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Fibroblast growth factor-2 alters the nature of extinction.
Learn Mem. 2011 Feb; 18(2):80-4.LM

Abstract

These experiments examined the effects of the NMDA-receptor (NMDAr) antagonist MK801 on reacquisition and re-extinction of a conditioned fear that had been previously extinguished before injection of fibroblast growth factor-2 (FGF2) or vehicle. Recent findings have shown that relearning and re-extinction, unlike initial learning and extinction, do not depend on NMDAr activation. Three experiments demonstrated that FGF2 prevents the switch from NMDAr-dependent to NMDAr-independent reacquisition and re-extinction, suggesting that FGF2 may lead to the partial erasure of the original fear memory. These findings add to a growing body of work suggesting that FGF2 may be a novel pharmacological enhancer of exposure therapy for humans with anxiety disorders.

Authors+Show Affiliations

School of Psychology, University of New South Wales, Sydney 2052, Australia. bgraham@psy.unsw.edu.auNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21233324

Citation

Graham, Bronwyn M., and Rick Richardson. "Fibroblast Growth Factor-2 Alters the Nature of Extinction." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 18, no. 2, 2011, pp. 80-4.
Graham BM, Richardson R. Fibroblast growth factor-2 alters the nature of extinction. Learn Mem. 2011;18(2):80-4.
Graham, B. M., & Richardson, R. (2011). Fibroblast growth factor-2 alters the nature of extinction. Learning & Memory (Cold Spring Harbor, N.Y.), 18(2), 80-4. https://doi.org/10.1101/lm.2006511
Graham BM, Richardson R. Fibroblast Growth Factor-2 Alters the Nature of Extinction. Learn Mem. 2011;18(2):80-4. PubMed PMID: 21233324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibroblast growth factor-2 alters the nature of extinction. AU - Graham,Bronwyn M, AU - Richardson,Rick, Y1 - 2011/01/13/ PY - 2011/1/15/entrez PY - 2011/1/15/pubmed PY - 2011/4/27/medline SP - 80 EP - 4 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 18 IS - 2 N2 - These experiments examined the effects of the NMDA-receptor (NMDAr) antagonist MK801 on reacquisition and re-extinction of a conditioned fear that had been previously extinguished before injection of fibroblast growth factor-2 (FGF2) or vehicle. Recent findings have shown that relearning and re-extinction, unlike initial learning and extinction, do not depend on NMDAr activation. Three experiments demonstrated that FGF2 prevents the switch from NMDAr-dependent to NMDAr-independent reacquisition and re-extinction, suggesting that FGF2 may lead to the partial erasure of the original fear memory. These findings add to a growing body of work suggesting that FGF2 may be a novel pharmacological enhancer of exposure therapy for humans with anxiety disorders. SN - 1549-5485 UR - https://www.unboundmedicine.com/medline/citation/21233324/Fibroblast_growth_factor_2_alters_the_nature_of_extinction_ DB - PRIME DP - Unbound Medicine ER -