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Serum zinc, copper, and selenium levels in inflammatory bowel disease: effect of total enteral nutrition on trace element status.
Am J Gastroenterol 1990; 85(12):1584-9AJ

Abstract

Serum levels of zinc, copper, and selenium, and alkaline phosphatase activity were prospectively studied in 29 patients with inflammatory bowel disease. Fifteen patients had extensive active colitis (active colitis group). Seven patients had active, and seven cases inactive small bowel or ileocecal Crohn's disease (small bowel disease group). Ninety-three healthy subjects acted as controls. Serum trace element levels were considered in relation to vitamin A and E levels, nutritional parameters, the activity of the disease, and the recent intake of steroids. The effect of total enteral nutrition on serum trace elements was studied in seven cases. Serum zinc levels were lower and serum copper levels higher in the active colitis group than in controls (p = 0.0007, and p = 0.02, respectively). More than 50% of patients with active colonic or small bowel disease showed zinc levels below the 15th percentile of the control group. Serum zinc levels correlated with plasma vitamin A in acute colitis (r = 0.67; p = 0.006), and with both serum albumin concentration (r = 0.76; p = 0.002) and disease activity score (r = -0.67, p = 0.009) in patients with small bowel disease. The copper:zinc ratio was higher in the active colitis group than in controls (p = 0.002). In spite of the increase in serum albumin levels and the decrease in disease activity, serum zinc levels remained low after total enteral nutrition. The implications of the abnormal trace element status in patients with inflammatory bowel disease are discussed.

Authors+Show Affiliations

Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2123604

Citation

Fernández-Bañares, F, et al. "Serum Zinc, Copper, and Selenium Levels in Inflammatory Bowel Disease: Effect of Total Enteral Nutrition On Trace Element Status." The American Journal of Gastroenterology, vol. 85, no. 12, 1990, pp. 1584-9.
Fernández-Bañares F, Mingorance MD, Esteve M, et al. Serum zinc, copper, and selenium levels in inflammatory bowel disease: effect of total enteral nutrition on trace element status. Am J Gastroenterol. 1990;85(12):1584-9.
Fernández-Bañares, F., Mingorance, M. D., Esteve, M., Cabré, E., Lachica, M., Abad-Lacruz, A., ... Gassull, M. A. (1990). Serum zinc, copper, and selenium levels in inflammatory bowel disease: effect of total enteral nutrition on trace element status. The American Journal of Gastroenterology, 85(12), pp. 1584-9.
Fernández-Bañares F, et al. Serum Zinc, Copper, and Selenium Levels in Inflammatory Bowel Disease: Effect of Total Enteral Nutrition On Trace Element Status. Am J Gastroenterol. 1990;85(12):1584-9. PubMed PMID: 2123604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum zinc, copper, and selenium levels in inflammatory bowel disease: effect of total enteral nutrition on trace element status. AU - Fernández-Bañares,F, AU - Mingorance,M D, AU - Esteve,M, AU - Cabré,E, AU - Lachica,M, AU - Abad-Lacruz,A, AU - Gil,A, AU - Humbert,P, AU - Boix,J, AU - Gassull,M A, PY - 1990/12/1/pubmed PY - 1990/12/1/medline PY - 1990/12/1/entrez SP - 1584 EP - 9 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 85 IS - 12 N2 - Serum levels of zinc, copper, and selenium, and alkaline phosphatase activity were prospectively studied in 29 patients with inflammatory bowel disease. Fifteen patients had extensive active colitis (active colitis group). Seven patients had active, and seven cases inactive small bowel or ileocecal Crohn's disease (small bowel disease group). Ninety-three healthy subjects acted as controls. Serum trace element levels were considered in relation to vitamin A and E levels, nutritional parameters, the activity of the disease, and the recent intake of steroids. The effect of total enteral nutrition on serum trace elements was studied in seven cases. Serum zinc levels were lower and serum copper levels higher in the active colitis group than in controls (p = 0.0007, and p = 0.02, respectively). More than 50% of patients with active colonic or small bowel disease showed zinc levels below the 15th percentile of the control group. Serum zinc levels correlated with plasma vitamin A in acute colitis (r = 0.67; p = 0.006), and with both serum albumin concentration (r = 0.76; p = 0.002) and disease activity score (r = -0.67, p = 0.009) in patients with small bowel disease. The copper:zinc ratio was higher in the active colitis group than in controls (p = 0.002). In spite of the increase in serum albumin levels and the decrease in disease activity, serum zinc levels remained low after total enteral nutrition. The implications of the abnormal trace element status in patients with inflammatory bowel disease are discussed. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/2123604/Serum_zinc_copper_and_selenium_levels_in_inflammatory_bowel_disease:_effect_of_total_enteral_nutrition_on_trace_element_status_ DB - PRIME DP - Unbound Medicine ER -