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Attenuated maximal muscle strength and peak power in children with sickle cell disease.
J Pediatr Hematol Oncol. 2011 Mar; 33(2):93-7.JP

Abstract

Dominant hand maximal handgrip strength evaluated with a handgrip dynamometer and peak power evaluated with a force plate, adjusted for body size and composition, were compared in African-American children aged 5 to 13 years, with and without type SS sickle cell disease (SCD-SS). Children with SCD-SS (n = 35; age, 9.0 ± 2.0 y) compared with healthy control children (n = 103; age, 8.6 ± 1.8 y) did not differ by age, sex, or pubertal status, yet had significantly lower Z scores for height, weight, body mass index, upper arm muscle area, upper arm fat area, fat mass-for-height and lean mass-for-height. Children with SCD-SS had significantly lower handgrip strength (12.7 ± 3.3 vs. 15.2 ± 5.1 kg, P < 0.008), peak power (882 ± 298 vs. 1167 ± 384 W, P < 0.001), and growth and body composition adjusted Z scores for handgrip strength (0.6 ± 1.3 standard deviations, P < 0.004) and peak power (male children = 1.0 ± 0.8 standard deviations, P < 0.0002; female children = 1.0 ± 1.7 standard deviations, P < 0.006). Maximal muscle strength and peak power are attenuated in children with SCD-SS compared with healthy control children beyond expectation for growth and body composition deficits suggesting that additional factors contribute to attenuation in anaerobic performance.

Authors+Show Affiliations

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA. doughertyk@email.chop.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21228717

Citation

Dougherty, Kelly A., et al. "Attenuated Maximal Muscle Strength and Peak Power in Children With Sickle Cell Disease." Journal of Pediatric Hematology/oncology, vol. 33, no. 2, 2011, pp. 93-7.
Dougherty KA, Schall JI, Rovner AJ, et al. Attenuated maximal muscle strength and peak power in children with sickle cell disease. J Pediatr Hematol Oncol. 2011;33(2):93-7.
Dougherty, K. A., Schall, J. I., Rovner, A. J., Stallings, V. A., & Zemel, B. S. (2011). Attenuated maximal muscle strength and peak power in children with sickle cell disease. Journal of Pediatric Hematology/oncology, 33(2), 93-7. https://doi.org/10.1097/MPH.0b013e318200ef49
Dougherty KA, et al. Attenuated Maximal Muscle Strength and Peak Power in Children With Sickle Cell Disease. J Pediatr Hematol Oncol. 2011;33(2):93-7. PubMed PMID: 21228717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attenuated maximal muscle strength and peak power in children with sickle cell disease. AU - Dougherty,Kelly A, AU - Schall,Joan I, AU - Rovner,Alisha J, AU - Stallings,Virginia A, AU - Zemel,Babette S, PY - 2011/1/14/entrez PY - 2011/1/14/pubmed PY - 2011/4/9/medline SP - 93 EP - 7 JF - Journal of pediatric hematology/oncology JO - J Pediatr Hematol Oncol VL - 33 IS - 2 N2 - Dominant hand maximal handgrip strength evaluated with a handgrip dynamometer and peak power evaluated with a force plate, adjusted for body size and composition, were compared in African-American children aged 5 to 13 years, with and without type SS sickle cell disease (SCD-SS). Children with SCD-SS (n = 35; age, 9.0 ± 2.0 y) compared with healthy control children (n = 103; age, 8.6 ± 1.8 y) did not differ by age, sex, or pubertal status, yet had significantly lower Z scores for height, weight, body mass index, upper arm muscle area, upper arm fat area, fat mass-for-height and lean mass-for-height. Children with SCD-SS had significantly lower handgrip strength (12.7 ± 3.3 vs. 15.2 ± 5.1 kg, P < 0.008), peak power (882 ± 298 vs. 1167 ± 384 W, P < 0.001), and growth and body composition adjusted Z scores for handgrip strength (0.6 ± 1.3 standard deviations, P < 0.004) and peak power (male children = 1.0 ± 0.8 standard deviations, P < 0.0002; female children = 1.0 ± 1.7 standard deviations, P < 0.006). Maximal muscle strength and peak power are attenuated in children with SCD-SS compared with healthy control children beyond expectation for growth and body composition deficits suggesting that additional factors contribute to attenuation in anaerobic performance. SN - 1536-3678 UR - https://www.unboundmedicine.com/medline/citation/21228717/Attenuated_maximal_muscle_strength_and_peak_power_in_children_with_sickle_cell_disease_ L2 - https://doi.org/10.1097/MPH.0b013e318200ef49 DB - PRIME DP - Unbound Medicine ER -