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[Comparison of touch imprint cytology of core needle biopsy and section histopathology in breast cancer diagnosis].
Zhonghua Zhong Liu Za Zhi. 2010 Dec; 32(12):921-6.ZZ

Abstract

OBJECTIVE

To evaluate the sensitivity, specificity of touch imprint cytology (TIC), and to compare its conformity rate with histopathology, to observe the consistence of immunocytochemistry (ICC) with immunohistochemistry (IHC), and to assess the diagnostic value of TIC prior to neoadjuvant chemotherapy for breast cancer.

METHODS

289 cases of TIC and 287 cases with core needle biopsy (CNB) histopathology accumulated from October 2005 to October 2008 in our hospital were included in this study. One hundred ninety cases TIC results were compared with that of final histopathology. 64 cases were tested for ER, PR, HER-2 by immunocytochemistry.

RESULTS

Twenty-four benign cases and 263 malignant cases were diagnosed. 4 specimens were unsatisfactory. False negative rate and unsatisfactory rate were 1.4%, both, and false positive rate was 0.35%. The accuracy rate of TIC and CNB was 95.8% and 95.3%, respectively (P = 0.804). The sensitivity of TIC and CNB was 96.2% and 95.0% (P = 0.601), specificity 87.5% and 100% (P = 0.471) were found, when compared with the results of routine histopathology. 52 cases had a control with IHC of CNB in 64 ICC, and 43 cases had a final histopathology IHC. The ICC conformity rate of ER, PR, HER-2 with IHC of CNB was 86.5%, 75.0%, 78.8%, and that with IHC of final histopathology was 88.4%, 74.4%, 75.6%, respectively. The conformity rate of IHC between CNB and final histopathology was 83.7%, 74.4%, 76.5%, respectively. There was no significant statistical difference between them.

CONCLUSION

Compared with routine CNB histopathology, TIC has a high accuracy and sensitivity, and can provide a rapid and reliable cytological diagnosis to complement CNB for breast lesions. The conformity rates are high in ER, PR, HER-2 expression between ICC and IHC. ICC of TIC can be used to determine the estrogen and progesterone receptor levels in breast cancer before neoadjuvant chemotherapy.

Authors+Show Affiliations

Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

21223801

Citation

Zhang, Zhi-Hui, et al. "[Comparison of Touch Imprint Cytology of Core Needle Biopsy and Section Histopathology in Breast Cancer Diagnosis]." Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], vol. 32, no. 12, 2010, pp. 921-6.
Zhang ZH, Zhao LL, Guo HQ, et al. [Comparison of touch imprint cytology of core needle biopsy and section histopathology in breast cancer diagnosis]. Zhonghua Zhong Liu Za Zhi. 2010;32(12):921-6.
Zhang, Z. H., Zhao, L. L., Guo, H. Q., Zheng, S., Zhang, B. L., Xu, X. Z., Pan, Q. J., & Zhang, B. N. (2010). [Comparison of touch imprint cytology of core needle biopsy and section histopathology in breast cancer diagnosis]. Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology], 32(12), 921-6.
Zhang ZH, et al. [Comparison of Touch Imprint Cytology of Core Needle Biopsy and Section Histopathology in Breast Cancer Diagnosis]. Zhonghua Zhong Liu Za Zhi. 2010;32(12):921-6. PubMed PMID: 21223801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparison of touch imprint cytology of core needle biopsy and section histopathology in breast cancer diagnosis]. AU - Zhang,Zhi-Hui, AU - Zhao,Lin-Lin, AU - Guo,Hui-Qin, AU - Zheng,Shan, AU - Zhang,Bai-Lin, AU - Xu,Xiao-Zhou, AU - Pan,Qin-Jing, AU - Zhang,Bao-Ning, PY - 2011/1/13/entrez PY - 2011/1/13/pubmed PY - 2011/12/13/medline SP - 921 EP - 6 JF - Zhonghua zhong liu za zhi [Chinese journal of oncology] JO - Zhonghua Zhong Liu Za Zhi VL - 32 IS - 12 N2 - OBJECTIVE: To evaluate the sensitivity, specificity of touch imprint cytology (TIC), and to compare its conformity rate with histopathology, to observe the consistence of immunocytochemistry (ICC) with immunohistochemistry (IHC), and to assess the diagnostic value of TIC prior to neoadjuvant chemotherapy for breast cancer. METHODS: 289 cases of TIC and 287 cases with core needle biopsy (CNB) histopathology accumulated from October 2005 to October 2008 in our hospital were included in this study. One hundred ninety cases TIC results were compared with that of final histopathology. 64 cases were tested for ER, PR, HER-2 by immunocytochemistry. RESULTS: Twenty-four benign cases and 263 malignant cases were diagnosed. 4 specimens were unsatisfactory. False negative rate and unsatisfactory rate were 1.4%, both, and false positive rate was 0.35%. The accuracy rate of TIC and CNB was 95.8% and 95.3%, respectively (P = 0.804). The sensitivity of TIC and CNB was 96.2% and 95.0% (P = 0.601), specificity 87.5% and 100% (P = 0.471) were found, when compared with the results of routine histopathology. 52 cases had a control with IHC of CNB in 64 ICC, and 43 cases had a final histopathology IHC. The ICC conformity rate of ER, PR, HER-2 with IHC of CNB was 86.5%, 75.0%, 78.8%, and that with IHC of final histopathology was 88.4%, 74.4%, 75.6%, respectively. The conformity rate of IHC between CNB and final histopathology was 83.7%, 74.4%, 76.5%, respectively. There was no significant statistical difference between them. CONCLUSION: Compared with routine CNB histopathology, TIC has a high accuracy and sensitivity, and can provide a rapid and reliable cytological diagnosis to complement CNB for breast lesions. The conformity rates are high in ER, PR, HER-2 expression between ICC and IHC. ICC of TIC can be used to determine the estrogen and progesterone receptor levels in breast cancer before neoadjuvant chemotherapy. SN - 0253-3766 UR - https://www.unboundmedicine.com/medline/citation/21223801/[Comparison_of_touch_imprint_cytology_of_core_needle_biopsy_and_section_histopathology_in_breast_cancer_diagnosis]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0253-3766&year=2010&vol=32&issue=12&fpage=921 DB - PRIME DP - Unbound Medicine ER -