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Study protocol for a randomised trial of nicotine-free cigarettes as an adjunct to usual NRT-based cessation practice, in people who wish to stop smoking.
BMC Public Health. 2011 Jan 14; 11:37.BP

Abstract

BACKGROUND

Current smoking cessation treatments focus on addressing the pharmacological dependence of smokers on nicotine. However, new strategies are needed that address both nicotine dependence and the psychological dependence on cigarettes as the source of nicotine. Evidence from a number of small smoking cessation studies suggests that the use of cigarettes with reduced nicotine content, in combination with nicotine replacement therapy (NRT), may help reduce withdrawal symptoms and increase quit rates. This paper describes the protocol for a large randomised-controlled trial to test the effect of using nicotine-free cigarettes together with NRT on long-term quit rates.

METHODS/DESIGN

This single-blind, randomised trial aims to recruit 1,410 participants through the national telephone-based Quitline service in New Zealand. Participants in the treatment arm will be asked to stop smoking nicotine-containing cigarettes on their chosen Quit day and smoke ad libitum nicotine-free (Quest 3) cigarettes for six weeks. At the same time people in this group will be asked to start using NRT patches, gum and/or lozenges (as recommended by Quitline) for eight weeks. Participants in the control arm will be asked to stop smoking completely on their chosen Quit day and start using NRT patches, gum and/or lozenges (as recommended by Quitline) for eight weeks. Data collection will occur at baseline, three and six weeks, and three and six months after Quit day. The primary outcome is the proportion of participants who self-report seven-day point prevalence abstinence at six months since Quit date.

DISCUSSION

Smoking prevalence in New Zealand has changed little in recent years (particularly in Māori, the indigenous people of New Zealand) and additional options for smokers who want to quit are needed. Although a variety of methods are available to help, many are expensive, have side effects, and despite their use most quit attempts still fail. This trial will test the balance of benefits and risks of a new strategy for people to overcome nicotine dependence. Since smoking is the leading cause of lost healthy life years in New Zealand, if proven effective this strategy is likely to have substantial public health benefits.

Authors+Show Affiliations

Clinical Trials Research Unit, School of Population Health, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. n.walker@ctru.auckland.ac.nzNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21232155

Citation

Walker, Natalie K., et al. "Study Protocol for a Randomised Trial of Nicotine-free Cigarettes as an Adjunct to Usual NRT-based Cessation Practice, in People Who Wish to Stop Smoking." BMC Public Health, vol. 11, 2011, p. 37.
Walker NK, Howe C, Bullen C, et al. Study protocol for a randomised trial of nicotine-free cigarettes as an adjunct to usual NRT-based cessation practice, in people who wish to stop smoking. BMC Public Health. 2011;11:37.
Walker, N. K., Howe, C., Bullen, C., Grigg, M., Glover, M., McRobbie, H., Laugesen, M., Vander Hoorn, S., & Whittaker, R. (2011). Study protocol for a randomised trial of nicotine-free cigarettes as an adjunct to usual NRT-based cessation practice, in people who wish to stop smoking. BMC Public Health, 11, 37. https://doi.org/10.1186/1471-2458-11-37
Walker NK, et al. Study Protocol for a Randomised Trial of Nicotine-free Cigarettes as an Adjunct to Usual NRT-based Cessation Practice, in People Who Wish to Stop Smoking. BMC Public Health. 2011 Jan 14;11:37. PubMed PMID: 21232155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study protocol for a randomised trial of nicotine-free cigarettes as an adjunct to usual NRT-based cessation practice, in people who wish to stop smoking. AU - Walker,Natalie K, AU - Howe,Colin, AU - Bullen,Chris, AU - Grigg,Michele, AU - Glover,Marewa, AU - McRobbie,Hayden, AU - Laugesen,Murray, AU - Vander Hoorn,Stephen, AU - Whittaker,Robyn, Y1 - 2011/01/14/ PY - 2010/12/14/received PY - 2011/01/14/accepted PY - 2011/1/15/entrez PY - 2011/1/15/pubmed PY - 2011/3/2/medline SP - 37 EP - 37 JF - BMC public health JO - BMC Public Health VL - 11 N2 - BACKGROUND: Current smoking cessation treatments focus on addressing the pharmacological dependence of smokers on nicotine. However, new strategies are needed that address both nicotine dependence and the psychological dependence on cigarettes as the source of nicotine. Evidence from a number of small smoking cessation studies suggests that the use of cigarettes with reduced nicotine content, in combination with nicotine replacement therapy (NRT), may help reduce withdrawal symptoms and increase quit rates. This paper describes the protocol for a large randomised-controlled trial to test the effect of using nicotine-free cigarettes together with NRT on long-term quit rates. METHODS/DESIGN: This single-blind, randomised trial aims to recruit 1,410 participants through the national telephone-based Quitline service in New Zealand. Participants in the treatment arm will be asked to stop smoking nicotine-containing cigarettes on their chosen Quit day and smoke ad libitum nicotine-free (Quest 3) cigarettes for six weeks. At the same time people in this group will be asked to start using NRT patches, gum and/or lozenges (as recommended by Quitline) for eight weeks. Participants in the control arm will be asked to stop smoking completely on their chosen Quit day and start using NRT patches, gum and/or lozenges (as recommended by Quitline) for eight weeks. Data collection will occur at baseline, three and six weeks, and three and six months after Quit day. The primary outcome is the proportion of participants who self-report seven-day point prevalence abstinence at six months since Quit date. DISCUSSION: Smoking prevalence in New Zealand has changed little in recent years (particularly in Māori, the indigenous people of New Zealand) and additional options for smokers who want to quit are needed. Although a variety of methods are available to help, many are expensive, have side effects, and despite their use most quit attempts still fail. This trial will test the balance of benefits and risks of a new strategy for people to overcome nicotine dependence. Since smoking is the leading cause of lost healthy life years in New Zealand, if proven effective this strategy is likely to have substantial public health benefits. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/21232155/Study_protocol_for_a_randomised_trial_of_nicotine_free_cigarettes_as_an_adjunct_to_usual_NRT_based_cessation_practice_in_people_who_wish_to_stop_smoking_ L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-11-37 DB - PRIME DP - Unbound Medicine ER -