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Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype.
J Gen Virol. 2011 Apr; 92(Pt 4):902-8.JG

Abstract

While performing a nationwide survey of hepatitis E virus (HEV) infection among 450 wild boars (Sus scrofa leucomystax) that had been captured in Japan between November 2005 and March 2010, we found 16 boars (3.6%) with ongoing HEV infection: 11 had genotype 3 HEV, four had genotype 4 HEV and the remaining boar was infected with HEV of an unrecognized genotype (designated wbJOY_06). The entire wbJOY_06 genome was sequenced and was found to comprise 7246 nt excluding the poly(A) tail. The wbJOY_06 isolate was highly divergent from known genotype 1-4 HEV isolates derived from humans, swine, wild boars, deer, mongoose and rabbits (n=145) by 22.6-27.7%, rat HEV isolates (n=2) by 46.0-46.2%, and avian HEV isolates (n=5) by 52.5-53.1% over the entire genome. A Simplot analysis revealed no significant recombination between the existing HEV strains of genotypes 1-4. Therefore, we propose that the wbJOY_06 isolate is the first member of a previously unidentified genotype.

Authors+Show Affiliations

Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke-Shi, Tochigi-Ken 329-0498, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21228128

Citation

Takahashi, Masaharu, et al. "Analysis of the Full-length Genome of a Hepatitis E Virus Isolate Obtained From a Wild Boar in Japan That Is Classifiable Into a Novel Genotype." The Journal of General Virology, vol. 92, no. Pt 4, 2011, pp. 902-8.
Takahashi M, Nishizawa T, Sato H, et al. Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype. J Gen Virol. 2011;92(Pt 4):902-8.
Takahashi, M., Nishizawa, T., Sato, H., Sato, Y., Jirintai, ., Nagashima, S., & Okamoto, H. (2011). Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype. The Journal of General Virology, 92(Pt 4), 902-8. https://doi.org/10.1099/vir.0.029470-0
Takahashi M, et al. Analysis of the Full-length Genome of a Hepatitis E Virus Isolate Obtained From a Wild Boar in Japan That Is Classifiable Into a Novel Genotype. J Gen Virol. 2011;92(Pt 4):902-8. PubMed PMID: 21228128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype. AU - Takahashi,Masaharu, AU - Nishizawa,Tsutomu, AU - Sato,Hiroyuki, AU - Sato,Yukihiro, AU - Jirintai,, AU - Nagashima,Shigeo, AU - Okamoto,Hiroaki, Y1 - 2011/01/12/ PY - 2011/1/14/entrez PY - 2011/1/14/pubmed PY - 2011/5/19/medline SP - 902 EP - 8 JF - The Journal of general virology JO - J Gen Virol VL - 92 IS - Pt 4 N2 - While performing a nationwide survey of hepatitis E virus (HEV) infection among 450 wild boars (Sus scrofa leucomystax) that had been captured in Japan between November 2005 and March 2010, we found 16 boars (3.6%) with ongoing HEV infection: 11 had genotype 3 HEV, four had genotype 4 HEV and the remaining boar was infected with HEV of an unrecognized genotype (designated wbJOY_06). The entire wbJOY_06 genome was sequenced and was found to comprise 7246 nt excluding the poly(A) tail. The wbJOY_06 isolate was highly divergent from known genotype 1-4 HEV isolates derived from humans, swine, wild boars, deer, mongoose and rabbits (n=145) by 22.6-27.7%, rat HEV isolates (n=2) by 46.0-46.2%, and avian HEV isolates (n=5) by 52.5-53.1% over the entire genome. A Simplot analysis revealed no significant recombination between the existing HEV strains of genotypes 1-4. Therefore, we propose that the wbJOY_06 isolate is the first member of a previously unidentified genotype. SN - 1465-2099 UR - https://www.unboundmedicine.com/medline/citation/21228128/Analysis_of_the_full_length_genome_of_a_hepatitis_E_virus_isolate_obtained_from_a_wild_boar_in_Japan_that_is_classifiable_into_a_novel_genotype_ L2 - http://jgv.microbiologyresearch.org/pubmed/content/journal/jgv/10.1099/vir.0.029470-0 DB - PRIME DP - Unbound Medicine ER -