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Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence.
BMC Neurosci 2011; 12:2BN

Abstract

BACKGROUND

Transcranial direct current stimulation (tDCS) is a technique that can systematically modify behaviour by inducing changes in the underlying brain function. In order to better understand the neuromodulatory effect of tDCS, the present study examined the impact of tDCS on performance in a working memory (WM) task and its underlying neural activity. In two experimental sessions, participants performed a letter two-back WM task after sham and either anodal or cathodal tDCS over the left dorsolateral prefrontal cortex (DLPFC).

RESULTS

Results showed that tDCS modulated WM performance by altering the underlying oscillatory brain activity in a polarity-specific way. We observed an increase in WM performance and amplified oscillatory power in the theta and alpha bands after anodal tDCS whereas cathodal tDCS interfered with WM performance and decreased oscillatory power in the theta and alpha bands under posterior electrode sides.

CONCLUSIONS

The present study demonstrates that tDCS can alter WM performance by modulating the underlying neural oscillations. This result can be considered an important step towards a better understanding of the mechanisms involved in tDCS-induced modulations of WM performance, which is of particular importance, given the proposal to use electrical brain stimulation for the therapeutic treatment of memory deficits in clinical settings.

Authors+Show Affiliations

Department of Neurology, Otto v, Guericke University Magdeburg, Germany. tino.zaehle@DZNE.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21211016

Citation

Zaehle, Tino, et al. "Transcranial Direct Current Stimulation of the Prefrontal Cortex Modulates Working Memory Performance: Combined Behavioural and Electrophysiological Evidence." BMC Neuroscience, vol. 12, 2011, p. 2.
Zaehle T, Sandmann P, Thorne JD, et al. Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence. BMC Neurosci. 2011;12:2.
Zaehle, T., Sandmann, P., Thorne, J. D., Jäncke, L., & Herrmann, C. S. (2011). Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence. BMC Neuroscience, 12, p. 2. doi:10.1186/1471-2202-12-2.
Zaehle T, et al. Transcranial Direct Current Stimulation of the Prefrontal Cortex Modulates Working Memory Performance: Combined Behavioural and Electrophysiological Evidence. BMC Neurosci. 2011 Jan 6;12:2. PubMed PMID: 21211016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence. AU - Zaehle,Tino, AU - Sandmann,Pascale, AU - Thorne,Jeremy D, AU - Jäncke,Lutz, AU - Herrmann,Christoph S, Y1 - 2011/01/06/ PY - 2010/10/01/received PY - 2011/01/06/accepted PY - 2011/1/8/entrez PY - 2011/1/8/pubmed PY - 2011/11/15/medline SP - 2 EP - 2 JF - BMC neuroscience JO - BMC Neurosci VL - 12 N2 - BACKGROUND: Transcranial direct current stimulation (tDCS) is a technique that can systematically modify behaviour by inducing changes in the underlying brain function. In order to better understand the neuromodulatory effect of tDCS, the present study examined the impact of tDCS on performance in a working memory (WM) task and its underlying neural activity. In two experimental sessions, participants performed a letter two-back WM task after sham and either anodal or cathodal tDCS over the left dorsolateral prefrontal cortex (DLPFC). RESULTS: Results showed that tDCS modulated WM performance by altering the underlying oscillatory brain activity in a polarity-specific way. We observed an increase in WM performance and amplified oscillatory power in the theta and alpha bands after anodal tDCS whereas cathodal tDCS interfered with WM performance and decreased oscillatory power in the theta and alpha bands under posterior electrode sides. CONCLUSIONS: The present study demonstrates that tDCS can alter WM performance by modulating the underlying neural oscillations. This result can be considered an important step towards a better understanding of the mechanisms involved in tDCS-induced modulations of WM performance, which is of particular importance, given the proposal to use electrical brain stimulation for the therapeutic treatment of memory deficits in clinical settings. SN - 1471-2202 UR - https://www.unboundmedicine.com/medline/citation/21211016/Transcranial_direct_current_stimulation_of_the_prefrontal_cortex_modulates_working_memory_performance:_combined_behavioural_and_electrophysiological_evidence_ L2 - https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-12-2 DB - PRIME DP - Unbound Medicine ER -