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Meta-based evidence for apolipoprotein E epsilon2/epsilon3/epsilon4 polymorphism in association with hypertension among Chinese.
J Hum Hypertens. 2011 Dec; 25(12):725-31.JH

Abstract

Mounting evidence suggests that hypertension is strongly linked to a variety of lipoprotein metabolism abnormalities. Apolipoprotein E gene (ApoE) is one such candidate with its common ɛ2/ɛ3/ɛ4 polymorphism ranking high in hypertension association. To derive more specific information, we pinpoint our research scope in Chinese to test whether this polymorphism is associated with hypertension via a meta-analysis. Random-effects model was performed irrespective of the between study heterogeneity. Data and study quality were assessed in duplicate. Publication bias was evaluated using the fail-safe number. Overall, 12 studies with 14 study groups totalling 1532 hypertensive patients and 2172 controls were identified. Carriers of ApoE ɛ2 allele had no significant increased risk for hypertension (pooled odds ratio (OR)=1.04; 95% confidence interval (CI): 0.80-1.35; P=0.78), compared with those carrying ɛ3 allele, whereas those with ɛ4 allele had a significant increased risk for hypertension (pooled OR=2.03; 95% CI: 1.61-2.55; P<0.00001). After excluding those with other small nationalities, we observed comparison of ApoE ɛ2 with ɛ3 allele yielded a pooled OR of 0.99 (95% CI: 0.82-1.19; P=0.89) among Han Chinese, and that of ɛ4 with ɛ3 yielded a pooled OR of 1.99 (95% CI: 1.48-2.67; P<0.00001). The fail-safe number at the level of 0.05 supported these significant associations. Taken together, our results expand previous findings and show that ApoE ɛ4 allele is associated with a twofold increased risk of developing hypertension in Chinese.

Authors+Show Affiliations

State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. niuwenquan@yahoo.cnNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21228824

Citation

Niu, W-Q, and Y Qi. "Meta-based Evidence for Apolipoprotein E Epsilon2/epsilon3/epsilon4 Polymorphism in Association With Hypertension Among Chinese." Journal of Human Hypertension, vol. 25, no. 12, 2011, pp. 725-31.
Niu WQ, Qi Y. Meta-based evidence for apolipoprotein E epsilon2/epsilon3/epsilon4 polymorphism in association with hypertension among Chinese. J Hum Hypertens. 2011;25(12):725-31.
Niu, W. Q., & Qi, Y. (2011). Meta-based evidence for apolipoprotein E epsilon2/epsilon3/epsilon4 polymorphism in association with hypertension among Chinese. Journal of Human Hypertension, 25(12), 725-31. https://doi.org/10.1038/jhh.2010.116
Niu WQ, Qi Y. Meta-based Evidence for Apolipoprotein E Epsilon2/epsilon3/epsilon4 Polymorphism in Association With Hypertension Among Chinese. J Hum Hypertens. 2011;25(12):725-31. PubMed PMID: 21228824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-based evidence for apolipoprotein E epsilon2/epsilon3/epsilon4 polymorphism in association with hypertension among Chinese. AU - Niu,W-Q, AU - Qi,Y, Y1 - 2011/01/13/ PY - 2011/1/14/entrez PY - 2011/1/14/pubmed PY - 2012/3/27/medline SP - 725 EP - 31 JF - Journal of human hypertension JO - J Hum Hypertens VL - 25 IS - 12 N2 - Mounting evidence suggests that hypertension is strongly linked to a variety of lipoprotein metabolism abnormalities. Apolipoprotein E gene (ApoE) is one such candidate with its common ɛ2/ɛ3/ɛ4 polymorphism ranking high in hypertension association. To derive more specific information, we pinpoint our research scope in Chinese to test whether this polymorphism is associated with hypertension via a meta-analysis. Random-effects model was performed irrespective of the between study heterogeneity. Data and study quality were assessed in duplicate. Publication bias was evaluated using the fail-safe number. Overall, 12 studies with 14 study groups totalling 1532 hypertensive patients and 2172 controls were identified. Carriers of ApoE ɛ2 allele had no significant increased risk for hypertension (pooled odds ratio (OR)=1.04; 95% confidence interval (CI): 0.80-1.35; P=0.78), compared with those carrying ɛ3 allele, whereas those with ɛ4 allele had a significant increased risk for hypertension (pooled OR=2.03; 95% CI: 1.61-2.55; P<0.00001). After excluding those with other small nationalities, we observed comparison of ApoE ɛ2 with ɛ3 allele yielded a pooled OR of 0.99 (95% CI: 0.82-1.19; P=0.89) among Han Chinese, and that of ɛ4 with ɛ3 yielded a pooled OR of 1.99 (95% CI: 1.48-2.67; P<0.00001). The fail-safe number at the level of 0.05 supported these significant associations. Taken together, our results expand previous findings and show that ApoE ɛ4 allele is associated with a twofold increased risk of developing hypertension in Chinese. SN - 1476-5527 UR - https://www.unboundmedicine.com/medline/citation/21228824/Meta_based_evidence_for_apolipoprotein_E_epsilon2/epsilon3/epsilon4_polymorphism_in_association_with_hypertension_among_Chinese_ L2 - https://doi.org/10.1038/jhh.2010.116 DB - PRIME DP - Unbound Medicine ER -