Tags

Type your tag names separated by a space and hit enter

Chylomicron formation and glucagon-like peptide 1 receptor are involved in activation of the nutritional anti-inflammatory pathway.
J Nutr Biochem. 2011 Dec; 22(12):1105-11.JN

Abstract

Enteral administration of lipid-enriched nutrition effectively attenuates inflammation via a cholecystokinin (CCK)-mediated vagovagal anti-inflammatory reflex. Cholecystokinin release and subsequent activation of the vagus are dependent on chylomicron formation and associated with release of additional gut peptides. The current study investigates the intestinal processes underlying activation of the CCK-mediated vagal anti-inflammatory pathway by lipid-enriched nutrition. Rats and mice were subjected to hemorrhagic shock (HS) or endotoxemia, respectively. Prior to the experimental procedures, animals were fasted or fed lipid-enriched nutrition. Pluronic L-81 (L-81) was added to the feeding to investigate involvement of chylomicron formation in activation of mesenteric afferent fibers and the immune-modulating potential of lipid-enriched nutrition. Ob/Ob mice and selective receptor antagonists were used to study the role of leptin, glucagon-like peptide 1 and peptide YY in activation of the nutritional reflex. Electrophysiological analysis of mesenteric afferents in mice revealed that lipid-enriched nutrition-mediated neural activation was abrogated by L-81 (P<.05). L-81 blunted the beneficial effects of lipid-enriched nutrition on systemic inflammation and intestinal integrity in both species (all parameters, P<.01). Ob/Ob mice required a higher dose of nutrition compared with wild-type mice to attenuate plasma levels of TNF-α and ileum-lipid binding protein, a marker for enterocyte damage (both P<.01), suggesting a higher stimulation threshold in leptin-deficient mice. Administration of a glucagon-like peptide 1-receptor antagonist, but not leptin or peptide YY antagonists, suppressed the effects of lipid-enriched nutrition. These data indicate that chylomicron formation is essential and activation of the glucagon-like peptide 1-receptor is involved in activation of the nutritional anti-inflammatory pathway by lipid-enriched nutrition.

Authors+Show Affiliations

Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21239158

Citation

Lubbers, Tim, et al. "Chylomicron Formation and Glucagon-like Peptide 1 Receptor Are Involved in Activation of the Nutritional Anti-inflammatory Pathway." The Journal of Nutritional Biochemistry, vol. 22, no. 12, 2011, pp. 1105-11.
Lubbers T, de Haan JJ, Hadfoune M, et al. Chylomicron formation and glucagon-like peptide 1 receptor are involved in activation of the nutritional anti-inflammatory pathway. J Nutr Biochem. 2011;22(12):1105-11.
Lubbers, T., de Haan, J. J., Hadfoune, M., Zabeau, L., Tavernier, J., Zhang, Y., Grundy, D., Greve, J. W., & Buurman, W. A. (2011). Chylomicron formation and glucagon-like peptide 1 receptor are involved in activation of the nutritional anti-inflammatory pathway. The Journal of Nutritional Biochemistry, 22(12), 1105-11. https://doi.org/10.1016/j.jnutbio.2010.09.006
Lubbers T, et al. Chylomicron Formation and Glucagon-like Peptide 1 Receptor Are Involved in Activation of the Nutritional Anti-inflammatory Pathway. J Nutr Biochem. 2011;22(12):1105-11. PubMed PMID: 21239158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chylomicron formation and glucagon-like peptide 1 receptor are involved in activation of the nutritional anti-inflammatory pathway. AU - Lubbers,Tim, AU - de Haan,Jacco J, AU - Hadfoune,M'hamed, AU - Zabeau,Lennart, AU - Tavernier,Jan, AU - Zhang,Yiren, AU - Grundy,David, AU - Greve,Jan Willem M, AU - Buurman,Wim A, Y1 - 2011/01/15/ PY - 2010/06/09/received PY - 2010/09/12/revised PY - 2010/09/17/accepted PY - 2011/1/18/entrez PY - 2011/1/18/pubmed PY - 2012/7/13/medline SP - 1105 EP - 11 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 22 IS - 12 N2 - Enteral administration of lipid-enriched nutrition effectively attenuates inflammation via a cholecystokinin (CCK)-mediated vagovagal anti-inflammatory reflex. Cholecystokinin release and subsequent activation of the vagus are dependent on chylomicron formation and associated with release of additional gut peptides. The current study investigates the intestinal processes underlying activation of the CCK-mediated vagal anti-inflammatory pathway by lipid-enriched nutrition. Rats and mice were subjected to hemorrhagic shock (HS) or endotoxemia, respectively. Prior to the experimental procedures, animals were fasted or fed lipid-enriched nutrition. Pluronic L-81 (L-81) was added to the feeding to investigate involvement of chylomicron formation in activation of mesenteric afferent fibers and the immune-modulating potential of lipid-enriched nutrition. Ob/Ob mice and selective receptor antagonists were used to study the role of leptin, glucagon-like peptide 1 and peptide YY in activation of the nutritional reflex. Electrophysiological analysis of mesenteric afferents in mice revealed that lipid-enriched nutrition-mediated neural activation was abrogated by L-81 (P<.05). L-81 blunted the beneficial effects of lipid-enriched nutrition on systemic inflammation and intestinal integrity in both species (all parameters, P<.01). Ob/Ob mice required a higher dose of nutrition compared with wild-type mice to attenuate plasma levels of TNF-α and ileum-lipid binding protein, a marker for enterocyte damage (both P<.01), suggesting a higher stimulation threshold in leptin-deficient mice. Administration of a glucagon-like peptide 1-receptor antagonist, but not leptin or peptide YY antagonists, suppressed the effects of lipid-enriched nutrition. These data indicate that chylomicron formation is essential and activation of the glucagon-like peptide 1-receptor is involved in activation of the nutritional anti-inflammatory pathway by lipid-enriched nutrition. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/21239158/Chylomicron_formation_and_glucagon_like_peptide_1_receptor_are_involved_in_activation_of_the_nutritional_anti_inflammatory_pathway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(10)00233-0 DB - PRIME DP - Unbound Medicine ER -