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Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults.

Abstract

BACKGROUND

Current evidence supporting the effectiveness of influenza vaccine in preventing hospitalizations in older adults is insufficient.

METHODS

During 3 influenza seasons, 2006-2009, community-dwelling adults aged ≥50 y hospitalized with respiratory symptoms were prospectively enrolled in this study. We tested nose and throat samples for influenza virus by reverse transcriptase-polymerase chain reaction. We estimated vaccine effectiveness by comparing vaccination status between influenza-positive cases and influenza-negative controls using logistic regression models with propensity score adjustment.

RESULTS

Overall, 450 (59%) of 763 eligible patients were enrolled; 417 (93%) of enrolled patients had adequate respiratory samples, had known influenza vaccination status, and were community-dwelling. The proportions of influenza-positive patients were 8%, 20%, and 6% in the 3 successive seasons. Of 39 influenza-positive participants, 14 (36%) were vaccinated compared with 250 (66%) of 378 influenza-negative controls. Propensity score-adjusted vaccine effectiveness for the 3 seasons combined was 61.2% (95% confidence interval, 17.5%-81.8%).

CONCLUSION

Overall, in this moderately well-vaccinated population of older adults, laboratory-confirmed influenza virus accounted for 9.3% (95% confidence interval, 6.6%-12.1%) of all respiratory hospitalizations during 3 influenza seasons, and influenza vaccination prevented 61.2% of such hospitalizations.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. keipp.talbot@vanderbilt.edu

    , , , ,

    Source

    The Journal of infectious diseases 203:4 2011 Feb 15 pg 500-8

    MeSH

    Aged
    Aged, 80 and over
    Female
    Hospitalization
    Humans
    Influenza Vaccines
    Influenza, Human
    Male
    Middle Aged
    Nose
    Orthomyxoviridae
    Pharynx
    Prevalence
    Prospective Studies
    RNA, Viral
    Reverse Transcriptase Polymerase Chain Reaction
    Vaccination
    Virology

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    21220776

    Citation

    TY - JOUR T1 - Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults. AU - Talbot,H Keipp, AU - Griffin,Marie R, AU - Chen,Qingxia, AU - Zhu,Yuwei, AU - Williams,John V, AU - Edwards,Kathryn M, Y1 - 2011/01/10/ PY - 2011/1/10/aheadofprint PY - 2011/1/12/entrez PY - 2011/1/12/pubmed PY - 2011/2/25/medline SP - 500 EP - 8 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 203 IS - 4 N2 - BACKGROUND: Current evidence supporting the effectiveness of influenza vaccine in preventing hospitalizations in older adults is insufficient. METHODS: During 3 influenza seasons, 2006-2009, community-dwelling adults aged ≥50 y hospitalized with respiratory symptoms were prospectively enrolled in this study. We tested nose and throat samples for influenza virus by reverse transcriptase-polymerase chain reaction. We estimated vaccine effectiveness by comparing vaccination status between influenza-positive cases and influenza-negative controls using logistic regression models with propensity score adjustment. RESULTS: Overall, 450 (59%) of 763 eligible patients were enrolled; 417 (93%) of enrolled patients had adequate respiratory samples, had known influenza vaccination status, and were community-dwelling. The proportions of influenza-positive patients were 8%, 20%, and 6% in the 3 successive seasons. Of 39 influenza-positive participants, 14 (36%) were vaccinated compared with 250 (66%) of 378 influenza-negative controls. Propensity score-adjusted vaccine effectiveness for the 3 seasons combined was 61.2% (95% confidence interval, 17.5%-81.8%). CONCLUSION: Overall, in this moderately well-vaccinated population of older adults, laboratory-confirmed influenza virus accounted for 9.3% (95% confidence interval, 6.6%-12.1%) of all respiratory hospitalizations during 3 influenza seasons, and influenza vaccination prevented 61.2% of such hospitalizations. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/21220776/full_citation L2 - http://www.jid.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=21220776 ER -