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Mammography-guided stereotactic fine-needle aspiration cytology of nonpalpable breast lesions: prospective comparison with surgical biopsy results.
AJR Am J Roentgenol. 1990 Nov; 155(5):977-81.AA

Abstract

We assessed the usefulness of fine-needle aspiration cytology (FNAC) in evaluating nonpalpable breast abnormalities by prospectively performing stereotactic mammography-guided FNAC on 100 women undergoing surgical excisional biopsy. Mammographic and cytologic diagnoses, on a scale of 1 (benign) to 4 (malignant), were assigned for each case and compared with the surgical pathologic diagnosis. Sensitivity and specificity were examined at different diagnostic cutoff points for regarding a mammographic or cytologic diagnosis as positive or negative. Of the 100 breast biopsy specimens, 70 were benign and 30 were malignant. For both mammography and FNAC, the optimal diagnostic cutoff point was between diagnosis 2 (mammography, probably benign; cytology, atypical) and 3 (mammography and cytology both suspicious for malignancy). At this cutoff point, FNAC had a sensitivity of 0.77 and specificity of 1.00, vs 0.73 sensitivity and 0.79 specificity for mammography. Pearson coefficient analysis revealed significant correlations between both mammographic and FNAC diagnoses and surgical pathology (p less than .001 for both). Our results suggest that use of mammography-guided FNAC may reduce the number of breast biopsies performed for benign lesions.

Authors+Show Affiliations

Department of Radiology, University of Arizona University Medical Center, Tucson 85724.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2120967

Citation

Fajardo, L L., et al. "Mammography-guided Stereotactic Fine-needle Aspiration Cytology of Nonpalpable Breast Lesions: Prospective Comparison With Surgical Biopsy Results." AJR. American Journal of Roentgenology, vol. 155, no. 5, 1990, pp. 977-81.
Fajardo LL, Davis JR, Wiens JL, et al. Mammography-guided stereotactic fine-needle aspiration cytology of nonpalpable breast lesions: prospective comparison with surgical biopsy results. AJR Am J Roentgenol. 1990;155(5):977-81.
Fajardo, L. L., Davis, J. R., Wiens, J. L., & Trego, D. C. (1990). Mammography-guided stereotactic fine-needle aspiration cytology of nonpalpable breast lesions: prospective comparison with surgical biopsy results. AJR. American Journal of Roentgenology, 155(5), 977-81.
Fajardo LL, et al. Mammography-guided Stereotactic Fine-needle Aspiration Cytology of Nonpalpable Breast Lesions: Prospective Comparison With Surgical Biopsy Results. AJR Am J Roentgenol. 1990;155(5):977-81. PubMed PMID: 2120967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mammography-guided stereotactic fine-needle aspiration cytology of nonpalpable breast lesions: prospective comparison with surgical biopsy results. AU - Fajardo,L L, AU - Davis,J R, AU - Wiens,J L, AU - Trego,D C, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 977 EP - 81 JF - AJR. American journal of roentgenology JO - AJR Am J Roentgenol VL - 155 IS - 5 N2 - We assessed the usefulness of fine-needle aspiration cytology (FNAC) in evaluating nonpalpable breast abnormalities by prospectively performing stereotactic mammography-guided FNAC on 100 women undergoing surgical excisional biopsy. Mammographic and cytologic diagnoses, on a scale of 1 (benign) to 4 (malignant), were assigned for each case and compared with the surgical pathologic diagnosis. Sensitivity and specificity were examined at different diagnostic cutoff points for regarding a mammographic or cytologic diagnosis as positive or negative. Of the 100 breast biopsy specimens, 70 were benign and 30 were malignant. For both mammography and FNAC, the optimal diagnostic cutoff point was between diagnosis 2 (mammography, probably benign; cytology, atypical) and 3 (mammography and cytology both suspicious for malignancy). At this cutoff point, FNAC had a sensitivity of 0.77 and specificity of 1.00, vs 0.73 sensitivity and 0.79 specificity for mammography. Pearson coefficient analysis revealed significant correlations between both mammographic and FNAC diagnoses and surgical pathology (p less than .001 for both). Our results suggest that use of mammography-guided FNAC may reduce the number of breast biopsies performed for benign lesions. SN - 0361-803X UR - https://www.unboundmedicine.com/medline/citation/2120967/Mammography_guided_stereotactic_fine_needle_aspiration_cytology_of_nonpalpable_breast_lesions:_prospective_comparison_with_surgical_biopsy_results_ L2 - https://www.ajronline.org/doi/10.2214/ajr.155.5.2120967 DB - PRIME DP - Unbound Medicine ER -