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Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults.
J Infect Dis 2011; 203(4):500-8JI

Abstract

BACKGROUND

Current evidence supporting the effectiveness of influenza vaccine in preventing hospitalizations in older adults is insufficient.

METHODS

During 3 influenza seasons, 2006-2009, community-dwelling adults aged ≥50 y hospitalized with respiratory symptoms were prospectively enrolled in this study. We tested nose and throat samples for influenza virus by reverse transcriptase-polymerase chain reaction. We estimated vaccine effectiveness by comparing vaccination status between influenza-positive cases and influenza-negative controls using logistic regression models with propensity score adjustment.

RESULTS

Overall, 450 (59%) of 763 eligible patients were enrolled; 417 (93%) of enrolled patients had adequate respiratory samples, had known influenza vaccination status, and were community-dwelling. The proportions of influenza-positive patients were 8%, 20%, and 6% in the 3 successive seasons. Of 39 influenza-positive participants, 14 (36%) were vaccinated compared with 250 (66%) of 378 influenza-negative controls. Propensity score-adjusted vaccine effectiveness for the 3 seasons combined was 61.2% (95% confidence interval, 17.5%-81.8%).

CONCLUSION

Overall, in this moderately well-vaccinated population of older adults, laboratory-confirmed influenza virus accounted for 9.3% (95% confidence interval, 6.6%-12.1%) of all respiratory hospitalizations during 3 influenza seasons, and influenza vaccination prevented 61.2% of such hospitalizations.

Authors+Show Affiliations

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. keipp.talbot@vanderbilt.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

21220776

Citation

Talbot, H Keipp, et al. "Effectiveness of Seasonal Vaccine in Preventing Confirmed Influenza-associated Hospitalizations in Community Dwelling Older Adults." The Journal of Infectious Diseases, vol. 203, no. 4, 2011, pp. 500-8.
Talbot HK, Griffin MR, Chen Q, et al. Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults. J Infect Dis. 2011;203(4):500-8.
Talbot, H. K., Griffin, M. R., Chen, Q., Zhu, Y., Williams, J. V., & Edwards, K. M. (2011). Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults. The Journal of Infectious Diseases, 203(4), pp. 500-8. doi:10.1093/infdis/jiq076.
Talbot HK, et al. Effectiveness of Seasonal Vaccine in Preventing Confirmed Influenza-associated Hospitalizations in Community Dwelling Older Adults. J Infect Dis. 2011 Feb 15;203(4):500-8. PubMed PMID: 21220776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults. AU - Talbot,H Keipp, AU - Griffin,Marie R, AU - Chen,Qingxia, AU - Zhu,Yuwei, AU - Williams,John V, AU - Edwards,Kathryn M, Y1 - 2011/01/10/ PY - 2011/1/12/entrez PY - 2011/1/12/pubmed PY - 2011/2/25/medline SP - 500 EP - 8 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 203 IS - 4 N2 - BACKGROUND: Current evidence supporting the effectiveness of influenza vaccine in preventing hospitalizations in older adults is insufficient. METHODS: During 3 influenza seasons, 2006-2009, community-dwelling adults aged ≥50 y hospitalized with respiratory symptoms were prospectively enrolled in this study. We tested nose and throat samples for influenza virus by reverse transcriptase-polymerase chain reaction. We estimated vaccine effectiveness by comparing vaccination status between influenza-positive cases and influenza-negative controls using logistic regression models with propensity score adjustment. RESULTS: Overall, 450 (59%) of 763 eligible patients were enrolled; 417 (93%) of enrolled patients had adequate respiratory samples, had known influenza vaccination status, and were community-dwelling. The proportions of influenza-positive patients were 8%, 20%, and 6% in the 3 successive seasons. Of 39 influenza-positive participants, 14 (36%) were vaccinated compared with 250 (66%) of 378 influenza-negative controls. Propensity score-adjusted vaccine effectiveness for the 3 seasons combined was 61.2% (95% confidence interval, 17.5%-81.8%). CONCLUSION: Overall, in this moderately well-vaccinated population of older adults, laboratory-confirmed influenza virus accounted for 9.3% (95% confidence interval, 6.6%-12.1%) of all respiratory hospitalizations during 3 influenza seasons, and influenza vaccination prevented 61.2% of such hospitalizations. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/21220776/full_citation L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiq076 DB - PRIME DP - Unbound Medicine ER -