Tags

Type your tag names separated by a space and hit enter

Determination of total hypericins in St. John's wort and herbal medicinal products.
Acta Pol Pharm 2010 Nov-Dec; 67(6):586-92AP

Abstract

The work aimed to determine the levels of hypericins expressed as hypericin in the herbal substance of St. John's wort, in capsules and tablets containing the extract of St. John's wort, tablets containing powdered herb and in tincture and juice from fresh St. John's wort, by HPLC method with spectrophotometric detection. In addition, the amount of hypericins in the infusion prepared from St. John's wort was determined by HPLC and spectrophotometry methods. According to traditional indications aqueous infusions from St. John's wort containing mainly hydrophilic components are used in gastrointestinal diseases. On the other hand, ethanolic extracts containing hypericin and hyperforin affect the CNS and are indicated for the treatment of episodes of mild depressive disorders. The results obtained in the work indicate that the daily dose of hypericins taken by a patient as infusions is 0.328 mg on average for herbs in sachets and in bulk form. It can be compared to the daily dose of hypericins contained in tablets and capsules based on the alkoholic extract of St. John's wort and tablets containing powdered St. John's wort herb. For solid dosage forms, this dose ranges from 0.288 mg to 0.636 mg. The assays were performed using consistent analytical methods for all tested pharmaceutical products and consequently it was possible to compare doses taken by patients and their strength of action.

Authors+Show Affiliations

National Medicines Institute, Natural Medicinal Products Department, Pharmaceutical Chemistry Department, Chełmska 30/34, 00-725 Warszawa, Poland. manyzewska@il.waw.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21229872

Citation

Anyzewska, Małgorzata, et al. "Determination of Total Hypericins in St. John's Wort and Herbal Medicinal Products." Acta Poloniae Pharmaceutica, vol. 67, no. 6, 2010, pp. 586-92.
Anyzewska M, Kowalczuk A, Łozak A, et al. Determination of total hypericins in St. John's wort and herbal medicinal products. Acta Pol Pharm. 2010;67(6):586-92.
Anyzewska, M., Kowalczuk, A., Łozak, A., Jabłczyńska, R., & Fijałek, Z. (2010). Determination of total hypericins in St. John's wort and herbal medicinal products. Acta Poloniae Pharmaceutica, 67(6), pp. 586-92.
Anyzewska M, et al. Determination of Total Hypericins in St. John's Wort and Herbal Medicinal Products. Acta Pol Pharm. 2010;67(6):586-92. PubMed PMID: 21229872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of total hypericins in St. John's wort and herbal medicinal products. AU - Anyzewska,Małgorzata, AU - Kowalczuk,Anna, AU - Łozak,Anna, AU - Jabłczyńska,Renata, AU - Fijałek,Zbigniew, PY - 2011/1/15/entrez PY - 2011/1/15/pubmed PY - 2011/2/16/medline SP - 586 EP - 92 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 67 IS - 6 N2 - The work aimed to determine the levels of hypericins expressed as hypericin in the herbal substance of St. John's wort, in capsules and tablets containing the extract of St. John's wort, tablets containing powdered herb and in tincture and juice from fresh St. John's wort, by HPLC method with spectrophotometric detection. In addition, the amount of hypericins in the infusion prepared from St. John's wort was determined by HPLC and spectrophotometry methods. According to traditional indications aqueous infusions from St. John's wort containing mainly hydrophilic components are used in gastrointestinal diseases. On the other hand, ethanolic extracts containing hypericin and hyperforin affect the CNS and are indicated for the treatment of episodes of mild depressive disorders. The results obtained in the work indicate that the daily dose of hypericins taken by a patient as infusions is 0.328 mg on average for herbs in sachets and in bulk form. It can be compared to the daily dose of hypericins contained in tablets and capsules based on the alkoholic extract of St. John's wort and tablets containing powdered St. John's wort herb. For solid dosage forms, this dose ranges from 0.288 mg to 0.636 mg. The assays were performed using consistent analytical methods for all tested pharmaceutical products and consequently it was possible to compare doses taken by patients and their strength of action. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/21229872/Determination_of_total_hypericins_in_St__John's_wort_and_herbal_medicinal_products_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2010/6/586.pdf DB - PRIME DP - Unbound Medicine ER -