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The growth hormone, prolactin and TSH response to TRH and L-dopa in patients with hyperprolactinaemia and a normal-sized sella turcica may denote a pituitary adenoma.
J Intern Med. 1990 Nov; 228(5):435-42.JI

Abstract

Forty-one patients with hyperprolactinaemia and suspected prolactinomas were studied. Growth hormone (GH) and thyrotropin (TSH) secretory patterns after thyrotropin releasing hormone (TRH) were affected in the majority of patients. The disturbances were observed regardless of tumour size as indicated by the radiological sella size. In patients with hyperprolactinaemia and normal-sized sella turcica, an abnormal GH and TSH response to TRH can be helpful in the diagnosis of a microadenoma. The hyperprolactinaemia per se and its effect on dopaminergic hypothalamic neurones may be the cause of the GH and TSH response. By contrast, many patients with macroprolactinomas showed insufficient GH secretory capacity.

Authors+Show Affiliations

Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2123920

Citation

Brismar, K, et al. "The Growth Hormone, Prolactin and TSH Response to TRH and L-dopa in Patients With Hyperprolactinaemia and a Normal-sized Sella Turcica May Denote a Pituitary Adenoma." Journal of Internal Medicine, vol. 228, no. 5, 1990, pp. 435-42.
Brismar K, Hulting AL, Werner S. The growth hormone, prolactin and TSH response to TRH and L-dopa in patients with hyperprolactinaemia and a normal-sized sella turcica may denote a pituitary adenoma. J Intern Med. 1990;228(5):435-42.
Brismar, K., Hulting, A. L., & Werner, S. (1990). The growth hormone, prolactin and TSH response to TRH and L-dopa in patients with hyperprolactinaemia and a normal-sized sella turcica may denote a pituitary adenoma. Journal of Internal Medicine, 228(5), 435-42.
Brismar K, Hulting AL, Werner S. The Growth Hormone, Prolactin and TSH Response to TRH and L-dopa in Patients With Hyperprolactinaemia and a Normal-sized Sella Turcica May Denote a Pituitary Adenoma. J Intern Med. 1990;228(5):435-42. PubMed PMID: 2123920.
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TY - JOUR T1 - The growth hormone, prolactin and TSH response to TRH and L-dopa in patients with hyperprolactinaemia and a normal-sized sella turcica may denote a pituitary adenoma. AU - Brismar,K, AU - Hulting,A L, AU - Werner,S, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 435 EP - 42 JF - Journal of internal medicine JO - J Intern Med VL - 228 IS - 5 N2 - Forty-one patients with hyperprolactinaemia and suspected prolactinomas were studied. Growth hormone (GH) and thyrotropin (TSH) secretory patterns after thyrotropin releasing hormone (TRH) were affected in the majority of patients. The disturbances were observed regardless of tumour size as indicated by the radiological sella size. In patients with hyperprolactinaemia and normal-sized sella turcica, an abnormal GH and TSH response to TRH can be helpful in the diagnosis of a microadenoma. The hyperprolactinaemia per se and its effect on dopaminergic hypothalamic neurones may be the cause of the GH and TSH response. By contrast, many patients with macroprolactinomas showed insufficient GH secretory capacity. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/2123920/The_growth_hormone_prolactin_and_TSH_response_to_TRH_and_L_dopa_in_patients_with_hyperprolactinaemia_and_a_normal_sized_sella_turcica_may_denote_a_pituitary_adenoma_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-6820&date=1990&volume=228&issue=5&spage=435 DB - PRIME DP - Unbound Medicine ER -