Tags

Type your tag names separated by a space and hit enter

Retroperitoneal pyogranulomatous and fibrosing inflammation secondary to fungal infections in two dogs.
J Am Vet Med Assoc. 2011 Jan 15; 238(2):213-9.JA

Abstract

CASE DESCRIPTIONS

A 4-year-old spayed female Golden Retriever (dog 1) was examined because of acute edema and erythema in the left hind limb and an inguinal mass, and a 5-year-old female Jack Russell Terrier (dog 2) was examined because of a recurring retro-peritoneal mass.

CLINICAL FINDINGS

Dog 1 had an edematous, hyperemic left hind limb with a fixed inguinal mass. Monocytic neutrophilic leukocytosis and hypoalbuminemia were detected. Diagnostic imaging revealed abnormal tissue surrounding the larger vessels and ureters and complete occlusion of the left limb veins. Surgery resulted in incomplete removal of the mass. Histologic examination revealed fibrosing pyogranulomatous inflammation. Results of a Histoplasma antigen test were positive, and reanalysis of the tissues revealed yeast cells indicative of Histoplasma capsulatum. Dog 2 had incomplete removal of a retroperitoneal mass. Histologic examination revealed fibrosing pyogranulomatous inflammation. The mass recurred 8 months later in dog 2; exploratory abdominal surgery at that time resulted in substantial hemorrhage from the adhered caudal aorta. Histologic examination of tissue sections from the second surgery revealed yeast cells consistent with Blastomyces dermatitidis.

TREATMENT AND OUTCOME

Both dogs had temporary improvement after surgery. Full clinical resolution required treatment for fungal disease. Dog 1 was treated with itraconazole, then fluconazole (total treatment time, 23 weeks). Dog 2 was treated with fluconazole for 36 weeks.

CLINICAL RELEVANCE

Retroperitoneal pyogranulomatous fibrosis caused by fungal infections has not been reported in veterinary medicine. There was substantial morbidity, but the prognosis can be good when this abnormality is recognized and antifungal medications are administered.

Authors+Show Affiliations

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA. drclemans@slvetspecialists.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21235375

Citation

Clemans, Jessica M., et al. "Retroperitoneal Pyogranulomatous and Fibrosing Inflammation Secondary to Fungal Infections in Two Dogs." Journal of the American Veterinary Medical Association, vol. 238, no. 2, 2011, pp. 213-9.
Clemans JM, Deitz KL, Riedesel EA, et al. Retroperitoneal pyogranulomatous and fibrosing inflammation secondary to fungal infections in two dogs. J Am Vet Med Assoc. 2011;238(2):213-9.
Clemans, J. M., Deitz, K. L., Riedesel, E. A., Yaeger, M. J., & Legendre, A. M. (2011). Retroperitoneal pyogranulomatous and fibrosing inflammation secondary to fungal infections in two dogs. Journal of the American Veterinary Medical Association, 238(2), 213-9. https://doi.org/10.2460/javma.238.2.213
Clemans JM, et al. Retroperitoneal Pyogranulomatous and Fibrosing Inflammation Secondary to Fungal Infections in Two Dogs. J Am Vet Med Assoc. 2011 Jan 15;238(2):213-9. PubMed PMID: 21235375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retroperitoneal pyogranulomatous and fibrosing inflammation secondary to fungal infections in two dogs. AU - Clemans,Jessica M, AU - Deitz,Krysta L, AU - Riedesel,Elizabeth A, AU - Yaeger,Michael J, AU - Legendre,Alfred M, PY - 2011/1/18/entrez PY - 2011/1/18/pubmed PY - 2011/3/9/medline SP - 213 EP - 9 JF - Journal of the American Veterinary Medical Association JO - J Am Vet Med Assoc VL - 238 IS - 2 N2 - CASE DESCRIPTIONS: A 4-year-old spayed female Golden Retriever (dog 1) was examined because of acute edema and erythema in the left hind limb and an inguinal mass, and a 5-year-old female Jack Russell Terrier (dog 2) was examined because of a recurring retro-peritoneal mass. CLINICAL FINDINGS: Dog 1 had an edematous, hyperemic left hind limb with a fixed inguinal mass. Monocytic neutrophilic leukocytosis and hypoalbuminemia were detected. Diagnostic imaging revealed abnormal tissue surrounding the larger vessels and ureters and complete occlusion of the left limb veins. Surgery resulted in incomplete removal of the mass. Histologic examination revealed fibrosing pyogranulomatous inflammation. Results of a Histoplasma antigen test were positive, and reanalysis of the tissues revealed yeast cells indicative of Histoplasma capsulatum. Dog 2 had incomplete removal of a retroperitoneal mass. Histologic examination revealed fibrosing pyogranulomatous inflammation. The mass recurred 8 months later in dog 2; exploratory abdominal surgery at that time resulted in substantial hemorrhage from the adhered caudal aorta. Histologic examination of tissue sections from the second surgery revealed yeast cells consistent with Blastomyces dermatitidis. TREATMENT AND OUTCOME: Both dogs had temporary improvement after surgery. Full clinical resolution required treatment for fungal disease. Dog 1 was treated with itraconazole, then fluconazole (total treatment time, 23 weeks). Dog 2 was treated with fluconazole for 36 weeks. CLINICAL RELEVANCE: Retroperitoneal pyogranulomatous fibrosis caused by fungal infections has not been reported in veterinary medicine. There was substantial morbidity, but the prognosis can be good when this abnormality is recognized and antifungal medications are administered. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/21235375/Retroperitoneal_pyogranulomatous_and_fibrosing_inflammation_secondary_to_fungal_infections_in_two_dogs_ L2 - https://avmajournals.avma.org/doi/10.2460/javma.238.2.213?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -