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Patient age and preoperative breast MRI in women with breast cancer: biopsy and surgical implications.
Ann Surg Oncol. 2011 Jun; 18(6):1678-83.AS

Abstract

BACKGROUND

The influence of patient age on multidisciplinary treatment planning after preoperative breast magnetic resonance imaging (MRI) and its influence on the surgical decision-making process are unclear.

METHODS

We performed a retrospective review of 710 women with breast cancer who underwent preoperative MRI at our institution between January 2003 and December 2008. Analysis by patient age included the number of additional ipsilateral MRI findings, the number of biopsies recommended/performed, the number of additional cancers found, and the percentage of patients undergoing mastectomy.

RESULTS

Of the 710 patients, 343 (48%) had additional ipsilateral MRI findings. After stratifying by age, the incidence of additional ipsilateral findings differed between decades (P = 0.004). However, fewer biopsies were recommended in older patients (P = 0.043). The number of women pursuing preoperative needle biopsy increased with age (P = 0.0018), while the incidence of a second focus of breast cancer did not change with age (P = 0.07). The mastectomy rate decreased from 65% in women younger than 50 to 40% in women older than 70 (P < 0.001).

CONCLUSIONS

In the setting of newly diagnosed breast cancer, the value of MRI is not influenced by patient age, with at least 40% of women in all age groups having additional findings on MRI. Insisting on preoperative needle biopsy of additional findings may decrease mastectomy rates. Further study is needed to determine the reasons for the increased percentage of mastectomies in younger women.

Authors+Show Affiliations

Department of Surgery, Mayo Clinic Florida, Jacksonville, FL, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21207171

Citation

Adkisson, Cameron D., et al. "Patient Age and Preoperative Breast MRI in Women With Breast Cancer: Biopsy and Surgical Implications." Annals of Surgical Oncology, vol. 18, no. 6, 2011, pp. 1678-83.
Adkisson CD, Vallow LA, Kowalchik K, et al. Patient age and preoperative breast MRI in women with breast cancer: biopsy and surgical implications. Ann Surg Oncol. 2011;18(6):1678-83.
Adkisson, C. D., Vallow, L. A., Kowalchik, K., McNeil, R., Hines, S., Deperi, E., Moreno, A., Roy, V., Perez, E. A., & McLaughlin, S. A. (2011). Patient age and preoperative breast MRI in women with breast cancer: biopsy and surgical implications. Annals of Surgical Oncology, 18(6), 1678-83. https://doi.org/10.1245/s10434-010-1491-4
Adkisson CD, et al. Patient Age and Preoperative Breast MRI in Women With Breast Cancer: Biopsy and Surgical Implications. Ann Surg Oncol. 2011;18(6):1678-83. PubMed PMID: 21207171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patient age and preoperative breast MRI in women with breast cancer: biopsy and surgical implications. AU - Adkisson,Cameron D, AU - Vallow,Laura A, AU - Kowalchik,Kristin, AU - McNeil,Rebecca, AU - Hines,Stephanie, AU - Deperi,Elizabeth, AU - Moreno,Alvaro, AU - Roy,Vivek, AU - Perez,Edith A, AU - McLaughlin,Sarah A, Y1 - 2011/01/05/ PY - 2010/06/14/received PY - 2011/1/6/entrez PY - 2011/1/6/pubmed PY - 2011/8/31/medline SP - 1678 EP - 83 JF - Annals of surgical oncology JO - Ann Surg Oncol VL - 18 IS - 6 N2 - BACKGROUND: The influence of patient age on multidisciplinary treatment planning after preoperative breast magnetic resonance imaging (MRI) and its influence on the surgical decision-making process are unclear. METHODS: We performed a retrospective review of 710 women with breast cancer who underwent preoperative MRI at our institution between January 2003 and December 2008. Analysis by patient age included the number of additional ipsilateral MRI findings, the number of biopsies recommended/performed, the number of additional cancers found, and the percentage of patients undergoing mastectomy. RESULTS: Of the 710 patients, 343 (48%) had additional ipsilateral MRI findings. After stratifying by age, the incidence of additional ipsilateral findings differed between decades (P = 0.004). However, fewer biopsies were recommended in older patients (P = 0.043). The number of women pursuing preoperative needle biopsy increased with age (P = 0.0018), while the incidence of a second focus of breast cancer did not change with age (P = 0.07). The mastectomy rate decreased from 65% in women younger than 50 to 40% in women older than 70 (P < 0.001). CONCLUSIONS: In the setting of newly diagnosed breast cancer, the value of MRI is not influenced by patient age, with at least 40% of women in all age groups having additional findings on MRI. Insisting on preoperative needle biopsy of additional findings may decrease mastectomy rates. Further study is needed to determine the reasons for the increased percentage of mastectomies in younger women. SN - 1534-4681 UR - https://www.unboundmedicine.com/medline/citation/21207171/Patient_age_and_preoperative_breast_MRI_in_women_with_breast_cancer:_biopsy_and_surgical_implications_ L2 - https://dx.doi.org/10.1245/s10434-010-1491-4 DB - PRIME DP - Unbound Medicine ER -