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Sinisan, a traditional Chinese medicine, attenuates experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats.
J Hepatobiliary Pancreat Sci. 2011 Jul; 18(4):551-8.JH

Abstract

BACKGROUND/PURPOSE

Sinisan, a traditional Chinese medicine, is effective for the treatment of gastrointestinal disorders. In this study, we investigated the potential protective role of Sinisan against chronic pancreatitis (CP) in rats.

METHODS

CP was induced in rats by intrapancreatic injection of trinitrobenzene sulfonic acid (TNBS). Rats were randomly divided into a sham group, a TNBS-induced CP group and a Sinisan-treated group. Serum amylase and histological score were used to evaluate the severity of disease. The levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), interleukin-10 (IL-10) and α-smooth muscle actin (α-SMA) were also measured in the three groups. Mechanical allodynia was measured with von Frey filaments. In addition, the protein levels of nerve growth factor (NGF) were measured in pancreatic tissues.

RESULTS

Administration of Sinisan significantly decreased the severity of CP. In the Sinisan-treated group, serum amylase, TNF-α, IL-1β, COX-2 and α-SMA levels were lower and the level of IL-10 was upregulated compared with the TNBS-induced CP group. Furthermore, treatment with Sinisan significantly, though not completely, attenuated the allodynia. Simultaneously NGF expression was also significantly downregulated in the Sinisan-treated group compared with the TNBS-induced CP group.

CONCLUSIONS

Sinisan could be an effective treatment modality for CP via its anti-inflammatory, anti-fibrotic and analgesic properties. It may be a promising drug candidate for the treatment of patients with CP.

Authors+Show Affiliations

Department of Medical Image Center, Chinese PLA 302 Hospital, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21234610

Citation

Tang, Yu, et al. "Sinisan, a Traditional Chinese Medicine, Attenuates Experimental Chronic Pancreatitis Induced By Trinitrobenzene Sulfonic Acid in Rats." Journal of Hepato-biliary-pancreatic Sciences, vol. 18, no. 4, 2011, pp. 551-8.
Tang Y, Liao Y, Kawaguchi-Sakita N, et al. Sinisan, a traditional Chinese medicine, attenuates experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats. J Hepatobiliary Pancreat Sci. 2011;18(4):551-8.
Tang, Y., Liao, Y., Kawaguchi-Sakita, N., Raut, V., Fakhrejahani, E., Qian, N., & Toi, M. (2011). Sinisan, a traditional Chinese medicine, attenuates experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats. Journal of Hepato-biliary-pancreatic Sciences, 18(4), 551-8. https://doi.org/10.1007/s00534-010-0368-z
Tang Y, et al. Sinisan, a Traditional Chinese Medicine, Attenuates Experimental Chronic Pancreatitis Induced By Trinitrobenzene Sulfonic Acid in Rats. J Hepatobiliary Pancreat Sci. 2011;18(4):551-8. PubMed PMID: 21234610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sinisan, a traditional Chinese medicine, attenuates experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats. AU - Tang,Yu, AU - Liao,Yonghui, AU - Kawaguchi-Sakita,Nobuko, AU - Raut,Vikram, AU - Fakhrejahani,Elham, AU - Qian,Niansong, AU - Toi,Masakazu, PY - 2011/1/15/entrez PY - 2011/1/15/pubmed PY - 2011/12/13/medline SP - 551 EP - 8 JF - Journal of hepato-biliary-pancreatic sciences JO - J Hepatobiliary Pancreat Sci VL - 18 IS - 4 N2 - BACKGROUND/PURPOSE: Sinisan, a traditional Chinese medicine, is effective for the treatment of gastrointestinal disorders. In this study, we investigated the potential protective role of Sinisan against chronic pancreatitis (CP) in rats. METHODS: CP was induced in rats by intrapancreatic injection of trinitrobenzene sulfonic acid (TNBS). Rats were randomly divided into a sham group, a TNBS-induced CP group and a Sinisan-treated group. Serum amylase and histological score were used to evaluate the severity of disease. The levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), interleukin-10 (IL-10) and α-smooth muscle actin (α-SMA) were also measured in the three groups. Mechanical allodynia was measured with von Frey filaments. In addition, the protein levels of nerve growth factor (NGF) were measured in pancreatic tissues. RESULTS: Administration of Sinisan significantly decreased the severity of CP. In the Sinisan-treated group, serum amylase, TNF-α, IL-1β, COX-2 and α-SMA levels were lower and the level of IL-10 was upregulated compared with the TNBS-induced CP group. Furthermore, treatment with Sinisan significantly, though not completely, attenuated the allodynia. Simultaneously NGF expression was also significantly downregulated in the Sinisan-treated group compared with the TNBS-induced CP group. CONCLUSIONS: Sinisan could be an effective treatment modality for CP via its anti-inflammatory, anti-fibrotic and analgesic properties. It may be a promising drug candidate for the treatment of patients with CP. SN - 1868-6982 UR - https://www.unboundmedicine.com/medline/citation/21234610/Sinisan_a_traditional_Chinese_medicine_attenuates_experimental_chronic_pancreatitis_induced_by_trinitrobenzene_sulfonic_acid_in_rats_ L2 - https://doi.org/10.1007/s00534-010-0368-z DB - PRIME DP - Unbound Medicine ER -