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Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+: the involvement of PI3K/Akt pathway activation.
Toxicol Lett. 2011 Apr 10; 202(1):1-7.TL

Abstract

Oxidative stress plays an important role in the pathogenesis of Parkinson's disease (PD). 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG), which is an active component of the rhizome extract from polygonum multiflorum, shows potent antioxidant properties. In this paper, the neuroprotective effects of TSG on 1-methyl-4-phenylpyridinium (MPP+-induced apoptosis in PC12 cells were investigated. Pretreatment with TSG markedly attenuated MPP+-induced loss of cell viability and release of lactate dehydrogenase (LDH), and reduced MPP+-induced apoptotic cell death in a dose-dependent manner. The anti-apoptotic effects of TSG were probably mediated by the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway since TSG failed to rescue cells from MPP+ injury in the presence of the PI3K inhibitor, LY294002. These results indicate that TSG affords a significant neuroprotective effect against MPP+-induced damage and apoptosis in PC12 cells. The PI3K/Akt signaling pathway might be involved in the TSG-mediated anti-apoptotic effects.

Authors+Show Affiliations

Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi 712046, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21237255

Citation

Qin, Rong, et al. "Protection By Tetrahydroxystilbene Glucoside Against Neurotoxicity Induced By MPP+: the Involvement of PI3K/Akt Pathway Activation." Toxicology Letters, vol. 202, no. 1, 2011, pp. 1-7.
Qin R, Li X, Li G, et al. Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+: the involvement of PI3K/Akt pathway activation. Toxicol Lett. 2011;202(1):1-7.
Qin, R., Li, X., Li, G., Tao, L., Li, Y., Sun, J., Kang, X., & Chen, J. (2011). Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+: the involvement of PI3K/Akt pathway activation. Toxicology Letters, 202(1), 1-7. https://doi.org/10.1016/j.toxlet.2011.01.001
Qin R, et al. Protection By Tetrahydroxystilbene Glucoside Against Neurotoxicity Induced By MPP+: the Involvement of PI3K/Akt Pathway Activation. Toxicol Lett. 2011 Apr 10;202(1):1-7. PubMed PMID: 21237255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+: the involvement of PI3K/Akt pathway activation. AU - Qin,Rong, AU - Li,Xiaobing, AU - Li,Gang, AU - Tao,Lizhen, AU - Li,Yan, AU - Sun,Jing, AU - Kang,Xiaogang, AU - Chen,Jianzong, Y1 - 2011/01/13/ PY - 2010/02/28/received PY - 2010/12/24/revised PY - 2011/01/06/accepted PY - 2011/1/18/entrez PY - 2011/1/18/pubmed PY - 2011/4/19/medline SP - 1 EP - 7 JF - Toxicology letters JO - Toxicol Lett VL - 202 IS - 1 N2 - Oxidative stress plays an important role in the pathogenesis of Parkinson's disease (PD). 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG), which is an active component of the rhizome extract from polygonum multiflorum, shows potent antioxidant properties. In this paper, the neuroprotective effects of TSG on 1-methyl-4-phenylpyridinium (MPP+-induced apoptosis in PC12 cells were investigated. Pretreatment with TSG markedly attenuated MPP+-induced loss of cell viability and release of lactate dehydrogenase (LDH), and reduced MPP+-induced apoptotic cell death in a dose-dependent manner. The anti-apoptotic effects of TSG were probably mediated by the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway since TSG failed to rescue cells from MPP+ injury in the presence of the PI3K inhibitor, LY294002. These results indicate that TSG affords a significant neuroprotective effect against MPP+-induced damage and apoptosis in PC12 cells. The PI3K/Akt signaling pathway might be involved in the TSG-mediated anti-apoptotic effects. SN - 1879-3169 UR - https://www.unboundmedicine.com/medline/citation/21237255/Protection_by_tetrahydroxystilbene_glucoside_against_neurotoxicity_induced_by_MPP+:_the_involvement_of_PI3K/Akt_pathway_activation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-4274(11)00003-8 DB - PRIME DP - Unbound Medicine ER -