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The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function.
Free Radic Res. 2011 Apr; 45(4):469-76.FR

Abstract

15-F₂(t)-isoprostane (15-F₂(t)-IsoP), an oxidation product of arachidonic acid (AA), affects vascular and platelet function; however, the bioactivity of other fatty acids oxidation products is unknown. This paper studied rat aortic vascular reactivity and human platelet aggregation in response to 14 oxidation products of AA, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and α-linolenic acid (ALA) compared with 15-F₂(t)-IsoP. It also compared the F₂(t)-IsoPs profile in human platelets. EPA-derived 15-F₃(t)-IsoP constricted rat aorta less than 15-F₂(t)-IsoP, but none of the other oxidation products affected vascular reactivity. Only 15-F₂(t)-IsoP (10⁻⁴ M) directly affected platelet aggregation. 15-F₃(t)-IsoP, ent-16-F₁-phytoprostane (from ALA) and isofurans A and B (from AA) inhibited reversible aggregation to U46619. Unlike plasma, the platelet profile of F₂-IsoP showed that 8-F(2t)-IsoP were higher than 15-F₂(t)-IsoP. Unlike 15-F₂(t)-IsoP, the test compounds derived from fatty acids oxidation did not affect vascular or platelet function. Elevated platelet 8-F₂(t)-IsoP could limit 15-F₂(t)-IsoP-induced aggregation under conditions of oxidant stress.

Authors+Show Affiliations

Cardiovascular Research Center, School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, Western Australia, Australia. barden@uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21235285

Citation

Barden, Anne, et al. "The Effects of Oxidation Products of Arachidonic Acid and N3 Fatty Acids On Vascular and Platelet Function." Free Radical Research, vol. 45, no. 4, 2011, pp. 469-76.
Barden A, Mas E, Henry P, et al. The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function. Free Radic Res. 2011;45(4):469-76.
Barden, A., Mas, E., Henry, P., Durand, T., Galano, J. M., Roberts, L. J., Croft, K. D., & Mori, T. A. (2011). The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function. Free Radical Research, 45(4), 469-76. https://doi.org/10.3109/10715762.2010.544730
Barden A, et al. The Effects of Oxidation Products of Arachidonic Acid and N3 Fatty Acids On Vascular and Platelet Function. Free Radic Res. 2011;45(4):469-76. PubMed PMID: 21235285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function. AU - Barden,Anne, AU - Mas,Emilie, AU - Henry,Peter, AU - Durand,Thierry, AU - Galano,Jean-Marie, AU - Roberts,L Jackson, AU - Croft,Kevin D, AU - Mori,Trevor A, Y1 - 2011/01/14/ PY - 2011/1/18/entrez PY - 2011/1/18/pubmed PY - 2011/7/1/medline SP - 469 EP - 76 JF - Free radical research JO - Free Radic Res VL - 45 IS - 4 N2 - 15-F₂(t)-isoprostane (15-F₂(t)-IsoP), an oxidation product of arachidonic acid (AA), affects vascular and platelet function; however, the bioactivity of other fatty acids oxidation products is unknown. This paper studied rat aortic vascular reactivity and human platelet aggregation in response to 14 oxidation products of AA, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and α-linolenic acid (ALA) compared with 15-F₂(t)-IsoP. It also compared the F₂(t)-IsoPs profile in human platelets. EPA-derived 15-F₃(t)-IsoP constricted rat aorta less than 15-F₂(t)-IsoP, but none of the other oxidation products affected vascular reactivity. Only 15-F₂(t)-IsoP (10⁻⁴ M) directly affected platelet aggregation. 15-F₃(t)-IsoP, ent-16-F₁-phytoprostane (from ALA) and isofurans A and B (from AA) inhibited reversible aggregation to U46619. Unlike plasma, the platelet profile of F₂-IsoP showed that 8-F(2t)-IsoP were higher than 15-F₂(t)-IsoP. Unlike 15-F₂(t)-IsoP, the test compounds derived from fatty acids oxidation did not affect vascular or platelet function. Elevated platelet 8-F₂(t)-IsoP could limit 15-F₂(t)-IsoP-induced aggregation under conditions of oxidant stress. SN - 1029-2470 UR - https://www.unboundmedicine.com/medline/citation/21235285/The_effects_of_oxidation_products_of_arachidonic_acid_and_n3_fatty_acids_on_vascular_and_platelet_function_ L2 - https://www.tandfonline.com/doi/full/10.3109/10715762.2010.544730 DB - PRIME DP - Unbound Medicine ER -