analysis of claudin expression in pancreatic cystic tumors. AU - Lee,Jin Ha, AU - Kim,Kyung Sik, AU - Kim,Tae-Jung, AU - Hong,Sung Pil, AU - Song,Si Young, AU - Chung,Jae Bock, AU - Park,Seung Woo, Y1 - 2011/01/03/ PY - 2010/09/09/received PY - 2010/12/03/accepted PY - 2011/1/6/entrez PY - 2011/1/6/pubmed PY - 2011/7/16/medline SP - 971 EP - 8 JF - Oncology reports JO - Oncol Rep VL - 25 IS - 4 N2 - Aberrant expression of the claudin family of proteins has been reported in many human cancers, including pancreatic ductal carcinoma. Intraductal papillary mucinous neoplasms of the pancreas (IPMN) and mucinous cystic neoplasms (MCN) are considered precancerous lesions that are able to progress towards pancreatic ductal adenocarcinoma. We analyzed the expression of several claudin family members using surgical IPMN and MCN specimens to clarify the relationships between claudin expression and clinicopathological features. Twenty-nine and 25 consecutive cases of IPMN and MCN were selected and the expression of claudin-2, -4 and -18 was analyzed by immunohistochemistry. In addition, IPMN and MCN histological grade as well as IPMN subtypes were analyzed in relation to claudin expression. The 29 cases of IPMN comprised of 3 (10.3%) adenomas, 18 (62.1%) borderline malignancies and 8 (27.6%) carcinomas. The 25 cases of MCN comprised of 13 (52%) adenomas, 5 (20%) borderline malignancies and 7 (28%) carcinomas. Claudin-2, -4 and -18 showed strong expression both in IPMN and MCN, with the exception of claudin-4 in MCN. The expression grades of claudin-2 in both IPMN and MCN became weaker with increased histological grade. On the other hand, the expression grades of claudin-4 and -18 became stronger with increased histological grade in both IPMN and MCN. With regard to histological subtype, claudin-4 expression was the strongest in pancreatobiliary type IPMN, and claudin-18 expression was the strongest in gastric type IPMN. The distinct expression patterns of claudin-2, -4 and -18 suggest that claudins may serve as useful molecular markers for tumor differentiation and progression in IPMN and MCN. SN - 1791-2431 UR - https://www.unboundmedicine.com/medline/citation/21206985/Immunohistochemical_analysis_of_claudin_expression_in_pancreatic_cystic_tumors_ L2 - http://www.spandidos-publications.com/or/25/4/971 DB - PRIME DP - Unbound Medicine ER -