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A species-specific approach to the use of non-antimony treatments for cutaneous leishmaniasis.
Am J Trop Med Hyg. 2011 Jan; 84(1):109-17.AJ

Abstract

We used a species-specific approach to treat 10 patients with cutaneous leishmaniasis diagnosed using polymerase chain reaction. Non-antimony treatments (oral miltefosine, ketoconazole, and liposomal amphotericin B) were chosen as an alternative to pentavalent antimony drugs based on likely or proven drug efficacy against the infecting species. Leishmania Viannia panamensis was diagnosed in three patients and treated successfully with oral ketoconazole. Miltefosine treatment cured two patients with L. infantum chagasi. A wide variety of Leishmania responded to liposomal amphotericin B administered for 5-7 days. Three patients with L. V. braziliensis, one patient with L. tropica, and two patients with L. infantum chagasi were treated successfully. One person with L. V. braziliensis healed slowly because of a resistant bacterial superinfection, and a second patient with L. infantum chagasi relapsed and was retreated with miltefosine. These drugs were reasonably well-tolerated. In this limited case series, alternative non-antimony-based regimens were convenient, safe, and effective.

Authors+Show Affiliations

Clinical Parasitology Unit and Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. ramanathanr@niaid.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

21212212

Citation

Ramanathan, Roshan, et al. "A Species-specific Approach to the Use of Non-antimony Treatments for Cutaneous Leishmaniasis." The American Journal of Tropical Medicine and Hygiene, vol. 84, no. 1, 2011, pp. 109-17.
Ramanathan R, Talaat KR, Fedorko DP, et al. A species-specific approach to the use of non-antimony treatments for cutaneous leishmaniasis. Am J Trop Med Hyg. 2011;84(1):109-17.
Ramanathan, R., Talaat, K. R., Fedorko, D. P., Mahanty, S., & Nash, T. E. (2011). A species-specific approach to the use of non-antimony treatments for cutaneous leishmaniasis. The American Journal of Tropical Medicine and Hygiene, 84(1), 109-17. https://doi.org/10.4269/ajtmh.2011.10-0437
Ramanathan R, et al. A Species-specific Approach to the Use of Non-antimony Treatments for Cutaneous Leishmaniasis. Am J Trop Med Hyg. 2011;84(1):109-17. PubMed PMID: 21212212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A species-specific approach to the use of non-antimony treatments for cutaneous leishmaniasis. AU - Ramanathan,Roshan, AU - Talaat,Kawsar R, AU - Fedorko,Daniel P, AU - Mahanty,Siddhartha, AU - Nash,Theodore E, PY - 2011/1/8/entrez PY - 2011/1/8/pubmed PY - 2011/2/23/medline SP - 109 EP - 17 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 84 IS - 1 N2 - We used a species-specific approach to treat 10 patients with cutaneous leishmaniasis diagnosed using polymerase chain reaction. Non-antimony treatments (oral miltefosine, ketoconazole, and liposomal amphotericin B) were chosen as an alternative to pentavalent antimony drugs based on likely or proven drug efficacy against the infecting species. Leishmania Viannia panamensis was diagnosed in three patients and treated successfully with oral ketoconazole. Miltefosine treatment cured two patients with L. infantum chagasi. A wide variety of Leishmania responded to liposomal amphotericin B administered for 5-7 days. Three patients with L. V. braziliensis, one patient with L. tropica, and two patients with L. infantum chagasi were treated successfully. One person with L. V. braziliensis healed slowly because of a resistant bacterial superinfection, and a second patient with L. infantum chagasi relapsed and was retreated with miltefosine. These drugs were reasonably well-tolerated. In this limited case series, alternative non-antimony-based regimens were convenient, safe, and effective. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/21212212/A_species_specific_approach_to_the_use_of_non_antimony_treatments_for_cutaneous_leishmaniasis_ L2 - https://ajtmh.org/doi/10.4269/ajtmh.2011.10-0437 DB - PRIME DP - Unbound Medicine ER -