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The cortisol awakening response (CAR) across the female menstrual cycle.
Psychoneuroendocrinology. 2011 Jul; 36(6):905-12.P

Abstract

The cortisol awakening response (CAR) has been established as a useful marker of hypothalamus-pituitary-adrenal (HPA) axis activity and has become a standard tool for stress research in ambulatory settings. Although much knowledge has been accumulated on a variety of factors modulating the CAR, the impact of the female menstrual cycle, especially during ovulation, still remains unclear. To the best of our knowledge, this is the first study that measured the CAR during menses, the follicular phase, ovulation and the luteal phase in a repeated measurement design. For this purpose, a final sample of 29 naturally cycling, healthy, non-smoking, and medication-free women collected saliva samples directly after awakening as well as 30, 45, and 60 min later during each of the four different phases. To determine the timing of ovulation, an ambulatory chromatographic ovulation test kit was applied. A repeated measurements ANOVA resulted in a significant interaction effect sample × cycle phase (p=0.04), with the highest awakening response during ovulation. While awakening cortisol levels were comparable across the four cycle phases (p=n.s.), the net increase was significantly elevated during ovulation (p=0.05). Our data also confirmed earlier cross-sectional results reporting no differences in the CAR between the follicular and luteal phase. Finally, a concurrent assessment of mood applying the POMS (Profile of Mood States) yielded no differences across the four cycle phases (all p=n.s.). In sum, the present data points to the idea that the CAR is elevated during ovulation, an effect which is presumably mediated by elevated sex steroid levels during the ovulation period.

Authors+Show Affiliations

Jacobs Center on Lifelong Learning and Institutional Development, Jacobs University Bremen, Bremen, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21237574

Citation

Wolfram, Maren, et al. "The Cortisol Awakening Response (CAR) Across the Female Menstrual Cycle." Psychoneuroendocrinology, vol. 36, no. 6, 2011, pp. 905-12.
Wolfram M, Bellingrath S, Kudielka BM. The cortisol awakening response (CAR) across the female menstrual cycle. Psychoneuroendocrinology. 2011;36(6):905-12.
Wolfram, M., Bellingrath, S., & Kudielka, B. M. (2011). The cortisol awakening response (CAR) across the female menstrual cycle. Psychoneuroendocrinology, 36(6), 905-12. https://doi.org/10.1016/j.psyneuen.2010.12.006
Wolfram M, Bellingrath S, Kudielka BM. The Cortisol Awakening Response (CAR) Across the Female Menstrual Cycle. Psychoneuroendocrinology. 2011;36(6):905-12. PubMed PMID: 21237574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cortisol awakening response (CAR) across the female menstrual cycle. AU - Wolfram,Maren, AU - Bellingrath,Silja, AU - Kudielka,Brigitte M, Y1 - 2011/01/14/ PY - 2010/10/12/received PY - 2010/12/06/revised PY - 2010/12/07/accepted PY - 2011/1/18/entrez PY - 2011/1/18/pubmed PY - 2011/9/21/medline SP - 905 EP - 12 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 36 IS - 6 N2 - The cortisol awakening response (CAR) has been established as a useful marker of hypothalamus-pituitary-adrenal (HPA) axis activity and has become a standard tool for stress research in ambulatory settings. Although much knowledge has been accumulated on a variety of factors modulating the CAR, the impact of the female menstrual cycle, especially during ovulation, still remains unclear. To the best of our knowledge, this is the first study that measured the CAR during menses, the follicular phase, ovulation and the luteal phase in a repeated measurement design. For this purpose, a final sample of 29 naturally cycling, healthy, non-smoking, and medication-free women collected saliva samples directly after awakening as well as 30, 45, and 60 min later during each of the four different phases. To determine the timing of ovulation, an ambulatory chromatographic ovulation test kit was applied. A repeated measurements ANOVA resulted in a significant interaction effect sample × cycle phase (p=0.04), with the highest awakening response during ovulation. While awakening cortisol levels were comparable across the four cycle phases (p=n.s.), the net increase was significantly elevated during ovulation (p=0.05). Our data also confirmed earlier cross-sectional results reporting no differences in the CAR between the follicular and luteal phase. Finally, a concurrent assessment of mood applying the POMS (Profile of Mood States) yielded no differences across the four cycle phases (all p=n.s.). In sum, the present data points to the idea that the CAR is elevated during ovulation, an effect which is presumably mediated by elevated sex steroid levels during the ovulation period. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/21237574/The_cortisol_awakening_response__CAR__across_the_female_menstrual_cycle_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(10)00315-X DB - PRIME DP - Unbound Medicine ER -