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Relationship between intima-media thickness of the common carotid artery and arterial stiffness in subjects with and without type 2 diabetes: a case-series report.
Cardiovasc Diabetol. 2011 Jan 12; 10:3.CD

Abstract

BACKGROUND

We examined the relationship between the intima-media thickness of the common carotid artery (CCA-IMT) and arterial stiffness, assessed by pulse wave velocity (PWV), the ambulatory arterial stiffness index (AASI) and the augmentation index (AIx) in subjects with and without type 2 diabetes.

METHODS

A case-series study was made in 366 patients (105 diabetics and 261-non-diabetics). Ambulatory blood pressure monitoring was performed on a day of standard activity with the SpaceLabs 90207 system. AASI was calculated as "1-slope" from the within-person regression of diastolic-on-systolic ambulatory blood pressure readings. PWV and AIx were measured with the SphygmoCor system, and a Sonosite Micromax ultrasound unit was used for automatic measurements of CCA-IMT.

RESULTS

PWV, AASI and CCA-IMT were found to be greater in diabetic patients, while no differences in AIx were observed between the two groups. CCA-IMT was independently correlated to the three measures of arterial stiffness in both groups. We found an increase in CCA-IMT of 0.40, 0.24 and 0.36 mm in diabetics, and of 0.48, 0.17 and 0.55 mm in non-diabetics for each unit increase in AASI, AIx and PWV. The variability of CCA-IMT was explained mainly by AASI, AIx and gender in diabetic patients, and by age, gender, AASI and PWV in non-diabetic patients.

CONCLUSIONS

CCA-IMT showed a positive correlation to PWV, AASI and AIx in subjects with and without type 2 diabetes. However, when adjusting for age, gender and heart rate, the association to PWV was lost in diabetic patients, in the same way as the association to Alx in non-diabetic patients. The present study demonstrates that the three measures taken to assess arterial stiffness in clinical practice are not interchangeable, nor do they behave equally in all subjects.

Authors+Show Affiliations

Primary Care Research Unit, La Alamedilla Health Center, Salamanca, Spain. magomez@usal.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21226947

Citation

Gómez-Marcos, Manuel Angel, et al. "Relationship Between Intima-media Thickness of the Common Carotid Artery and Arterial Stiffness in Subjects With and Without Type 2 Diabetes: a Case-series Report." Cardiovascular Diabetology, vol. 10, 2011, p. 3.
Gómez-Marcos MA, Recio-Rodríguez JI, Patino-Alonso MC, et al. Relationship between intima-media thickness of the common carotid artery and arterial stiffness in subjects with and without type 2 diabetes: a case-series report. Cardiovasc Diabetol. 2011;10:3.
Gómez-Marcos, M. A., Recio-Rodríguez, J. I., Patino-Alonso, M. C., Agudo-Conde, C., Gómez-Sánchez, L., Rodríguez-Sánchez, E., Martín-Cantera, C., & García-Ortiz, L. (2011). Relationship between intima-media thickness of the common carotid artery and arterial stiffness in subjects with and without type 2 diabetes: a case-series report. Cardiovascular Diabetology, 10, 3. https://doi.org/10.1186/1475-2840-10-3
Gómez-Marcos MA, et al. Relationship Between Intima-media Thickness of the Common Carotid Artery and Arterial Stiffness in Subjects With and Without Type 2 Diabetes: a Case-series Report. Cardiovasc Diabetol. 2011 Jan 12;10:3. PubMed PMID: 21226947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between intima-media thickness of the common carotid artery and arterial stiffness in subjects with and without type 2 diabetes: a case-series report. AU - Gómez-Marcos,Manuel Angel, AU - Recio-Rodríguez,José Ignacio, AU - Patino-Alonso,María Carmen, AU - Agudo-Conde,Cristina, AU - Gómez-Sánchez,Leticia, AU - Rodríguez-Sánchez,Emiliano, AU - Martín-Cantera,Carlos, AU - García-Ortiz,Luís, Y1 - 2011/01/12/ PY - 2010/11/17/received PY - 2011/01/12/accepted PY - 2011/1/14/entrez PY - 2011/1/14/pubmed PY - 2011/5/17/medline SP - 3 EP - 3 JF - Cardiovascular diabetology JO - Cardiovasc Diabetol VL - 10 N2 - BACKGROUND: We examined the relationship between the intima-media thickness of the common carotid artery (CCA-IMT) and arterial stiffness, assessed by pulse wave velocity (PWV), the ambulatory arterial stiffness index (AASI) and the augmentation index (AIx) in subjects with and without type 2 diabetes. METHODS: A case-series study was made in 366 patients (105 diabetics and 261-non-diabetics). Ambulatory blood pressure monitoring was performed on a day of standard activity with the SpaceLabs 90207 system. AASI was calculated as "1-slope" from the within-person regression of diastolic-on-systolic ambulatory blood pressure readings. PWV and AIx were measured with the SphygmoCor system, and a Sonosite Micromax ultrasound unit was used for automatic measurements of CCA-IMT. RESULTS: PWV, AASI and CCA-IMT were found to be greater in diabetic patients, while no differences in AIx were observed between the two groups. CCA-IMT was independently correlated to the three measures of arterial stiffness in both groups. We found an increase in CCA-IMT of 0.40, 0.24 and 0.36 mm in diabetics, and of 0.48, 0.17 and 0.55 mm in non-diabetics for each unit increase in AASI, AIx and PWV. The variability of CCA-IMT was explained mainly by AASI, AIx and gender in diabetic patients, and by age, gender, AASI and PWV in non-diabetic patients. CONCLUSIONS: CCA-IMT showed a positive correlation to PWV, AASI and AIx in subjects with and without type 2 diabetes. However, when adjusting for age, gender and heart rate, the association to PWV was lost in diabetic patients, in the same way as the association to Alx in non-diabetic patients. The present study demonstrates that the three measures taken to assess arterial stiffness in clinical practice are not interchangeable, nor do they behave equally in all subjects. SN - 1475-2840 UR - https://www.unboundmedicine.com/medline/citation/21226947/Relationship_between_intima_media_thickness_of_the_common_carotid_artery_and_arterial_stiffness_in_subjects_with_and_without_type_2_diabetes:_a_case_series_report_ L2 - https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-10-3 DB - PRIME DP - Unbound Medicine ER -