Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults.
Abstract
BACKGROUND
Current evidence supporting the effectiveness of influenza vaccine in preventing hospitalizations in older adults is insufficient.METHODS
During 3 influenza seasons, 2006-2009, community-dwelling adults aged ≥50 y hospitalized with respiratory symptoms were prospectively enrolled in this study. We tested nose and throat samples for influenza virus by reverse transcriptase-polymerase chain reaction. We estimated vaccine effectiveness by comparing vaccination status between influenza-positive cases and influenza-negative controls using logistic regression models with propensity score adjustment.RESULTS
Overall, 450 (59%) of 763 eligible patients were enrolled; 417 (93%) of enrolled patients had adequate respiratory samples, had known influenza vaccination status, and were community-dwelling. The proportions of influenza-positive patients were 8%, 20%, and 6% in the 3 successive seasons. Of 39 influenza-positive participants, 14 (36%) were vaccinated compared with 250 (66%) of 378 influenza-negative controls. Propensity score-adjusted vaccine effectiveness for the 3 seasons combined was 61.2% (95% confidence interval, 17.5%-81.8%).CONCLUSION
Overall, in this moderately well-vaccinated population of older adults, laboratory-confirmed influenza virus accounted for 9.3% (95% confidence interval, 6.6%-12.1%) of all respiratory hospitalizations during 3 influenza seasons, and influenza vaccination prevented 61.2% of such hospitalizations.Links
Authors+Show Affiliations
,Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. keipp.talbot@vanderbilt.edu
, , , ,Source
The Journal of infectious diseases 203:4 2011 Feb 15 pg 500-8
MeSH
AgedAged, 80 and over
Female
Hospitalization
Humans
Influenza Vaccines
Influenza, Human
Male
Middle Aged
Nose
Orthomyxoviridae
Pharynx
Prevalence
Prospective Studies
RNA, Viral
Reverse Transcriptase Polymerase Chain Reaction
Vaccination
Virology
Pub Type(s)
Journal ArticleResearch Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Language
eng
PubMed ID
21220776
Citation
* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults.
AU - Talbot,H Keipp,
AU - Griffin,Marie R,
AU - Chen,Qingxia,
AU - Zhu,Yuwei,
AU - Williams,John V,
AU - Edwards,Kathryn M,
Y1 - 2011/01/10/
PY - 2011/1/12/entrez
PY - 2011/1/12/pubmed
PY - 2011/2/25/medline
SP - 500
EP - 8
JF - The Journal of infectious diseases
JO - J. Infect. Dis.
VL - 203
IS - 4
N2 - BACKGROUND: Current evidence supporting the effectiveness of influenza vaccine in preventing hospitalizations in older adults is insufficient. METHODS: During 3 influenza seasons, 2006-2009, community-dwelling adults aged ≥50 y hospitalized with respiratory symptoms were prospectively enrolled in this study. We tested nose and throat samples for influenza virus by reverse transcriptase-polymerase chain reaction. We estimated vaccine effectiveness by comparing vaccination status between influenza-positive cases and influenza-negative controls using logistic regression models with propensity score adjustment. RESULTS: Overall, 450 (59%) of 763 eligible patients were enrolled; 417 (93%) of enrolled patients had adequate respiratory samples, had known influenza vaccination status, and were community-dwelling. The proportions of influenza-positive patients were 8%, 20%, and 6% in the 3 successive seasons. Of 39 influenza-positive participants, 14 (36%) were vaccinated compared with 250 (66%) of 378 influenza-negative controls. Propensity score-adjusted vaccine effectiveness for the 3 seasons combined was 61.2% (95% confidence interval, 17.5%-81.8%). CONCLUSION: Overall, in this moderately well-vaccinated population of older adults, laboratory-confirmed influenza virus accounted for 9.3% (95% confidence interval, 6.6%-12.1%) of all respiratory hospitalizations during 3 influenza seasons, and influenza vaccination prevented 61.2% of such hospitalizations.
SN - 1537-6613
UR - https://www.unboundmedicine.com/medline/citation/21220776/full_citation
L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiq076
DB - PRIME
DP - Unbound Medicine
ER -