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Validation of the Spanish Version of the Addenbrooke's Cognitive Examination-Revised (ACE-R).
Neurologia. 2011 Jul-Aug; 26(6):351-6.N

Abstract

BACKGROUND

The Addenbrooke's Cognitive Examination Revised (ACE-R) is an improved version of the earlier brief screening test which has been validated in English with high sensitivity and specificity to detect cognitive dysfunction. The aim of this study was to validate the Spanish version of the ACE-R in an Argentine population.

METHODS

A group of patients with Alzheimer Disease (AD) and patients with behavioural variant Frontotemporal Dementia (bvFTD) paired by age, sex, and years of education with healthy controls were assessed using the ACE-R. Stage of dementia was measured with the Clinical Dementia Rating Scale (CDR). The English version of the ACE-R was first translated into Spanish and then back-translated into English by two blind independent experts.

RESULTS

Internal reliability was very good (Cronbach's alpha=0.89). Concurrent validity, determined by the correlation between total ACE-R and CDR was significant (P<.001) and inter-rater reliability was excellent (Cohen's kappa=0.98). Controls significantly outperformed AD and bvFTD patients on most subdomains of the ACE-R, with significant differences between the dementia groups. With a cut-off score of 85 points, sensitivity was 97.5% and specificity was 88.5%, with a likelihood ratio of 99.3 for the detection of dementia. The ACE-R showed higher sensitivity than the MMSE for the detection of dementia.

CONCLUSIONS

The Spanish version of the ACE-R is a brief yet reliable screening tool for the detection of early cognitive impairment and has shown to discriminate between bvFTD and AD.

Authors+Show Affiliations

Instituto de Neurología Cognitiva, Buenos Aires, Argentina. ttorralva@ineco.org.arNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng spa

PubMed ID

21232827

Citation

Torralva, T, et al. "Validation of the Spanish Version of the Addenbrooke's Cognitive Examination-Revised (ACE-R)." Neurologia (Barcelona, Spain), vol. 26, no. 6, 2011, pp. 351-6.
Torralva T, Roca M, Gleichgerrcht E, et al. Validation of the Spanish Version of the Addenbrooke's Cognitive Examination-Revised (ACE-R). Neurologia. 2011;26(6):351-6.
Torralva, T., Roca, M., Gleichgerrcht, E., Bonifacio, A., Raimondi, C., & Manes, F. (2011). Validation of the Spanish Version of the Addenbrooke's Cognitive Examination-Revised (ACE-R). Neurologia (Barcelona, Spain), 26(6), 351-6. https://doi.org/10.1016/j.nrl.2010.10.013
Torralva T, et al. Validation of the Spanish Version of the Addenbrooke's Cognitive Examination-Revised (ACE-R). Neurologia. 2011 Jul-Aug;26(6):351-6. PubMed PMID: 21232827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validation of the Spanish Version of the Addenbrooke's Cognitive Examination-Revised (ACE-R). AU - Torralva,T, AU - Roca,M, AU - Gleichgerrcht,E, AU - Bonifacio,A, AU - Raimondi,C, AU - Manes,F, Y1 - 2011/01/12/ PY - 2010/06/17/received PY - 2010/09/27/revised PY - 2010/10/12/accepted PY - 2011/1/15/entrez PY - 2011/1/15/pubmed PY - 2012/5/30/medline SP - 351 EP - 6 JF - Neurologia (Barcelona, Spain) JO - Neurologia VL - 26 IS - 6 N2 - BACKGROUND: The Addenbrooke's Cognitive Examination Revised (ACE-R) is an improved version of the earlier brief screening test which has been validated in English with high sensitivity and specificity to detect cognitive dysfunction. The aim of this study was to validate the Spanish version of the ACE-R in an Argentine population. METHODS: A group of patients with Alzheimer Disease (AD) and patients with behavioural variant Frontotemporal Dementia (bvFTD) paired by age, sex, and years of education with healthy controls were assessed using the ACE-R. Stage of dementia was measured with the Clinical Dementia Rating Scale (CDR). The English version of the ACE-R was first translated into Spanish and then back-translated into English by two blind independent experts. RESULTS: Internal reliability was very good (Cronbach's alpha=0.89). Concurrent validity, determined by the correlation between total ACE-R and CDR was significant (P<.001) and inter-rater reliability was excellent (Cohen's kappa=0.98). Controls significantly outperformed AD and bvFTD patients on most subdomains of the ACE-R, with significant differences between the dementia groups. With a cut-off score of 85 points, sensitivity was 97.5% and specificity was 88.5%, with a likelihood ratio of 99.3 for the detection of dementia. The ACE-R showed higher sensitivity than the MMSE for the detection of dementia. CONCLUSIONS: The Spanish version of the ACE-R is a brief yet reliable screening tool for the detection of early cognitive impairment and has shown to discriminate between bvFTD and AD. SN - 1578-1968 UR - https://www.unboundmedicine.com/medline/citation/21232827/Validation_of_the_Spanish_Version_of_the_Addenbrooke's_Cognitive_Examination_Revised__ACE_R__ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0213-4853(10)00325-7 DB - PRIME DP - Unbound Medicine ER -