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APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease.

Abstract

Prior studies reported that the hippocampal volume is smaller in Alzheimer's disease patients carrying the Apolipoprotein E ε4 allele (APOE4) versus patients who are non-carriers of this allele. This effect however has not been detected consistently, possibly because of the regionally-specific involvement of the hippocampal formation in Alzheimer's disease. The aim of this study was to analyze the local effect of APOE4 on hippocampal atrophy in Alzheimer's disease patients. Using high-resolution T1-weighted images we investigated 14 patients heterozygous for the ε4 allele (age 72±8 SD years; MMSE 20±4 SD) and 14 patients not carrying the ε4 allele (age 71±10; MMSE 20±5 SD), and 28 age-, sex-, and education-matched controls (age 71±8; MMSE 29±1 SD). The hippocampal formation was outlined with manual tracing and 3D parametric surface models were created for each subject. Radial atrophy was assessed on the whole hippocampal surface using the UCLA mapping technique. E4 carriers and non-carriers did not differ in their level of impairment in global cognition (p=0.91, Mann-Whitney test) or memory (p>0.29). Hippocampal surface analysis showed the typical pattern of CA1 and subicular tissue atrophy in both ε4-carriers and non-carriers compared with controls (e4 carriers: p<0.0002; ε4 non-carriers: p<0.01, permutation test). The left hippocampal volume was significantly smaller in ε4-carriers than non-carriers (p=0.044, Mann-Whitney test), the effect of APOE4 mapping to the subicular/CA1 region (p=0.041, permutation test). Differences were not statistically significant in the right hippocampus (p>0.20, permutation test). These findings show that hippocampal atrophy is greater in APOE4 carriers in regions typically affected by pathology. APOE4 may affect the structural expression of Alzheimer's disease.

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  • Authors+Show Affiliations

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    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio, FBF, Brescia, Italy.

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    Source

    NeuroImage 55:3 2011 Apr 01 pg 909-19

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Apolipoprotein E4
    Atrophy
    Attention
    Brain Mapping
    Cerebral Cortex
    Cognition
    Education
    Executive Function
    Female
    Functional Laterality
    Heterozygote
    Hippocampus
    Humans
    Image Processing, Computer-Assisted
    Magnetic Resonance Imaging
    Male
    Memory
    Neuropsychological Tests

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21224004

    Citation

    Pievani, Michela, et al. "APOE4 Is Associated With Greater Atrophy of the Hippocampal Formation in Alzheimer's Disease." NeuroImage, vol. 55, no. 3, 2011, pp. 909-19.
    Pievani M, Galluzzi S, Thompson PM, et al. APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease. Neuroimage. 2011;55(3):909-19.
    Pievani, M., Galluzzi, S., Thompson, P. M., Rasser, P. E., Bonetti, M., & Frisoni, G. B. (2011). APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease. NeuroImage, 55(3), pp. 909-19. doi:10.1016/j.neuroimage.2010.12.081.
    Pievani M, et al. APOE4 Is Associated With Greater Atrophy of the Hippocampal Formation in Alzheimer's Disease. Neuroimage. 2011 Apr 1;55(3):909-19. PubMed PMID: 21224004.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease. AU - Pievani,Michela, AU - Galluzzi,Samantha, AU - Thompson,Paul M, AU - Rasser,Paul E, AU - Bonetti,Matteo, AU - Frisoni,Giovanni B, Y1 - 2011/01/09/ PY - 2010/07/13/received PY - 2010/12/17/revised PY - 2010/12/30/accepted PY - 2011/1/13/entrez PY - 2011/1/13/pubmed PY - 2011/6/29/medline SP - 909 EP - 19 JF - NeuroImage JO - Neuroimage VL - 55 IS - 3 N2 - Prior studies reported that the hippocampal volume is smaller in Alzheimer's disease patients carrying the Apolipoprotein E ε4 allele (APOE4) versus patients who are non-carriers of this allele. This effect however has not been detected consistently, possibly because of the regionally-specific involvement of the hippocampal formation in Alzheimer's disease. The aim of this study was to analyze the local effect of APOE4 on hippocampal atrophy in Alzheimer's disease patients. Using high-resolution T1-weighted images we investigated 14 patients heterozygous for the ε4 allele (age 72±8 SD years; MMSE 20±4 SD) and 14 patients not carrying the ε4 allele (age 71±10; MMSE 20±5 SD), and 28 age-, sex-, and education-matched controls (age 71±8; MMSE 29±1 SD). The hippocampal formation was outlined with manual tracing and 3D parametric surface models were created for each subject. Radial atrophy was assessed on the whole hippocampal surface using the UCLA mapping technique. E4 carriers and non-carriers did not differ in their level of impairment in global cognition (p=0.91, Mann-Whitney test) or memory (p>0.29). Hippocampal surface analysis showed the typical pattern of CA1 and subicular tissue atrophy in both ε4-carriers and non-carriers compared with controls (e4 carriers: p<0.0002; ε4 non-carriers: p<0.01, permutation test). The left hippocampal volume was significantly smaller in ε4-carriers than non-carriers (p=0.044, Mann-Whitney test), the effect of APOE4 mapping to the subicular/CA1 region (p=0.041, permutation test). Differences were not statistically significant in the right hippocampus (p>0.20, permutation test). These findings show that hippocampal atrophy is greater in APOE4 carriers in regions typically affected by pathology. APOE4 may affect the structural expression of Alzheimer's disease. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/21224004/APOE4_is_associated_with_greater_atrophy_of_the_hippocampal_formation_in_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(11)00005-X DB - PRIME DP - Unbound Medicine ER -