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Lipid peroxidation and antioxidant defense enzymes in Clarias gariepinus as useful biomarkers for monitoring exposure to polycyclic aromatic hydrocarbons.
Environ Monit Assess. 2011 Nov; 182(1-4):205-13.EM

Abstract

The toxicological evaluations of crude oil, xylene, toluene and benzene were carried out against juvenile stages of Clarias gariepinus. On the basis of LC(50) value, benzene (0.017 ml/l) was found to be the most toxic followed by xylene (0.086 ml/l), toluene (0.398 ml/l) and crude oil (2.219 ml/l) was the least toxic. The results of the lipid peroxidation assay showed that the level of malonaldehyde (MDA) in liver and gills of fish exposed to all the test chemicals increased significantly (P < 0.05) when compared to control. Measurement of activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) in liver and gill of fishes exposed to sublethal concentration of the test chemicals over a 28-day period was found to decrease significantly (P < 0.05) when compared to control. The observed reduction in the activities of antioxidant defense enzymes such as SOD, CAT and GST in conjunction with an increase in MDA levels in the gill and liver tissues of test animals exposed to aromatic hydrocarbon compounds were recommended as a good battery of biomarkers for early detection of pollution during biomonitoring programmes.

Authors+Show Affiliations

Department of Zoology, Ecotoxicology Unit, Faculty of Science, University of Lagos, Akoka, Lagos, Nigeria. bayotitoloju@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21213039

Citation

Otitoloju, Adebayo, and Oluwatoyin Olagoke. "Lipid Peroxidation and Antioxidant Defense Enzymes in Clarias Gariepinus as Useful Biomarkers for Monitoring Exposure to Polycyclic Aromatic Hydrocarbons." Environmental Monitoring and Assessment, vol. 182, no. 1-4, 2011, pp. 205-13.
Otitoloju A, Olagoke O. Lipid peroxidation and antioxidant defense enzymes in Clarias gariepinus as useful biomarkers for monitoring exposure to polycyclic aromatic hydrocarbons. Environ Monit Assess. 2011;182(1-4):205-13.
Otitoloju, A., & Olagoke, O. (2011). Lipid peroxidation and antioxidant defense enzymes in Clarias gariepinus as useful biomarkers for monitoring exposure to polycyclic aromatic hydrocarbons. Environmental Monitoring and Assessment, 182(1-4), 205-13. https://doi.org/10.1007/s10661-010-1870-0
Otitoloju A, Olagoke O. Lipid Peroxidation and Antioxidant Defense Enzymes in Clarias Gariepinus as Useful Biomarkers for Monitoring Exposure to Polycyclic Aromatic Hydrocarbons. Environ Monit Assess. 2011;182(1-4):205-13. PubMed PMID: 21213039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid peroxidation and antioxidant defense enzymes in Clarias gariepinus as useful biomarkers for monitoring exposure to polycyclic aromatic hydrocarbons. AU - Otitoloju,Adebayo, AU - Olagoke,Oluwatoyin, Y1 - 2011/01/07/ PY - 2010/05/12/received PY - 2010/12/22/accepted PY - 2011/1/8/entrez PY - 2011/1/8/pubmed PY - 2012/1/4/medline SP - 205 EP - 13 JF - Environmental monitoring and assessment JO - Environ Monit Assess VL - 182 IS - 1-4 N2 - The toxicological evaluations of crude oil, xylene, toluene and benzene were carried out against juvenile stages of Clarias gariepinus. On the basis of LC(50) value, benzene (0.017 ml/l) was found to be the most toxic followed by xylene (0.086 ml/l), toluene (0.398 ml/l) and crude oil (2.219 ml/l) was the least toxic. The results of the lipid peroxidation assay showed that the level of malonaldehyde (MDA) in liver and gills of fish exposed to all the test chemicals increased significantly (P < 0.05) when compared to control. Measurement of activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) in liver and gill of fishes exposed to sublethal concentration of the test chemicals over a 28-day period was found to decrease significantly (P < 0.05) when compared to control. The observed reduction in the activities of antioxidant defense enzymes such as SOD, CAT and GST in conjunction with an increase in MDA levels in the gill and liver tissues of test animals exposed to aromatic hydrocarbon compounds were recommended as a good battery of biomarkers for early detection of pollution during biomonitoring programmes. SN - 1573-2959 UR - https://www.unboundmedicine.com/medline/citation/21213039/Lipid_peroxidation_and_antioxidant_defense_enzymes_in_Clarias_gariepinus_as_useful_biomarkers_for_monitoring_exposure_to_polycyclic_aromatic_hydrocarbons_ L2 - https://doi.org/10.1007/s10661-010-1870-0 DB - PRIME DP - Unbound Medicine ER -