Tags

Type your tag names separated by a space and hit enter

Immunogenicity and safety of a combined diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine (DTaP-IPV) compared to separate administration of standalone DTaP and IPV vaccines: a randomized, controlled study in infants in the Republic of Korea.
Vaccine. 2011 Feb 11; 29(8):1551-7.V

Abstract

This randomized trial enrolled 442 infants in the Republic of Korea to assess the immunogenicity and safety of a combined diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine (DTaP-IPV; Tetraxim™) for primary vaccination at 2, 4 and 6 months of age compared with DTaP and IPV vaccines given separately. Immunogenicity was high in both groups; seroprotection and seroconversion rates of the combined vaccine (Group A) were non-inferior to the control vaccines (Group B). All subjects were seroprotected against poliovirus types 1, 2 and 3 (≥ 81/dil) and anti-diphtheria (≥ 0.01 IU/mL); 99.0% were seroprotected against tetanus (≥ 0.1 IU/mL). At least 93.6% had anti-diphtheria antibody titers ≥ 0.1 IU/mL. Anti-pertussis toxoid (PT) and anti-filamentous haemagglutinin (FHA) seroconversion (≥ 4-fold increase in antibody titer) rates were 96.6% and 94.4% for Group A, 92.2% and 78.4% for Group B. Most solicited reactions occurred within 4 days of vaccination, resolved within 3 days and were mild. Severe solicited reactions occurred after ≤ 0.5% of doses in Group A and ≤ 0.9% in Group B. No withdrawals occurred because of adverse events. The DTaP-IPV combined vaccine given at 2, 4, and 6 months of age was well tolerated; immunogenicity was similar to the control vaccines.

Authors+Show Affiliations

Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

21215828

Citation

Lee, Soo Young, et al. "Immunogenicity and Safety of a Combined Diphtheria, Tetanus, Acellular Pertussis, and Inactivated Poliovirus Vaccine (DTaP-IPV) Compared to Separate Administration of Standalone DTaP and IPV Vaccines: a Randomized, Controlled Study in Infants in the Republic of Korea." Vaccine, vol. 29, no. 8, 2011, pp. 1551-7.
Lee SY, Hwang HS, Kim JH, et al. Immunogenicity and safety of a combined diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine (DTaP-IPV) compared to separate administration of standalone DTaP and IPV vaccines: a randomized, controlled study in infants in the Republic of Korea. Vaccine. 2011;29(8):1551-7.
Lee, S. Y., Hwang, H. S., Kim, J. H., Kim, H. H., Lee, H. S., Chung, E. H., Park, S. E., Ma, S. H., Chang, J. K., Guitton, F., Ortiz, E., & Kang, J. H. (2011). Immunogenicity and safety of a combined diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine (DTaP-IPV) compared to separate administration of standalone DTaP and IPV vaccines: a randomized, controlled study in infants in the Republic of Korea. Vaccine, 29(8), 1551-7. https://doi.org/10.1016/j.vaccine.2010.12.094
Lee SY, et al. Immunogenicity and Safety of a Combined Diphtheria, Tetanus, Acellular Pertussis, and Inactivated Poliovirus Vaccine (DTaP-IPV) Compared to Separate Administration of Standalone DTaP and IPV Vaccines: a Randomized, Controlled Study in Infants in the Republic of Korea. Vaccine. 2011 Feb 11;29(8):1551-7. PubMed PMID: 21215828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunogenicity and safety of a combined diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine (DTaP-IPV) compared to separate administration of standalone DTaP and IPV vaccines: a randomized, controlled study in infants in the Republic of Korea. AU - Lee,Soo Young, AU - Hwang,Hui Sung, AU - Kim,Jong Hyun, AU - Kim,Hyun Hee, AU - Lee,Hyun Seung, AU - Chung,Eun Hee, AU - Park,Su Eun, AU - Ma,Sang Hyuk, AU - Chang,Jin Keun, AU - Guitton,Fabrice, AU - Ortiz,Esteban, AU - Kang,Jin Han, Y1 - 2011/01/06/ PY - 2010/04/03/received PY - 2010/12/17/revised PY - 2010/12/21/accepted PY - 2011/1/11/entrez PY - 2011/1/11/pubmed PY - 2011/4/20/medline SP - 1551 EP - 7 JF - Vaccine JO - Vaccine VL - 29 IS - 8 N2 - This randomized trial enrolled 442 infants in the Republic of Korea to assess the immunogenicity and safety of a combined diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine (DTaP-IPV; Tetraxim™) for primary vaccination at 2, 4 and 6 months of age compared with DTaP and IPV vaccines given separately. Immunogenicity was high in both groups; seroprotection and seroconversion rates of the combined vaccine (Group A) were non-inferior to the control vaccines (Group B). All subjects were seroprotected against poliovirus types 1, 2 and 3 (≥ 81/dil) and anti-diphtheria (≥ 0.01 IU/mL); 99.0% were seroprotected against tetanus (≥ 0.1 IU/mL). At least 93.6% had anti-diphtheria antibody titers ≥ 0.1 IU/mL. Anti-pertussis toxoid (PT) and anti-filamentous haemagglutinin (FHA) seroconversion (≥ 4-fold increase in antibody titer) rates were 96.6% and 94.4% for Group A, 92.2% and 78.4% for Group B. Most solicited reactions occurred within 4 days of vaccination, resolved within 3 days and were mild. Severe solicited reactions occurred after ≤ 0.5% of doses in Group A and ≤ 0.9% in Group B. No withdrawals occurred because of adverse events. The DTaP-IPV combined vaccine given at 2, 4, and 6 months of age was well tolerated; immunogenicity was similar to the control vaccines. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21215828/Immunogenicity_and_safety_of_a_combined_diphtheria_tetanus_acellular_pertussis_and_inactivated_poliovirus_vaccine__DTaP_IPV__compared_to_separate_administration_of_standalone_DTaP_and_IPV_vaccines:_a_randomized_controlled_study_in_infants_in_the_Republic_of_Korea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(10)01878-5 DB - PRIME DP - Unbound Medicine ER -