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Red meat, dietary nitrosamines, and heme iron and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Abstract

BACKGROUND

Previous epidemiologic studies found inconsistent results for the association between red meat intake, nitrosamines [NDMA: N-nitrosodimethylamine, and ENOC (endogenous nitroso compounds)], and the risk of bladder cancer. We investigated the association between red meat consumption, dietary nitrosamines, and heme iron and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC).

METHODS

Data on food consumption and complete follow-up for cancer occurrence were available for a total of 481,419 participants, recruited in 10 European countries. Estimates of HRs were obtained by proportional hazard models, stratified by age at recruitment, gender, and study center and adjusted for total energy intake, smoking status, lifetime intensity of smoking, duration of smoking, educational level, and BMI.

RESULTS

After a mean follow-up of 8.7 years, 1,001 participants were diagnosed with bladder cancer. We found no overall association between intake of red meat (log2 HR: 1.06; 95% CI: 0.99-1.13), nitrosamines (log2 HR: 1.09; 95% CI: 0.92-1.30 and HR: 0.98; 95% CI: 0.92-1.05 for ENOC and NDMA, respectively) or heme iron (log2 HR: 1.05; 95 CI: 0.99-1.12) and bladder cancer risk. The associations did not vary by sex, high- versus low-risk bladder cancers, smoking status, or occupation (high vs. low risk).

CONCLUSIONS

Our findings do not support an effect of red meat intake, nitrosamines (endogenous or exogenous), or heme iron intake on bladder cancer risk.

Authors+Show Affiliations

Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, AV gran via 199 (08907), L'Hospitalet de Llobregat, Barcelona, Spain. paujak@iconcologia.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21239687

Citation

Jakszyn, Paula, et al. "Red Meat, Dietary Nitrosamines, and Heme Iron and Risk of Bladder Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 20, no. 3, 2011, pp. 555-9.
Jakszyn P, González CA, Luján-Barroso L, et al. Red meat, dietary nitrosamines, and heme iron and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiol Biomarkers Prev. 2011;20(3):555-9.
Jakszyn, P., González, C. A., Luján-Barroso, L., Ros, M. M., Bueno-de-Mesquita, H. B., Roswall, N., ... Riboli, E. (2011). Red meat, dietary nitrosamines, and heme iron and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 20(3), pp. 555-9. doi:10.1158/1055-9965.EPI-10-0971.
Jakszyn P, et al. Red Meat, Dietary Nitrosamines, and Heme Iron and Risk of Bladder Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Cancer Epidemiol Biomarkers Prev. 2011;20(3):555-9. PubMed PMID: 21239687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red meat, dietary nitrosamines, and heme iron and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). AU - Jakszyn,Paula, AU - González,Carlos A, AU - Luján-Barroso,Leila, AU - Ros,Martine M, AU - Bueno-de-Mesquita,H Bas, AU - Roswall,Nina, AU - Tjønneland,Anne M, AU - Büchner,Frederike L, AU - Egevad,Lars, AU - Overvad,Kim, AU - Raaschou-Nielsen,Ole, AU - Clavel-Chapelon,Françoise, AU - Boutron-Ruault,Marie-Christine, AU - Touillaud,Marina S, AU - Chang-Claude,Jenny, AU - Allen,Naomi E, AU - Kiemeney,Lambertus A, AU - Key,Timothy J, AU - Kaaks,Rudolf, AU - Boeing,Heiner, AU - Weikert,Steffen, AU - Trichopoulou,Antonia, AU - Oikonomou,Eleni, AU - Zylis,Dimosthenis, AU - Palli,Domenico, AU - Berrino,Franco, AU - Vineis,Paolo, AU - Tumino,Rosario, AU - Mattiello,Amalia, AU - Peeters,Petra H M, AU - Parr,Christine L, AU - Gram,Inger T, AU - Skeie,Guri, AU - Sánchez,Maria-Jose, AU - Larrañaga,Nerea, AU - Ardanaz,Eva, AU - Navarro,Carmen, AU - Rodríguez,Laudina, AU - Ulmert,David, AU - Ehrnström,Roy, AU - Hallmans,Göran, AU - Ljungberg,Borje, AU - Roddam,Andrew Wilfred, AU - Bingham,Sheila A, AU - Khaw,Kay-Tee, AU - Slimani,Nadia, AU - Boffetta,Paolo A, AU - Jenab,Mazda, AU - Mouw,Traci, AU - Michaud,Dominique S, AU - Riboli,Elio, Y1 - 2011/01/14/ PY - 2011/1/18/entrez PY - 2011/1/18/pubmed PY - 2011/7/20/medline SP - 555 EP - 9 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 20 IS - 3 N2 - BACKGROUND: Previous epidemiologic studies found inconsistent results for the association between red meat intake, nitrosamines [NDMA: N-nitrosodimethylamine, and ENOC (endogenous nitroso compounds)], and the risk of bladder cancer. We investigated the association between red meat consumption, dietary nitrosamines, and heme iron and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: Data on food consumption and complete follow-up for cancer occurrence were available for a total of 481,419 participants, recruited in 10 European countries. Estimates of HRs were obtained by proportional hazard models, stratified by age at recruitment, gender, and study center and adjusted for total energy intake, smoking status, lifetime intensity of smoking, duration of smoking, educational level, and BMI. RESULTS: After a mean follow-up of 8.7 years, 1,001 participants were diagnosed with bladder cancer. We found no overall association between intake of red meat (log2 HR: 1.06; 95% CI: 0.99-1.13), nitrosamines (log2 HR: 1.09; 95% CI: 0.92-1.30 and HR: 0.98; 95% CI: 0.92-1.05 for ENOC and NDMA, respectively) or heme iron (log2 HR: 1.05; 95 CI: 0.99-1.12) and bladder cancer risk. The associations did not vary by sex, high- versus low-risk bladder cancers, smoking status, or occupation (high vs. low risk). CONCLUSIONS: Our findings do not support an effect of red meat intake, nitrosamines (endogenous or exogenous), or heme iron intake on bladder cancer risk. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/21239687/Red_meat_dietary_nitrosamines_and_heme_iron_and_risk_of_bladder_cancer_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC__ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=21239687 DB - PRIME DP - Unbound Medicine ER -