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Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice.
Pharmacol Biochem Behav 2011; 98(2):261-7PB

Abstract

The aim of this study was to determine the effect of WIN 55,212-2 mesylate (WIN--a non-selective cannabinoid CB1 and CB2 receptor agonist) on the protective action of four classical antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, and valproate) in the mouse maximal electroshock seizure (MES) model. The results indicate that WIN (10 mg/kg, i.p.) significantly enhanced the anticonvulsant action of carbamazepine, phenytoin, phenobarbital and valproate in the MES test in mice. WIN (5 mg/kg) potentiated the anticonvulsant action of carbamazepine and valproate, but not that of phenytoin or phenobarbital in the MES test in mice. However, WIN administered alone and in combination with carbamazepine, phenytoin, phenobarbital and valproate significantly reduced muscular strength in mice in the grip-strength test. In the passive avoidance task, WIN in combination with phenobarbital, phenytoin and valproate significantly impaired long-term memory in mice. In the chimney test, only the combinations of WIN with phenobarbital and valproate significantly impaired motor coordination in mice. In conclusion, WIN enhanced the anticonvulsant action of carbamazepine, phenytoin, phenobarbital and valproate in the MES test. However, the utmost caution is advised when combining WIN with classical antiepileptic drugs due to impairment of motor coordination and long-term memory and/or reduction of skeletal muscular strength that might appear during combined treatment.

Authors+Show Affiliations

Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20-090 Lublin, Poland. jluszczki@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21238473

Citation

Luszczki, Jarogniew J., et al. "Synthetic Cannabinoid WIN 55,212-2 Mesylate Enhances the Protective Action of Four Classical Antiepileptic Drugs Against Maximal Electroshock-induced Seizures in Mice." Pharmacology, Biochemistry, and Behavior, vol. 98, no. 2, 2011, pp. 261-7.
Luszczki JJ, Misiuta-Krzesinska M, Florek M, et al. Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice. Pharmacol Biochem Behav. 2011;98(2):261-7.
Luszczki, J. J., Misiuta-Krzesinska, M., Florek, M., Tutka, P., & Czuczwar, S. J. (2011). Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice. Pharmacology, Biochemistry, and Behavior, 98(2), pp. 261-7. doi:10.1016/j.pbb.2011.01.002.
Luszczki JJ, et al. Synthetic Cannabinoid WIN 55,212-2 Mesylate Enhances the Protective Action of Four Classical Antiepileptic Drugs Against Maximal Electroshock-induced Seizures in Mice. Pharmacol Biochem Behav. 2011;98(2):261-7. PubMed PMID: 21238473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice. AU - Luszczki,Jarogniew J, AU - Misiuta-Krzesinska,Marta, AU - Florek,Magdalena, AU - Tutka,Piotr, AU - Czuczwar,Stanislaw J, Y1 - 2011/01/14/ PY - 2010/10/04/received PY - 2010/12/31/revised PY - 2011/01/08/accepted PY - 2011/1/18/entrez PY - 2011/1/18/pubmed PY - 2011/7/9/medline SP - 261 EP - 7 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 98 IS - 2 N2 - The aim of this study was to determine the effect of WIN 55,212-2 mesylate (WIN--a non-selective cannabinoid CB1 and CB2 receptor agonist) on the protective action of four classical antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, and valproate) in the mouse maximal electroshock seizure (MES) model. The results indicate that WIN (10 mg/kg, i.p.) significantly enhanced the anticonvulsant action of carbamazepine, phenytoin, phenobarbital and valproate in the MES test in mice. WIN (5 mg/kg) potentiated the anticonvulsant action of carbamazepine and valproate, but not that of phenytoin or phenobarbital in the MES test in mice. However, WIN administered alone and in combination with carbamazepine, phenytoin, phenobarbital and valproate significantly reduced muscular strength in mice in the grip-strength test. In the passive avoidance task, WIN in combination with phenobarbital, phenytoin and valproate significantly impaired long-term memory in mice. In the chimney test, only the combinations of WIN with phenobarbital and valproate significantly impaired motor coordination in mice. In conclusion, WIN enhanced the anticonvulsant action of carbamazepine, phenytoin, phenobarbital and valproate in the MES test. However, the utmost caution is advised when combining WIN with classical antiepileptic drugs due to impairment of motor coordination and long-term memory and/or reduction of skeletal muscular strength that might appear during combined treatment. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/21238473/abstract/Synthetic_cannabinoid_WIN_5 L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(11)00007-4 DB - PRIME DP - Unbound Medicine ER -