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Multiple roles of metalloproteinases in neurological disorders.
Prog Mol Biol Transl Sci. 2011; 99:241-63.PM

Abstract

Once thought to mainly act in brain to remodel the extracellular matrix, the family of metalloproteinases is important in many normal and pathological processes in the nervous system. Matrix metalloproteinases (MMPs) and A disintegrin and metalloproteinases (ADAMs) are the two major families of metalloproteinases in the brain. MMPs are comprised of several related enzymes that act on extracellular molecules. Normally, they are important in angiogenesis and neurogenesis in development. In neuroinflammatory illnesses, they disrupt the basal lamina and tight junction proteins to open the blood-brain barrier (BBB). ADAMs are important in neuroinflammation through activation of tumor necrosis factor-α (TNF-α) and their action as secretases that modulate the action of receptors on the cell surface. Four tissue inhibitors of metalloproteinases (TIMPs) are the main inhibitors of the MMPs and ADAMs. Recently, MMPs were found to affect DNA repair processes by an unexpected intranuclear action. MMPs and ADAMs have been implicated in the pathophysiology of neurodegenerative diseases such as Alzheimer's disease and vascular cognitive impairment. Growing literature on the functions of MMPs and ADAMs in the central nervous system is opening up new and exciting areas of research that may lead to novel approaches to treatment of neurological diseases.

Authors+Show Affiliations

Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21238938

Citation

Yang, Yi, et al. "Multiple Roles of Metalloproteinases in Neurological Disorders." Progress in Molecular Biology and Translational Science, vol. 99, 2011, pp. 241-63.
Yang Y, Hill JW, Rosenberg GA. Multiple roles of metalloproteinases in neurological disorders. Prog Mol Biol Transl Sci. 2011;99:241-63.
Yang, Y., Hill, J. W., & Rosenberg, G. A. (2011). Multiple roles of metalloproteinases in neurological disorders. Progress in Molecular Biology and Translational Science, 99, 241-63. https://doi.org/10.1016/B978-0-12-385504-6.00006-3
Yang Y, Hill JW, Rosenberg GA. Multiple Roles of Metalloproteinases in Neurological Disorders. Prog Mol Biol Transl Sci. 2011;99:241-63. PubMed PMID: 21238938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple roles of metalloproteinases in neurological disorders. AU - Yang,Yi, AU - Hill,Jeff W, AU - Rosenberg,Gary A, PY - 2011/1/18/entrez PY - 2011/1/18/pubmed PY - 2011/7/28/medline SP - 241 EP - 63 JF - Progress in molecular biology and translational science JO - Prog Mol Biol Transl Sci VL - 99 N2 - Once thought to mainly act in brain to remodel the extracellular matrix, the family of metalloproteinases is important in many normal and pathological processes in the nervous system. Matrix metalloproteinases (MMPs) and A disintegrin and metalloproteinases (ADAMs) are the two major families of metalloproteinases in the brain. MMPs are comprised of several related enzymes that act on extracellular molecules. Normally, they are important in angiogenesis and neurogenesis in development. In neuroinflammatory illnesses, they disrupt the basal lamina and tight junction proteins to open the blood-brain barrier (BBB). ADAMs are important in neuroinflammation through activation of tumor necrosis factor-α (TNF-α) and their action as secretases that modulate the action of receptors on the cell surface. Four tissue inhibitors of metalloproteinases (TIMPs) are the main inhibitors of the MMPs and ADAMs. Recently, MMPs were found to affect DNA repair processes by an unexpected intranuclear action. MMPs and ADAMs have been implicated in the pathophysiology of neurodegenerative diseases such as Alzheimer's disease and vascular cognitive impairment. Growing literature on the functions of MMPs and ADAMs in the central nervous system is opening up new and exciting areas of research that may lead to novel approaches to treatment of neurological diseases. SN - 1878-0814 UR - https://www.unboundmedicine.com/medline/citation/21238938/Multiple_roles_of_metalloproteinases_in_neurological_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/B978-0-12-385504-6.00006-3 DB - PRIME DP - Unbound Medicine ER -