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In vitro anti-herpes simplex virus activity of 1,2,4,6-tetra-O-galloyl-β-D-glucose from Phyllanthus emblica L. (Euphorbiaceae).
Phytother Res. 2011 Jul; 25(7):975-82.PR

Abstract

In this study, 1,2,4,6-tetra-O-galloyl-β-D-glucose (1246TGG), a polyphenolic compound isolated from traditional Chinese medicine Phyllanthus emblica L. (Euphorbiaceae), was found to inhibit herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infection at different magnitudes of activity in vitro. Further studies revealed that 1246TGG directly inactivated HSV-1 particles, leading to the failure of early infection, including viral attachment and penetration. 1246TGG also suppressed the intracellular growth of HSV-1 within a long period post-infection (from 0 h p.i. to 12 h p.i.), while it might exert an antiviral effect mainly before 3 h p.i. It inhibited HSV-1 E and L gene expressions as well as viral DNA replication but did not affect the RNA synthesis of IE gene in our study. Also, in the presence of 1246TGG, the synthesis of viral protein was reduced. Taken together, it was suggested that 1246TGG might exert anti-HSV activity both by inactivating extracellular viral particles and by inhibiting viral biosynthesis in host cells. These results warrant further studies on the antiviral mechanisms of 1246TGG and suggest that it might be a candidate for HSV therapy.

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Authors+Show Affiliations

Xiang Y
Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, PR China.
Pei Y
No affiliation info available
Qu C
No affiliation info available
Lai Z
No affiliation info available
Ren Z
No affiliation info available
Yang K
No affiliation info available
Xiong S
No affiliation info available
Zhang Y
No affiliation info available
Yang C
No affiliation info available
Wang D
No affiliation info available
Liu Q
No affiliation info available
Kitazato K
No affiliation info available
Wang Y
No affiliation info available

MeSH

AnimalsAntiviral AgentsChlorocebus aethiopsDNA, ViralGallic AcidHerpesvirus 1, HumanHerpesvirus 2, HumanMonosaccharidesPhyllanthus emblicaVero CellsViral ProteinsVirus Replication

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21213355

Citation

Xiang, Yangfei, et al. "In Vitro Anti-herpes Simplex Virus Activity of 1,2,4,6-tetra-O-galloyl-β-D-glucose From Phyllanthus Emblica L. (Euphorbiaceae)." Phytotherapy Research : PTR, vol. 25, no. 7, 2011, pp. 975-82.
Xiang Y, Pei Y, Qu C, et al. In vitro anti-herpes simplex virus activity of 1,2,4,6-tetra-O-galloyl-β-D-glucose from Phyllanthus emblica L. (Euphorbiaceae). Phytother Res. 2011;25(7):975-82.
Xiang, Y., Pei, Y., Qu, C., Lai, Z., Ren, Z., Yang, K., Xiong, S., Zhang, Y., Yang, C., Wang, D., Liu, Q., Kitazato, K., & Wang, Y. (2011). In vitro anti-herpes simplex virus activity of 1,2,4,6-tetra-O-galloyl-β-D-glucose from Phyllanthus emblica L. (Euphorbiaceae). Phytotherapy Research : PTR, 25(7), 975-82. https://doi.org/10.1002/ptr.3368
Xiang Y, et al. In Vitro Anti-herpes Simplex Virus Activity of 1,2,4,6-tetra-O-galloyl-β-D-glucose From Phyllanthus Emblica L. (Euphorbiaceae). Phytother Res. 2011;25(7):975-82. PubMed PMID: 21213355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro anti-herpes simplex virus activity of 1,2,4,6-tetra-O-galloyl-β-D-glucose from Phyllanthus emblica L. (Euphorbiaceae). AU - Xiang,Yangfei, AU - Pei,Ying, AU - Qu,Chang, AU - Lai,Zhicai, AU - Ren,Zhe, AU - Yang,Ke, AU - Xiong,Sheng, AU - Zhang,Yingjun, AU - Yang,Chongren, AU - Wang,Dong, AU - Liu,Qing, AU - Kitazato,Kaio, AU - Wang,Yifei, PY - 2011/1/8/entrez PY - 2011/1/8/pubmed PY - 2012/10/17/medline SP - 975 EP - 82 JF - Phytotherapy research : PTR JO - Phytother Res VL - 25 IS - 7 N2 - In this study, 1,2,4,6-tetra-O-galloyl-β-D-glucose (1246TGG), a polyphenolic compound isolated from traditional Chinese medicine Phyllanthus emblica L. (Euphorbiaceae), was found to inhibit herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infection at different magnitudes of activity in vitro. Further studies revealed that 1246TGG directly inactivated HSV-1 particles, leading to the failure of early infection, including viral attachment and penetration. 1246TGG also suppressed the intracellular growth of HSV-1 within a long period post-infection (from 0 h p.i. to 12 h p.i.), while it might exert an antiviral effect mainly before 3 h p.i. It inhibited HSV-1 E and L gene expressions as well as viral DNA replication but did not affect the RNA synthesis of IE gene in our study. Also, in the presence of 1246TGG, the synthesis of viral protein was reduced. Taken together, it was suggested that 1246TGG might exert anti-HSV activity both by inactivating extracellular viral particles and by inhibiting viral biosynthesis in host cells. These results warrant further studies on the antiviral mechanisms of 1246TGG and suggest that it might be a candidate for HSV therapy. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/21213355/In_vitro_anti_herpes_simplex_virus_activity_of_1246_tetra_O_galloyl_β_D_glucose_from_Phyllanthus_emblica_L___Euphorbiaceae__ L2 - https://doi.org/10.1002/ptr.3368 DB - PRIME DP - Unbound Medicine ER -