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Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women: the Women's Health Initiative Memory Study.
J Am Geriatr Soc 2011; 59(1):57-66JA

Abstract

OBJECTIVES

To examine whether significant depressive symptoms in postmenopausal women increases the risk of subsequent mild cognitive impairment (MCI) and dementia.

DESIGN

Prospective cohort study.

SETTING

Thirty nine of the 40 Women's Health Initiative (WHI) clinical centers that participated in a randomized clinical trial of hormone therapy.

PARTICIPANTS

Six thousand three hundred seventy-six postmenopausal women without cognitive impairment aged 65 to 79 at baseline.

MEASUREMENTS

Depressive disorders were assessed using an eight-item Burnam algorithm and followed annually for a mean period of 5.4 years. A central adjudication committee classified the presence of MCI and probable dementia based on an extensive neuropsychiatric examination.

RESULTS

Eight percent of postmenopausal women in this sample reported depressive symptoms above a 0.06 cut point on the Burnam algorithm. Depressive disorder at baseline was associated with greater risk of incident MCI (hazard ratio (HR)=1.98, 95% confidence interval (CI)=1.33-2.94), probable dementia (HR=2.03, 95% CI=1.15-3.60), and MCI or probable dementia (HR=1.92, 95% CI=1.35-2.73) after controlling for sociodemographic characteristics, lifestyle and vascular risk factors, cardiovascular and cerebrovascular disease, antidepressant use, and current and past hormone therapy status. Assignment to hormone therapy and baseline cognitive function did not affect these relationships. Women without depression who endorsed a remote history of depression had a higher risk of developing dementia.

CONCLUSION

Clinically significant depressive symptoms in women aged 65 and older are independently associated with greater incidence of MCI and probable dementia.

Authors+Show Affiliations

From the Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. jgoveas@mcw.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

21226676

Citation

Goveas, Joseph S., et al. "Depressive Symptoms and Incidence of Mild Cognitive Impairment and Probable Dementia in Elderly Women: the Women's Health Initiative Memory Study." Journal of the American Geriatrics Society, vol. 59, no. 1, 2011, pp. 57-66.
Goveas JS, Espeland MA, Woods NF, et al. Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women: the Women's Health Initiative Memory Study. J Am Geriatr Soc. 2011;59(1):57-66.
Goveas, J. S., Espeland, M. A., Woods, N. F., Wassertheil-Smoller, S., & Kotchen, J. M. (2011). Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women: the Women's Health Initiative Memory Study. Journal of the American Geriatrics Society, 59(1), pp. 57-66. doi:10.1111/j.1532-5415.2010.03233.x.
Goveas JS, et al. Depressive Symptoms and Incidence of Mild Cognitive Impairment and Probable Dementia in Elderly Women: the Women's Health Initiative Memory Study. J Am Geriatr Soc. 2011;59(1):57-66. PubMed PMID: 21226676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women: the Women's Health Initiative Memory Study. AU - Goveas,Joseph S, AU - Espeland,Mark A, AU - Woods,Nancy F, AU - Wassertheil-Smoller,Sylvia, AU - Kotchen,Jane M, PY - 2011/1/14/entrez PY - 2011/1/14/pubmed PY - 2011/2/22/medline SP - 57 EP - 66 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 59 IS - 1 N2 - OBJECTIVES: To examine whether significant depressive symptoms in postmenopausal women increases the risk of subsequent mild cognitive impairment (MCI) and dementia. DESIGN: Prospective cohort study. SETTING: Thirty nine of the 40 Women's Health Initiative (WHI) clinical centers that participated in a randomized clinical trial of hormone therapy. PARTICIPANTS: Six thousand three hundred seventy-six postmenopausal women without cognitive impairment aged 65 to 79 at baseline. MEASUREMENTS: Depressive disorders were assessed using an eight-item Burnam algorithm and followed annually for a mean period of 5.4 years. A central adjudication committee classified the presence of MCI and probable dementia based on an extensive neuropsychiatric examination. RESULTS: Eight percent of postmenopausal women in this sample reported depressive symptoms above a 0.06 cut point on the Burnam algorithm. Depressive disorder at baseline was associated with greater risk of incident MCI (hazard ratio (HR)=1.98, 95% confidence interval (CI)=1.33-2.94), probable dementia (HR=2.03, 95% CI=1.15-3.60), and MCI or probable dementia (HR=1.92, 95% CI=1.35-2.73) after controlling for sociodemographic characteristics, lifestyle and vascular risk factors, cardiovascular and cerebrovascular disease, antidepressant use, and current and past hormone therapy status. Assignment to hormone therapy and baseline cognitive function did not affect these relationships. Women without depression who endorsed a remote history of depression had a higher risk of developing dementia. CONCLUSION: Clinically significant depressive symptoms in women aged 65 and older are independently associated with greater incidence of MCI and probable dementia. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/21226676/Depressive_symptoms_and_incidence_of_mild_cognitive_impairment_and_probable_dementia_in_elderly_women:_the_Women's_Health_Initiative_Memory_Study_ L2 - https://doi.org/10.1111/j.1532-5415.2010.03233.x DB - PRIME DP - Unbound Medicine ER -