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Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults.

Abstract

BACKGROUND

Current evidence supporting the effectiveness of influenza vaccine in preventing hospitalizations in older adults is insufficient.

METHODS

During 3 influenza seasons, 2006-2009, community-dwelling adults aged ≥50 y hospitalized with respiratory symptoms were prospectively enrolled in this study. We tested nose and throat samples for influenza virus by reverse transcriptase-polymerase chain reaction. We estimated vaccine effectiveness by comparing vaccination status between influenza-positive cases and influenza-negative controls using logistic regression models with propensity score adjustment.

RESULTS

Overall, 450 (59%) of 763 eligible patients were enrolled; 417 (93%) of enrolled patients had adequate respiratory samples, had known influenza vaccination status, and were community-dwelling. The proportions of influenza-positive patients were 8%, 20%, and 6% in the 3 successive seasons. Of 39 influenza-positive participants, 14 (36%) were vaccinated compared with 250 (66%) of 378 influenza-negative controls. Propensity score-adjusted vaccine effectiveness for the 3 seasons combined was 61.2% (95% confidence interval, 17.5%-81.8%).

CONCLUSION

Overall, in this moderately well-vaccinated population of older adults, laboratory-confirmed influenza virus accounted for 9.3% (95% confidence interval, 6.6%-12.1%) of all respiratory hospitalizations during 3 influenza seasons, and influenza vaccination prevented 61.2% of such hospitalizations.

Links

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Publisher Full Text

Grapherence [↓36 ↑26]

Authors+Show Affiliations

Talbot HK

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. keipp.talbot@vanderbilt.edu

Source

The Journal of infectious diseases 203:4 2011 Feb 15 pg 500-8

MeSH

Aged
Aged, 80 and over
Female
Hospitalization
Humans
Influenza Vaccines
Influenza, Human
Male
Middle Aged
Nose
Orthomyxoviridae
Pharynx
Prevalence
Prospective Studies
RNA, Viral
Reverse Transcriptase Polymerase Chain Reaction
Vaccination
Virology

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

21220776

Citation

Chen, Qingxia, et al. "Effectiveness of Seasonal Vaccine in Preventing Confirmed Influenza-associated Hospitalizations in Community Dwelling Older Adults." The Journal of Infectious Diseases, vol. 203, no. 4, 2011, pp. 500-8. Unbound PRIME, www.unboundmedicine.com/medline/citation/21220776/full_citation. Accessed February 21, 2019.

Chen Q, Edwards KM, Griffin MR, et al. Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults. J Infect Dis. 2011;203(4):500-8.  https://www.unboundmedicine.com/medline/citation/21220776/full_citation. Accessed February 21, 2019.

Chen, Q., Edwards, K. M., Griffin, M. R., Talbot, H. K., Williams, J. V., & Zhu, Y. (2011). Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults. The Journal of Infectious Diseases, 203(4), pp. 500-8. doi:10.1093/infdis/jiq076

Chen Q, et al. Effectiveness of Seasonal Vaccine in Preventing Confirmed Influenza-associated Hospitalizations in Community Dwelling Older Adults [Internet]. J Infect Dis. 2011 Feb 15 [cited 2019 Feb 21];203(4):500-8. Available from: https://www.unboundmedicine.com/medline/citation/21220776/full_citation doi: 10.1093/infdis/jiq076

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TY - JOUR T1 - Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults. AU - Talbot,H Keipp, AU - Griffin,Marie R, AU - Chen,Qingxia, AU - Zhu,Yuwei, AU - Williams,John V, AU - Edwards,Kathryn M, Y1 - 2011/01/10/ PY - 2011/1/12/entrez PY - 2011/1/12/pubmed PY - 2011/2/25/medline SP - 500 EP - 8 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 203 IS - 4 N2 - BACKGROUND: Current evidence supporting the effectiveness of influenza vaccine in preventing hospitalizations in older adults is insufficient. METHODS: During 3 influenza seasons, 2006-2009, community-dwelling adults aged ≥50 y hospitalized with respiratory symptoms were prospectively enrolled in this study. We tested nose and throat samples for influenza virus by reverse transcriptase-polymerase chain reaction. We estimated vaccine effectiveness by comparing vaccination status between influenza-positive cases and influenza-negative controls using logistic regression models with propensity score adjustment. RESULTS: Overall, 450 (59%) of 763 eligible patients were enrolled; 417 (93%) of enrolled patients had adequate respiratory samples, had known influenza vaccination status, and were community-dwelling. The proportions of influenza-positive patients were 8%, 20%, and 6% in the 3 successive seasons. Of 39 influenza-positive participants, 14 (36%) were vaccinated compared with 250 (66%) of 378 influenza-negative controls. Propensity score-adjusted vaccine effectiveness for the 3 seasons combined was 61.2% (95% confidence interval, 17.5%-81.8%). CONCLUSION: Overall, in this moderately well-vaccinated population of older adults, laboratory-confirmed influenza virus accounted for 9.3% (95% confidence interval, 6.6%-12.1%) of all respiratory hospitalizations during 3 influenza seasons, and influenza vaccination prevented 61.2% of such hospitalizations. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/21220776/full_citation L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiq076 DB - PRIME DP - Unbound Medicine ER -