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Elevated risk of colorectal adenoma with Helicobacter pylori-related chronic gastritis: a population-based case-control study.
Int J Cancer. 2011 Dec 01; 129(11):2704-11.IJ

Abstract

This study investigated correlations between Helicobacter pylori infection or chronic atrophic gastritis (CAG) and risk of colorectal adenoma in a population-based case-control study. Subjects comprised asymptomatic, middle-aged, male Japanese factory workers who participated in an annual health check-up program, including cancer screening with colonoscopy. We selected 239 colorectal adenoma cases based on histological evaluation and 239 age-matched adenoma-free controls, and evaluated colorectal adenoma risk according to stage of H. pylori-related chronic gastritis as determined by serum tests for H. pylori antibody titer and pepsinogen. Subjects with colorectal adenoma were more likely to be smokers and have hypercholesterolemia. H. pylori infection was a risk factor for adenoma as a whole (crude odds ratio [OR]: 2.26, 95% confidence interval [CI]: 1.44-3.55). Analysis of distal adenoma cases showed that adenoma risk was significantly increased in the presence of H. pylori infection, but there was no further increase in risk with CAG. In contrast, proximal adenoma risk increased stepwise with the presence and progression of H. pylori-related chronic gastritis and showed a maximal and significant increase with CAG (crude OR: 4.51, 95% CI: 1.43-14.2). Subjects with more extensive and severe gastritis showed still higher risk not only for proximal but also for distal adenoma. H. pylori-related chronic gastritis is likely to be involved in the development of colorectal neoplasms, and its progression appears to increase the risk, particularly for proximal adenomas. Knowing the H. pylori-related chronic gastritis stage will probably be useful for evaluation of risk for colorectal neoplasia.

Authors+Show Affiliations

Department of Gastroenterology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama, Japan. izumiino@wakayama-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21225622

Citation

Inoue, Izumi, et al. "Elevated Risk of Colorectal Adenoma With Helicobacter Pylori-related Chronic Gastritis: a Population-based Case-control Study." International Journal of Cancer, vol. 129, no. 11, 2011, pp. 2704-11.
Inoue I, Mukoubayashi C, Yoshimura N, et al. Elevated risk of colorectal adenoma with Helicobacter pylori-related chronic gastritis: a population-based case-control study. Int J Cancer. 2011;129(11):2704-11.
Inoue, I., Mukoubayashi, C., Yoshimura, N., Niwa, T., Deguchi, H., Watanabe, M., Enomoto, S., Maekita, T., Ueda, K., Iguchi, M., Yanaoka, K., Tamai, H., Arii, K., Oka, M., Fujishiro, M., Takeshita, T., Iwane, M., Mohara, O., & Ichinose, M. (2011). Elevated risk of colorectal adenoma with Helicobacter pylori-related chronic gastritis: a population-based case-control study. International Journal of Cancer, 129(11), 2704-11. https://doi.org/10.1002/ijc.25931
Inoue I, et al. Elevated Risk of Colorectal Adenoma With Helicobacter Pylori-related Chronic Gastritis: a Population-based Case-control Study. Int J Cancer. 2011 Dec 1;129(11):2704-11. PubMed PMID: 21225622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated risk of colorectal adenoma with Helicobacter pylori-related chronic gastritis: a population-based case-control study. AU - Inoue,Izumi, AU - Mukoubayashi,Chizu, AU - Yoshimura,Noriko, AU - Niwa,Tohru, AU - Deguchi,Hisanobu, AU - Watanabe,Mika, AU - Enomoto,Shotaro, AU - Maekita,Takao, AU - Ueda,Kazuki, AU - Iguchi,Mikitaka, AU - Yanaoka,Kimihiko, AU - Tamai,Hideyuki, AU - Arii,Kenji, AU - Oka,Masashi, AU - Fujishiro,Mitsuhiro, AU - Takeshita,Tatsuya, AU - Iwane,Masataka, AU - Mohara,Osamu, AU - Ichinose,Masao, Y1 - 2011/03/08/ PY - 2010/07/21/received PY - 2010/12/22/accepted PY - 2011/1/13/entrez PY - 2011/1/13/pubmed PY - 2011/12/13/medline SP - 2704 EP - 11 JF - International journal of cancer JO - Int J Cancer VL - 129 IS - 11 N2 - This study investigated correlations between Helicobacter pylori infection or chronic atrophic gastritis (CAG) and risk of colorectal adenoma in a population-based case-control study. Subjects comprised asymptomatic, middle-aged, male Japanese factory workers who participated in an annual health check-up program, including cancer screening with colonoscopy. We selected 239 colorectal adenoma cases based on histological evaluation and 239 age-matched adenoma-free controls, and evaluated colorectal adenoma risk according to stage of H. pylori-related chronic gastritis as determined by serum tests for H. pylori antibody titer and pepsinogen. Subjects with colorectal adenoma were more likely to be smokers and have hypercholesterolemia. H. pylori infection was a risk factor for adenoma as a whole (crude odds ratio [OR]: 2.26, 95% confidence interval [CI]: 1.44-3.55). Analysis of distal adenoma cases showed that adenoma risk was significantly increased in the presence of H. pylori infection, but there was no further increase in risk with CAG. In contrast, proximal adenoma risk increased stepwise with the presence and progression of H. pylori-related chronic gastritis and showed a maximal and significant increase with CAG (crude OR: 4.51, 95% CI: 1.43-14.2). Subjects with more extensive and severe gastritis showed still higher risk not only for proximal but also for distal adenoma. H. pylori-related chronic gastritis is likely to be involved in the development of colorectal neoplasms, and its progression appears to increase the risk, particularly for proximal adenomas. Knowing the H. pylori-related chronic gastritis stage will probably be useful for evaluation of risk for colorectal neoplasia. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21225622/Elevated_risk_of_colorectal_adenoma_with_Helicobacter_pylori_related_chronic_gastritis:_a_population_based_case_control_study_ L2 - https://doi.org/10.1002/ijc.25931 DB - PRIME DP - Unbound Medicine ER -