TY - JOUR T1 - Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults. AU - Talbot,H Keipp, AU - Griffin,Marie R, AU - Chen,Qingxia, AU - Zhu,Yuwei, AU - Williams,John V, AU - Edwards,Kathryn M, Y1 - 2011/01/10/ PY - 2011/1/12/entrez PY - 2011/1/12/pubmed PY - 2011/2/25/medline SP - 500 EP - 8 JF - The Journal of infectious diseases JO - J Infect Dis VL - 203 IS - 4 N2 - BACKGROUND: Current evidence supporting the effectiveness of influenza vaccine in preventing hospitalizations in older adults is insufficient. METHODS: During 3 influenza seasons, 2006-2009, community-dwelling adults aged ≥50 y hospitalized with respiratory symptoms were prospectively enrolled in this study. We tested nose and throat samples for influenza virus by reverse transcriptase-polymerase chain reaction. We estimated vaccine effectiveness by comparing vaccination status between influenza-positive cases and influenza-negative controls using logistic regression models with propensity score adjustment. RESULTS: Overall, 450 (59%) of 763 eligible patients were enrolled; 417 (93%) of enrolled patients had adequate respiratory samples, had known influenza vaccination status, and were community-dwelling. The proportions of influenza-positive patients were 8%, 20%, and 6% in the 3 successive seasons. Of 39 influenza-positive participants, 14 (36%) were vaccinated compared with 250 (66%) of 378 influenza-negative controls. Propensity score-adjusted vaccine effectiveness for the 3 seasons combined was 61.2% (95% confidence interval, 17.5%-81.8%). CONCLUSION: Overall, in this moderately well-vaccinated population of older adults, laboratory-confirmed influenza virus accounted for 9.3% (95% confidence interval, 6.6%-12.1%) of all respiratory hospitalizations during 3 influenza seasons, and influenza vaccination prevented 61.2% of such hospitalizations. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/21220776/full_citation L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiq076 DB - PRIME DP - Unbound Medicine ER -