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Asymptomatic Alzheimer's disease: a prodrome or a state of resilience?
Curr Alzheimer Res. 2011 Jun; 8(4):330-5.CA

Abstract

Neuritic plaques and neurofibrillary tangles, the neuropathological hallmarks of AD, are not limited to individuals with dementia. These pathologic changes can also be present in the brains of cognitively normal older adults - a condition we defined as Asymptomatic AD (ASYMAD). Although it remains unclear whether these individuals would remain clinically normal with longer survival, they seem to be able to compensate for or delay the appearance of dementia symptoms. Here, we provide a historical background and highlight the combined clinical, pathologic and morphometric evidence related to ASYMAD. Understanding the nature of changes during this apparently asymptomatic state may shed light on the mechanisms that forestall the progression of the disease and allow for maintenance of cognitive health, an important area of research that has been understudied relative to the identification of risks and pathways to negative health outcomes.

Authors+Show Affiliations

National Institute on Aging, NIH, Baltimore, MD, USA. driscolli@mail.nih.govNo affiliation info available

Pub Type(s)

Historical Article
Journal Article
Review

Language

eng

PubMed ID

21222594

Citation

Driscoll, I, and J Troncoso. "Asymptomatic Alzheimer's Disease: a Prodrome or a State of Resilience?" Current Alzheimer Research, vol. 8, no. 4, 2011, pp. 330-5.
Driscoll I, Troncoso J. Asymptomatic Alzheimer's disease: a prodrome or a state of resilience? Curr Alzheimer Res. 2011;8(4):330-5.
Driscoll, I., & Troncoso, J. (2011). Asymptomatic Alzheimer's disease: a prodrome or a state of resilience? Current Alzheimer Research, 8(4), 330-5.
Driscoll I, Troncoso J. Asymptomatic Alzheimer's Disease: a Prodrome or a State of Resilience. Curr Alzheimer Res. 2011;8(4):330-5. PubMed PMID: 21222594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymptomatic Alzheimer's disease: a prodrome or a state of resilience? AU - Driscoll,I, AU - Troncoso,J, PY - 2010/08/11/received PY - 2010/12/22/accepted PY - 2011/1/13/entrez PY - 2011/1/13/pubmed PY - 2011/12/24/medline SP - 330 EP - 5 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 8 IS - 4 N2 - Neuritic plaques and neurofibrillary tangles, the neuropathological hallmarks of AD, are not limited to individuals with dementia. These pathologic changes can also be present in the brains of cognitively normal older adults - a condition we defined as Asymptomatic AD (ASYMAD). Although it remains unclear whether these individuals would remain clinically normal with longer survival, they seem to be able to compensate for or delay the appearance of dementia symptoms. Here, we provide a historical background and highlight the combined clinical, pathologic and morphometric evidence related to ASYMAD. Understanding the nature of changes during this apparently asymptomatic state may shed light on the mechanisms that forestall the progression of the disease and allow for maintenance of cognitive health, an important area of research that has been understudied relative to the identification of risks and pathways to negative health outcomes. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/21222594/Asymptomatic_Alzheimer's_disease:_a_prodrome_or_a_state_of_resilience L2 - http://www.eurekaselect.com/88116/article DB - PRIME DP - Unbound Medicine ER -